LT2959005T - Medicininis naudojimas, susijęs su telomerų ilgėjimu - Google Patents

Medicininis naudojimas, susijęs su telomerų ilgėjimu

Info

Publication number
LT2959005T
LT2959005T LTEPPCT/US2014/017867T LT14017867T LT2959005T LT 2959005 T LT2959005 T LT 2959005T LT 14017867 T LT14017867 T LT 14017867T LT 2959005 T LT2959005 T LT 2959005T
Authority
LT
Lithuania
Prior art keywords
telomer
extension
medical use
use related
medical
Prior art date
Application number
LTEPPCT/US2014/017867T
Other languages
English (en)
Inventor
John Ramunas
Eduard YAKUBOV
Helen M. Blau
John Cooke
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51388399&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2959005(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of LT2959005T publication Critical patent/LT2959005T/lt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
LTEPPCT/US2014/017867T 2013-02-22 2014-02-22 Medicininis naudojimas, susijęs su telomerų ilgėjimu LT2959005T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361768047P 2013-02-22 2013-02-22
PCT/US2014/017867 WO2014130909A1 (en) 2013-02-22 2014-02-22 Compounds, compositions, methods, and kits relating to telomere extension

Publications (1)

Publication Number Publication Date
LT2959005T true LT2959005T (lt) 2022-01-25

Family

ID=51388399

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2014/017867T LT2959005T (lt) 2013-02-22 2014-02-22 Medicininis naudojimas, susijęs su telomerų ilgėjimu

Country Status (21)

Country Link
US (6) US10525075B2 (lt)
EP (2) EP3988112B1 (lt)
JP (3) JP2016514953A (lt)
CN (3) CN117838716A (lt)
AU (1) AU2014218667A1 (lt)
CA (1) CA2902237C (lt)
CY (1) CY1125092T1 (lt)
DK (1) DK2959005T3 (lt)
ES (2) ES3047667T3 (lt)
FI (1) FI2959005T3 (lt)
HK (1) HK1218934A1 (lt)
HR (1) HRP20211842T1 (lt)
HU (1) HUE056638T2 (lt)
IL (2) IL296870A (lt)
LT (1) LT2959005T (lt)
PL (1) PL2959005T3 (lt)
PT (1) PT2959005T (lt)
RS (1) RS62824B1 (lt)
RU (2) RU2022101438A (lt)
SI (1) SI2959005T1 (lt)
WO (1) WO2014130909A1 (lt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2624139C2 (ru) 2011-12-05 2017-06-30 Фэктор Байосайенс Инк. Способы и препараты для трансфекции клеток
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
CN104507961B (zh) 2012-05-11 2018-08-14 珍白斯凯尔有限公司 抗炎性肽及包含其的组合物
ES2981865T3 (es) 2012-07-11 2024-10-10 Gemvax & Kael Co Ltd Conjugado que comprende un péptido de penetración celular y composiciones que comprenden el mismo
MX363017B (es) 2012-11-01 2019-03-04 Factor Bioscience Inc Métodos y productos para la expresión de proteínas en células.
RU2022101438A (ru) 2013-02-22 2022-02-11 Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити Соединения, композиции, способы и наборы, связанные с удлинением теломер
WO2015066377A1 (en) 2013-10-30 2015-05-07 The Curators Of The University Of Missouri Method for scalable skeletal muscle lineage specification and cultivation
US11058744B2 (en) 2013-12-17 2021-07-13 Gemvax & Kael Co., Ltd. Composition for treating prostate cancer
JP2017510542A (ja) 2014-01-31 2017-04-13 ファクター バイオサイエンス インコーポレイテッド 核酸生成及び送達のための方法及び製品
KR102413243B1 (ko) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물
IL253149B2 (en) 2014-12-29 2023-11-01 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
EP3543339A1 (en) 2015-02-13 2019-09-25 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
JP6751097B2 (ja) * 2015-02-27 2020-09-02 ジェムバックス アンド カエル カンパニー，リミティド 聴力損傷予防用ペプチド及びそれを含む組成物
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
DE112016002962T5 (de) 2015-06-30 2018-05-24 Ethris Gmbh Familie der ATP-bindenden Kassetten-codierende Polyribonucleotide und Formulierungen derselben
EP3318265B1 (en) 2015-07-02 2021-08-18 Gemvax & Kael Co., Ltd. Peptide having anti-viral effect and composition containing same
AU2016297014B2 (en) 2015-07-21 2021-06-17 Novartis Ag Methods for improving the efficacy and expansion of immune cells
CN113476589A (zh) * 2015-11-03 2021-10-08 珍白斯凯尔有限公司 肽在制造用于治疗神经退行性疾病的组合物中的用途
US20180360924A1 (en) * 2015-11-25 2018-12-20 The Methodist Hospital System Telomere extension and anti-inflammatory agents for cell regeneration
AU2016380262B2 (en) 2015-12-28 2023-02-09 Novartis Ag Methods of making chimeric antigen receptor -expressing cells
EP4272829A3 (en) 2016-04-07 2024-01-17 Gemvax & Kael Co., Ltd. Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same
WO2017221225A1 (en) * 2016-06-19 2017-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
CA3033788A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
EP3612623B1 (en) 2017-05-06 2024-07-03 Upside Foods, Inc. Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure
EP3638777A4 (en) 2017-07-13 2021-05-12 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICIENCY OF CELL CULTURES FOR FOOD MANUFACTURING
RU2020116579A (ru) 2017-10-25 2021-11-25 Новартис Аг Способы получения клеток, экспрессирующих химерный антигенный рецептор
JP7474702B2 (ja) 2018-03-28 2024-04-25 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法
EP3844265A2 (en) 2018-08-31 2021-07-07 Novartis AG Methods of making chimeric antigen receptor-expressing cells
EP3844267B1 (en) 2018-08-31 2025-06-25 Novartis AG Methods of making chimeric antigen receptor-expressing cells
CA3109063A1 (en) * 2018-09-06 2020-03-12 The Board Of Regents Of The University Of Texas System Telomerase holoenzyme complex and methods of use thereof
KR102209234B1 (ko) * 2018-10-02 2021-02-01 주식회사 스템온 세포의 텔로미어를 신장시키는 방법
WO2020071652A1 (ko) 2018-10-02 2020-04-09 주식회사 스템온 세포의 텔로미어를 신장시키는 방법
WO2020071665A2 (ko) * 2018-10-02 2020-04-09 주식회사 스템온 세포의 텔로미어를 신장시키는 조성물 및 그 제조방법
KR20210125530A (ko) * 2019-02-08 2021-10-18 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 노화 및 연령-관련 기관 기능부전과 연관된 질환을 치료하기 위한 텔로머라제-함유 엑소좀
US20220168389A1 (en) 2019-04-12 2022-06-02 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
JP7716987B2 (ja) * 2019-05-02 2025-08-01 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｔｅｒｔ活性化療法を伴う方法および組成物
US12344572B2 (en) 2019-07-03 2025-07-01 Factor Bioscience Inc. Cationic lipids and transfection methods
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
CN114761037A (zh) 2019-11-26 2022-07-15 诺华股份有限公司 结合bcma和cd19的嵌合抗原受体及其用途
AU2021205410A1 (en) * 2020-01-10 2022-09-08 Andranik Andrew Aprikyan Nanoparticles for expression of genes of interest and/or regulation of signaling pathways
CA3171331A1 (en) * 2020-02-17 2021-08-26 Figene, Llc Telomere length modulation using fibroblasts
BR112022016633A2 (pt) 2020-02-27 2022-12-13 Novartis Ag Métodos para produzir células que expressam receptor de antígeno quimérico
CN116870195A (zh) * 2020-09-22 2023-10-13 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
WO2022147039A1 (en) * 2020-12-29 2022-07-07 Rejuvenation Technologies Inc. Compositions and methods for delivery of rna
EP4312942A4 (en) * 2021-03-31 2025-03-19 Rejuvenation Technologies Inc. Compositions and methods for delivery of RNA
CN115678904B (zh) * 2021-07-22 2025-12-09 刘小川 一种突变的人端粒酶rna基因及其在预防和治疗泛癌种中的应用
JP2025531220A (ja) 2022-09-15 2025-09-19 ノバルティス アーゲー キメラ抗原受容体療法を使用した自己免疫障害の治療
CN117530952A (zh) * 2023-07-19 2024-02-09 南京医科大学 一种囊胚期移植恢复端粒长度的动物模型构建方法及用途
EP4644561A1 (en) * 2024-05-03 2025-11-05 Hochschule für Technik und Wirtschaft (HTW) Berlin Optical, cell-based, high-throughput capable method for the determination of telomere length and dynamics in yeast

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686306A (en) 1992-05-13 1997-11-11 Board Of Regents, The University Of Texas System Methods and reagents for lengthening telomeres
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5770422A (en) 1996-07-08 1998-06-23 The Regents Of The University Of California Human telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
EP0841396B2 (en) 1996-10-01 2012-04-11 Geron Corporation Human telomerase catalytic subunit
US8323975B2 (en) * 2002-01-04 2012-12-04 The Board Of Trustees Of The Leland Stanford Junior University Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
US7897752B2 (en) 2002-02-20 2011-03-01 Sirna Therapeutics, Inc. RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
KR101298493B1 (ko) 2003-09-09 2013-08-21 제론 코포레이션 텔로머라제 억제를 위한 변형 올리고뉴클레오티드
DE102004035227A1 (de) * 2004-07-21 2006-02-16 Curevac Gmbh mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen
RS63964B1 (sr) 2005-08-23 2023-03-31 Univ Pennsylvania Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu
US9012219B2 (en) 2005-08-23 2015-04-21 The Trustees Of The University Of Pennsylvania RNA preparations comprising purified modified RNA for reprogramming cells
US20090032427A1 (en) 2005-09-29 2009-02-05 Nektar Therapeutics Receptacles and Kits, Such as for Dry Powder Packaging
GB0720486D0 (en) 2007-10-19 2007-11-28 Univ Edinburgh Cationic lipids
WO2010036813A1 (en) 2008-09-24 2010-04-01 University Of South Florida Materials and methods for preventing or treating neurodegenerative conditions associated with abeta peptide accumulation
SI3112467T1 (en) 2009-12-07 2018-06-29 The Trustees Of The University Of Pennsylvania Rna preparations comprising purified modified rna for reprogramming cells
RU2443777C2 (ru) * 2010-03-24 2012-02-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической иммунологии Сибирского отделения РАМН Способ одномоментного определения длины теломер и количества делений популяции пролиферирующих клеток in vitro
EP2558571A4 (en) 2010-04-16 2014-09-24 Immune Disease Inst Inc DELAYED POLYPEPTIDE EXPRESSION FROM MODIFIED SYNTHETIC RNAS AND USES THEREOF
US20120177611A1 (en) 2010-07-15 2012-07-12 Blau Helen M Elastic substrates and methods of use in cell manipulation and culture
CN102433297A (zh) * 2011-10-14 2012-05-02 黄必录 延伸成体多能干细胞端粒的方法
RU2624139C2 (ru) 2011-12-05 2017-06-30 Фэктор Байосайенс Инк. Способы и препараты для трансфекции клеток
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
RU2022101438A (ru) 2013-02-22 2022-02-11 Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити Соединения, композиции, способы и наборы, связанные с удлинением теломер
JP6123561B2 (ja) 2013-08-08 2017-05-10 ソニー株式会社 発光素子及びその製造方法、並びに、表示装置

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