LT2661B - Peptidilglicinines alpha-amiduojancios monooksigenazes isvalymo budas ir alpha-amiduoto peptido gavimo budas - Google Patents

Peptidilglicinines alpha-amiduojancios monooksigenazes isvalymo budas ir alpha-amiduoto peptido gavimo budas

Info

Publication number
LT2661B
LT2661B LTRP1130A LTRP1130A LT2661B LT 2661 B LT2661 B LT 2661B LT RP1130 A LTRP1130 A LT RP1130A LT RP1130 A LTRP1130 A LT RP1130A LT 2661 B LT2661 B LT 2661B
Authority
LT
Lithuania
Prior art keywords
alpha
enzyme
peptidilglic
monooksigenaze
amided
Prior art date
Application number
LTRP1130A
Other languages
English (en)
Lithuanian (lt)
Inventor
James P Gilligan
Barry N Drive
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24628603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2661(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Publication of LT2661B publication Critical patent/LT2661B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003—Peptidylglycine monooxygenase (1.14.17.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LTRP1130A 1984-09-27 1993-09-27 Peptidilglicinines alpha-amiduojancios monooksigenazes isvalymo budas ir alpha-amiduoto peptido gavimo budas LT2661B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/655,366 US4708934A (en) 1984-09-27 1984-09-27 α-amidation enzyme

Publications (1)

Publication Number Publication Date
LT2661B true LT2661B (lt) 1994-04-25

Family

ID=24628603

Family Applications (1)

Application Number Title Priority Date Filing Date
LTRP1130A LT2661B (lt) 1984-09-27 1993-09-27 Peptidilglicinines alpha-amiduojancios monooksigenazes isvalymo budas ir alpha-amiduoto peptido gavimo budas

Country Status (13)

Country Link
US (1) US4708934A (pt)
EP (1) EP0201511B1 (pt)
JP (1) JP2594037B2 (pt)
AT (1) ATE92522T1 (pt)
CA (1) CA1341037C (pt)
DE (1) DE3587506T2 (pt)
DK (1) DK241486D0 (pt)
FI (1) FI100993B1 (pt)
HU (1) HU195857B (pt)
LT (1) LT2661B (pt)
NO (1) NO862100L (pt)
RU (1) RU1802814C (pt)
WO (1) WO1986002099A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319685B1 (en) * 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
DE3612302A1 (de) * 1986-04-11 1987-10-15 Hoechst Ag Chromophore peptide, verfahren zu ihrer herstellung und ihre verwendung zum nachweis der peptidylglycin-(alpha)-amidierenden monooxygenase
JPH0775541B2 (ja) * 1986-06-07 1995-08-16 壽之 松尾 Ｃ末端アミド化酵素及びその製造方法
JP2598050B2 (ja) 1987-07-17 1997-04-09 サントリー株式会社 Ｃ−末端α−アミド化酵素
US5821083A (en) * 1987-07-17 1998-10-13 Suntory Limited Recombinant C-terminal α-amidating enzyme
US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US6255067B1 (en) * 1987-09-15 2001-07-03 The Johns Hopkins University cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)
JP2653820B2 (ja) * 1988-03-14 1997-09-17 壽之 松尾 アミド化酵素及びその製造方法
KR920700283A (ko) * 1988-05-30 1992-02-19 후쿠하라 요시하루 C-말단 아미드화 효소 조성물, 제조방법 및 이의 사용방법
JP2512575B2 (ja) * 1988-05-30 1996-07-03 株式会社資生堂 Ｃ末端アミド化酵素組成物、調製方法および使用
JP2845468B2 (ja) * 1989-01-17 1999-01-13 サントリー株式会社 ヒト甲状腺由来Ｃ―末端α―アミド化酵素
US5871995A (en) * 1989-08-15 1999-02-16 Shiseido Company, Ltd. Purified enzymes participating in C-terminal amidation
EP0448513A3 (en) * 1990-03-21 1991-12-27 Japat Ltd Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
JP2774769B2 (ja) * 1993-04-26 1998-07-09 賢治 寒川 アドレノメデュリン
WO1997013410A1 (en) * 1995-10-13 1997-04-17 Boston Medical Center Corporation Hybrid molecules containing amidated polypeptide binding ligands
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
RU2218407C2 (ru) 1997-04-16 2003-12-10 Юниджен Лэбораториз Инк. Прямая экспрессия пептидов в культуральные среды
US6507788B1 (en) 1999-02-25 2003-01-14 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
DE102004058306A1 (de) * 2004-12-01 2006-07-27 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP4856177B2 (ja) * 2005-06-24 2012-01-18 ユニジーン・ラボラトリーズ・インコーポレーテッド アミド化生成物の調製に有用な酵素を発現させるための細胞株
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
US8222016B2 (en) * 2007-06-29 2012-07-17 Daiichi Sankyo Company, Limited Recombinant C-terminal α-amidating enzyme derivative
JP5753097B2 (ja) 2009-01-22 2015-07-22 ユニジーン・ラボラトリーズ・インコーポレーテッド 肥満の治療
ES2583259T3 (es) 2009-12-01 2016-09-20 Novo Nordisk A/S Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
CN103764669B (zh) 2011-06-15 2017-08-15 雷索特制药公司 抗炎药物产品
ES2673617T3 (es) 2011-11-02 2018-06-25 Keybioscience Ag Miméticos de calcitonina para tratar enfermedades y trastornos
US9533022B2 (en) 2011-11-02 2017-01-03 KeyBioscience A/S Peptide analogs for treating diseases and disorders
CN103998052B (zh) 2011-11-02 2016-08-17 关键生物科学有限公司 用于治疗疾病和紊乱的肽类似物
LT3321278T (lt) 2013-11-14 2019-03-12 Keybioscience Ag Kalcitonino mimetikai, skirti ligų ir sutrikimų gydymui
WO2015084875A1 (en) 2013-12-02 2015-06-11 Stealth Peptides International, Inc. Compositions and methods for treating vitiligo
US10576124B2 (en) 2014-05-28 2020-03-03 Stealth Biotherapeutics Corp Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
EP3149035A4 (en) 2014-05-28 2018-05-16 Stealth BioTherapeutics Corp Therapeutic compositions including therapeutic small molecules and uses thereof
US10627392B2 (en) 2014-06-17 2020-04-21 Stealth Biotherapeutics Corp Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening
GB201500263D0 (en) 2015-01-08 2015-02-25 Keybioscience Ag Calcitonin analogues for treating diseases and disorders
KR102294577B1 (ko) 2015-01-12 2021-08-26 엔터리스 바이오파마, 인크. 고체 경구 제형
EP3256144B1 (en) 2015-02-13 2021-03-24 The Board of Trustees of the University of Illionis Peptide inhibition of ccr3-mediated diseases or conditions
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
JP2022543056A (ja) 2019-07-29 2022-10-07 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 創傷治癒を促進するための組成物および方法
GB202001024D0 (en) 2020-01-24 2020-03-11 Key Bioscience Ag Oxyntomodulin mimetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319685B1 (en) * 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use

Also Published As

Publication number Publication date
AU4802785A (en) 1986-04-17
AU594026B2 (en) 1990-03-01
CA1341037C (en) 2000-06-27
DE3587506T2 (de) 1994-01-13
JPS62500560A (ja) 1987-03-12
RU1802814C (ru) 1993-03-15
HUT41444A (en) 1987-04-28
ATE92522T1 (de) 1993-08-15
NO175214B (pt) 1994-06-06
FI100993B1 (fi) 1998-03-31
FI94361C (fi) 1995-08-25
WO1986002099A1 (en) 1986-04-10
EP0201511A4 (en) 1988-05-31
DE3587506D1 (en) 1993-09-09
FI94361B (fi) 1995-05-15
NO175214C (pt) 1994-09-14
JP2594037B2 (ja) 1997-03-26
HU195857B (en) 1988-07-28
FI862216A (fi) 1986-05-26
EP0201511A1 (en) 1986-11-20
US4708934A (en) 1987-11-24
NO862100L (no) 1986-05-27
DK241486A (da) 1986-05-23
FI862216A0 (fi) 1986-05-26
DK241486D0 (da) 1986-05-23
EP0201511B1 (en) 1993-08-04

Similar Documents

Publication Publication Date Title
LT2661B (lt) Peptidilglicinines alpha-amiduojancios monooksigenazes isvalymo budas ir alpha-amiduoto peptido gavimo budas
Barra et al. The primary structure of human liver manganese superoxide dismutase.
KITAHARA et al. Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits
Briand et al. Investigation of the requirements for O-glycosylation by bovine submaxillary gland UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosamine transferase using synthetic peptide substrates.
IE890873L (en) Biologically Active Material Characterised by Catabolic Activity Generally Associated with Cachexia Inducing Tumours, Preparations, Production and Uses Thereof
Keeran et al. The purification and characterization of glutathione S-transferase from the hepatopancreas of the blue crab, Callinectes sapidus
Tanaka et al. The primary structure of bovine adrenodoxin
Pouluse et al. Primary structure of a chymotryptic peptide containing the “active serine” of the thioesterase domain of fatty acid synthase
Schleicher et al. Isolation and characterization of calmodulin from the motile green alga Chlamydomonas reinhardtii
KÖST‐REYES et al. The Protein‐Chromophore Bond in B Phycoerythrin from Porphyridium cruentum: Radiosulfur Labeling Experiments
KR940009329A (ko) 딕티오스텔륨 디펩티딜아미노펩티다아제
ES2003180A6 (es) Un metodo para preparar un polipeptido capaz de modular la actividad del crecimiento.
GB2188934B (en) Polypeptide production using an amidating enzyme
Pohl et al. Isolation and characterization of cathepsin D from human gastric mucosa
Briley et al. The primary structure of Escherichia coli K12 aspartokinase I-homoserine dehydrogenase I. Site of limited proteolytic cleavage by subtilisin.
EP0354652A3 (en) Novel alpha-n-acetylgalactosaminyltransferase and method of detecting tumour cells using same
ES8300853A1 (es) Procedimiento de inmovilizacion de celulas microbianas glo- bulares por adhesion a un soporte solido
EP0290029A3 (en) (19-alanine) calcitonin
Samejima et al. Complete Amino Acid Sequence of Snake Venom Phospholipase A2
ES8707796A1 (es) Metodo para la cuantificacion del antigeno procoagulante delcancer en una muestra biologica
MOSOLOV Protein inhibitors as regulators of proteolysis processes(Russian book)
GB8906796D0 (en) Method of enhancing neutralising antibody activity in human or animal sera or in other body secretions
KR870011245A (ko) α-아미드화 효소

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20000826