LT3319970T - Pirido-oksazinono dariniai kaip tnap inhibitoriai - Google Patents
Pirido-oksazinono dariniai kaip tnap inhibitoriaiInfo
- Publication number
- LT3319970T LT3319970T LT16775006T LT16775006T LT3319970T LT 3319970 T LT3319970 T LT 3319970T LT 16775006 T LT16775006 T LT 16775006T LT 16775006 T LT16775006 T LT 16775006T LT 3319970 T LT3319970 T LT 3319970T
- Authority
- LT
- Lithuania
- Prior art keywords
- pyrido
- tnap inhibitors
- oxazinone derivatives
- oxazinone
- derivatives
- Prior art date
Links
- JLTPSDHKZGWXTD-UHFFFAOYSA-N 2-[6-(dicyanomethylidene)naphthalen-2-ylidene]propanedinitrile Chemical compound N#CC(C#N)=C1C=CC2=CC(=C(C#N)C#N)C=CC2=C1 JLTPSDHKZGWXTD-UHFFFAOYSA-N 0.000 title 1
- FHZIDNIJVVSXDL-UHFFFAOYSA-N 4h-pyrido[2,3-e]oxazin-3-one Chemical class C1=CC=C2ONC(=O)CC2=N1 FHZIDNIJVVSXDL-UHFFFAOYSA-N 0.000 title 1
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 title 1
- 101710161969 Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562190145P | 2015-07-08 | 2015-07-08 | |
| PCT/US2016/041345 WO2017007943A1 (en) | 2015-07-08 | 2016-07-07 | Pyrido-oxazinone derivatives as tnap inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3319970T true LT3319970T (lt) | 2019-11-11 |
Family
ID=57045381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT16775006T LT3319970T (lt) | 2015-07-08 | 2016-07-07 | Pirido-oksazinono dariniai kaip tnap inhibitoriai |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US9920068B2 (lt) |
| EP (1) | EP3319970B1 (lt) |
| JP (1) | JP6666928B2 (lt) |
| KR (1) | KR102590067B1 (lt) |
| CN (1) | CN107207527B (lt) |
| AU (1) | AU2016291163B2 (lt) |
| CA (1) | CA2962795C (lt) |
| CO (1) | CO2017003830A2 (lt) |
| CY (1) | CY1122477T1 (lt) |
| DK (1) | DK3319970T3 (lt) |
| ES (1) | ES2754480T3 (lt) |
| HR (1) | HRP20192121T1 (lt) |
| HU (1) | HUE046994T2 (lt) |
| IL (1) | IL251005B (lt) |
| LT (1) | LT3319970T (lt) |
| MX (1) | MX2017003822A (lt) |
| MY (1) | MY185558A (lt) |
| PH (1) | PH12018500066A1 (lt) |
| PL (1) | PL3319970T3 (lt) |
| PT (1) | PT3319970T (lt) |
| RS (1) | RS59594B1 (lt) |
| RU (1) | RU2715704C2 (lt) |
| SG (1) | SG11201701378WA (lt) |
| SI (1) | SI3319970T1 (lt) |
| SM (1) | SMT201900666T1 (lt) |
| TW (1) | TWI702220B (lt) |
| WO (1) | WO2017007943A1 (lt) |
| ZA (1) | ZA201701783B (lt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7005629B2 (ja) * | 2016-12-23 | 2022-01-21 | 第一三共株式会社 | Ｔｎａｐ阻害活性を有するスルホンアミド化合物 |
| WO2018119449A1 (en) * | 2016-12-23 | 2018-06-28 | Daiichi Sankyo Company, Limited | Oxazepine derivatives having tnap inhibitory activity |
| CN112912139B (zh) * | 2018-10-23 | 2024-07-09 | 第一三共株式会社 | 联芳基衍生物 |
| CN114085911B (zh) * | 2022-01-19 | 2022-05-17 | 珠海圣美生物诊断技术有限公司 | 一种检测肿瘤细胞或肿瘤细胞碎片的方法 |
| TW202513066A (zh) * | 2023-09-25 | 2025-04-01 | 日商第一三共股份有限公司 | 製造n-吡啶基磺醯胺化合物之方法、吡啶化合物、及n-吡啶基磺醯胺化合物之結晶 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810795A (en) | 1982-09-30 | 1989-03-07 | A. H. Robins Company, Incorporated | Certain 2,5 and 2,5,6-di- and tri-substituted nicotinic acid intermediates |
| EP1145714A4 (en) | 1998-11-27 | 2004-12-15 | Takeda Chemical Industries Ltd | DRUGS |
| PE20011061A1 (es) * | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
| JP2009500442A (ja) | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| US8119693B2 (en) | 2007-05-08 | 2012-02-21 | Sanford-Burnham Medical Research Institute | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification |
| WO2013126608A1 (en) * | 2012-02-22 | 2013-08-29 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as tnap inhibitors |
-
2016
- 2016-07-07 TW TW105121542A patent/TWI702220B/zh active
- 2016-07-07 HR HRP20192121TT patent/HRP20192121T1/hr unknown
- 2016-07-07 DK DK16775006T patent/DK3319970T3/da active
- 2016-07-07 PL PL16775006T patent/PL3319970T3/pl unknown
- 2016-07-07 PT PT167750066T patent/PT3319970T/pt unknown
- 2016-07-07 CN CN201680006507.5A patent/CN107207527B/zh active Active
- 2016-07-07 RS RS20191522A patent/RS59594B1/sr unknown
- 2016-07-07 RU RU2017117179A patent/RU2715704C2/ru active
- 2016-07-07 SI SI201630466T patent/SI3319970T1/sl unknown
- 2016-07-07 CA CA2962795A patent/CA2962795C/en active Active
- 2016-07-07 ES ES16775006T patent/ES2754480T3/es active Active
- 2016-07-07 US US15/314,887 patent/US9920068B2/en active Active
- 2016-07-07 KR KR1020177010518A patent/KR102590067B1/ko active Active
- 2016-07-07 JP JP2017556523A patent/JP6666928B2/ja active Active
- 2016-07-07 SM SM20190666T patent/SMT201900666T1/it unknown
- 2016-07-07 WO PCT/US2016/041345 patent/WO2017007943A1/en not_active Ceased
- 2016-07-07 EP EP16775006.6A patent/EP3319970B1/en active Active
- 2016-07-07 HU HUE16775006A patent/HUE046994T2/hu unknown
- 2016-07-07 AU AU2016291163A patent/AU2016291163B2/en active Active
- 2016-07-07 SG SG11201701378WA patent/SG11201701378WA/en unknown
- 2016-07-07 MX MX2017003822A patent/MX2017003822A/es active IP Right Grant
- 2016-07-07 MY MYPI2017700569A patent/MY185558A/en unknown
- 2016-07-07 LT LT16775006T patent/LT3319970T/lt unknown
-
2017
- 2017-03-07 IL IL251005A patent/IL251005B/en active IP Right Grant
- 2017-03-13 ZA ZA2017/01783A patent/ZA201701783B/en unknown
- 2017-04-06 US US15/481,151 patent/US9879032B2/en active Active
- 2017-04-20 CO CONC2017/0003830A patent/CO2017003830A2/es unknown
-
2018
- 2018-01-05 PH PH12018500066A patent/PH12018500066A1/en unknown
- 2018-01-18 US US15/874,768 patent/US10221195B2/en active Active
-
2019
- 2019-11-27 CY CY20191101247T patent/CY1122477T1/el unknown
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