LT3369724T - Iopamidolio gamybos būdas - Google Patents
Iopamidolio gamybos būdasInfo
- Publication number
- LT3369724T LT3369724T LTEP18162482.6T LT18162482T LT3369724T LT 3369724 T LT3369724 T LT 3369724T LT 18162482 T LT18162482 T LT 18162482T LT 3369724 T LT3369724 T LT 3369724T
- Authority
- LT
- Lithuania
- Prior art keywords
- iopamidol
- manufacture
- Prior art date
Links
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title 1
- 229960004647 iopamidol Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13191551 | 2013-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3369724T true LT3369724T (lt) | 2021-02-25 |
Family
ID=49517391
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP14796024.9T LT3066071T (lt) | 2013-11-05 | 2014-11-04 | Jopamidolio gamybos būdas |
| LTEP18162482.6T LT3369724T (lt) | 2013-11-05 | 2014-11-04 | Iopamidolio gamybos būdas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP14796024.9T LT3066071T (lt) | 2013-11-05 | 2014-11-04 | Jopamidolio gamybos būdas |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US9950991B2 (lt) |
| EP (2) | EP3369724B1 (lt) |
| JP (1) | JP6454351B2 (lt) |
| KR (2) | KR102265049B1 (lt) |
| CN (1) | CN105705483B (lt) |
| AU (1) | AU2014345727B2 (lt) |
| BR (1) | BR112016010223B1 (lt) |
| CA (2) | CA2927706C (lt) |
| DK (2) | DK3369724T3 (lt) |
| ES (2) | ES2674279T3 (lt) |
| HR (2) | HRP20181122T1 (lt) |
| HU (2) | HUE053751T2 (lt) |
| IL (1) | IL245457B (lt) |
| LT (2) | LT3066071T (lt) |
| MX (2) | MX375753B (lt) |
| PL (2) | PL3369724T3 (lt) |
| PT (2) | PT3369724T (lt) |
| RU (1) | RU2657238C2 (lt) |
| SI (2) | SI3369724T1 (lt) |
| TR (1) | TR201808527T4 (lt) |
| WO (1) | WO2015067601A1 (lt) |
| ZA (1) | ZA201602970B (lt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106366016B (zh) * | 2015-07-22 | 2019-03-05 | 连云港润众制药有限公司 | 一种碘普罗胺的制备方法及其中间体 |
| CN106366015B (zh) * | 2015-07-22 | 2019-01-25 | 正大天晴药业集团股份有限公司 | 一种碘普罗胺的制备方法及其中间体 |
| MX2020004425A (es) | 2017-11-01 | 2020-08-06 | Melinta Therapeutics Inc | Síntesis de derivados de éster boronato y usos de estos. |
| CN109293526A (zh) * | 2018-10-23 | 2019-02-01 | 湖北天舒药业有限公司 | 一种碘帕醇的合成及其合成中间体的制备 |
| BR112022016078A2 (pt) * | 2020-02-14 | 2022-10-04 | Solvay | Composição, processo de flotação de espuma para recuperar minerais de valor a partir de minério e outras matérias-primas, e, uso de uma composição |
| GB202009917D0 (en) * | 2020-06-29 | 2020-08-12 | Ge Healthcare As | Process for the preparation of iopamidol |
| CN116745260A (zh) * | 2021-03-22 | 2023-09-12 | 伯拉考成像股份公司 | 丝氨醇的工业合成 |
| WO2023117667A1 (en) | 2021-12-20 | 2023-06-29 | Bracco Imaging Spa | Process for the preparation of 2,4,6-triiodoisophthalic bisamides |
| CN115010617B (zh) * | 2022-07-11 | 2024-06-11 | 安徽普利药业有限公司 | 一种碘帕醇的制备方法 |
| EP4534526A1 (en) | 2023-10-04 | 2025-04-09 | Bracco Imaging SPA | Optimized process for the preparation of iopamidol |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (lt) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| IT1256162B (it) | 1992-10-27 | 1995-11-29 | Zambon Spa | Processo per la preparazione di un intermedio della sintesi organica |
| IT1274027B (it) | 1994-03-03 | 1997-07-14 | Zambon Spa | Processo per la preparazione e purificazione di mezzi di contrasto iodurati |
| IT1274676B (it) * | 1994-04-14 | 1997-07-24 | Zambon Spa | Processo per la preparazione di 5-ammino-2,2-dialchil-1,3-diossani |
| IT1282674B1 (it) | 1996-02-23 | 1998-03-31 | Bracco Spa | Processo per la purificazione di agenti contrastografici opacizzanti |
| HU216537B (hu) | 1995-05-23 | 1999-07-28 | Fructamine S.P.A. | Eljárás dikarbonsav-diklorid előállítására, izolálására és tisztítására, és az előállított S-(-)-izomer |
| US5763650A (en) | 1995-05-23 | 1998-06-09 | Fructamine S.P.A. | Process for the preparation of a halosubstituted aromatic acid |
| DK0773924T3 (da) | 1995-05-23 | 1999-09-20 | Fructamine Spa | Fremgangsmåde til fremstilling af et dicarboxylsyredichlorid |
| IT1288114B1 (it) | 1996-06-13 | 1998-09-10 | Fructamine Spa | Processo per la purificazione di un intermedio |
| IT1286522B1 (it) | 1996-12-04 | 1998-07-15 | Dibra Spa | Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico |
| IT1289520B1 (it) * | 1996-12-24 | 1998-10-15 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
| GB2331098A (en) | 1997-11-07 | 1999-05-12 | Nycomed Imaging As | An N-Alkylation process |
| IT1299202B1 (it) | 1998-05-08 | 2000-02-29 | Dibra Spa | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
| GB9825095D0 (en) | 1998-11-16 | 1999-01-13 | Nycomed Imaging As | Chemical process |
| US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
| IT1319671B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino) |
| IT1319670B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'- |
| AU2003269474A1 (en) | 2003-08-26 | 2005-03-10 | Biocon Limited | Process for purification of boronic acid and its derivatives |
| ES2380549T3 (es) | 2005-10-21 | 2012-05-16 | Video Taped Transcripts Pty. Ltd. | Un método para producir una guarnición retrorreflectante perforada |
| EP2093206A1 (en) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
| PT2365963T (pt) | 2008-11-18 | 2017-08-22 | Bracco Imaging Spa | Processo para a preparação de agente de contraste iodado |
| EP2243767A1 (en) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Process for the iodination of aromatic compounds |
| PT2451994E (pt) | 2009-07-07 | 2014-01-07 | Bracco Imaging Spa | Processo para a preparação de um agente de iodação |
| EP2394984A1 (en) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Process for the iodination of phenolic derivatives |
-
2014
- 2014-11-04 PT PT181624826T patent/PT3369724T/pt unknown
- 2014-11-04 US US15/033,737 patent/US9950991B2/en active Active
- 2014-11-04 HU HUE18162482A patent/HUE053751T2/hu unknown
- 2014-11-04 PT PT147960249T patent/PT3066071T/pt unknown
- 2014-11-04 CA CA2927706A patent/CA2927706C/en active Active
- 2014-11-04 ES ES14796024.9T patent/ES2674279T3/es active Active
- 2014-11-04 PL PL18162482T patent/PL3369724T3/pl unknown
- 2014-11-04 MX MX2016005829A patent/MX375753B/es active IP Right Grant
- 2014-11-04 LT LTEP14796024.9T patent/LT3066071T/lt unknown
- 2014-11-04 HU HUE14796024A patent/HUE039440T2/hu unknown
- 2014-11-04 DK DK18162482.6T patent/DK3369724T3/da active
- 2014-11-04 MX MX2020010367A patent/MX380203B/es unknown
- 2014-11-04 EP EP18162482.6A patent/EP3369724B1/en active Active
- 2014-11-04 JP JP2016551022A patent/JP6454351B2/ja active Active
- 2014-11-04 SI SI201431776T patent/SI3369724T1/sl unknown
- 2014-11-04 SI SI201430793T patent/SI3066071T1/en unknown
- 2014-11-04 LT LTEP18162482.6T patent/LT3369724T/lt unknown
- 2014-11-04 BR BR112016010223-1A patent/BR112016010223B1/pt active IP Right Grant
- 2014-11-04 KR KR1020167014721A patent/KR102265049B1/ko active Active
- 2014-11-04 DK DK14796024.9T patent/DK3066071T3/en active
- 2014-11-04 CA CA3001399A patent/CA3001399C/en active Active
- 2014-11-04 TR TR2018/08527T patent/TR201808527T4/tr unknown
- 2014-11-04 WO PCT/EP2014/073692 patent/WO2015067601A1/en not_active Ceased
- 2014-11-04 HR HRP20181122TT patent/HRP20181122T1/hr unknown
- 2014-11-04 PL PL14796024T patent/PL3066071T3/pl unknown
- 2014-11-04 AU AU2014345727A patent/AU2014345727B2/en active Active
- 2014-11-04 ES ES18162482T patent/ES2862349T3/es active Active
- 2014-11-04 EP EP14796024.9A patent/EP3066071B1/en active Active
- 2014-11-04 KR KR1020217017633A patent/KR102382351B1/ko active Active
- 2014-11-04 RU RU2016122022A patent/RU2657238C2/ru active
- 2014-11-04 CN CN201480060539.4A patent/CN105705483B/zh active Active
-
2016
- 2016-05-03 IL IL245457A patent/IL245457B/en active IP Right Grant
- 2016-05-04 ZA ZA2016/02970A patent/ZA201602970B/en unknown
-
2018
- 2018-03-06 US US15/912,772 patent/US10377700B2/en active Active
- 2018-08-02 US US16/052,695 patent/US20190077745A1/en not_active Abandoned
-
2021
- 2021-02-25 HR HRP20210324TT patent/HRP20210324T1/hr unknown
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