KR970069997A - 2,3-벤조디아제핀 유도체 - Google Patents
2,3-벤조디아제핀 유도체 Download PDFInfo
- Publication number
- KR970069997A KR970069997A KR1019970012301A KR19970012301A KR970069997A KR 970069997 A KR970069997 A KR 970069997A KR 1019970012301 A KR1019970012301 A KR 1019970012301A KR 19970012301 A KR19970012301 A KR 19970012301A KR 970069997 A KR970069997 A KR 970069997A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- hydrogen
- general formula
- compound
- alkyl group
- Prior art date
Links
- RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 25
- 239000001257 hydrogen Substances 0.000 claims abstract 25
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 150000002431 hydrogen Chemical class 0.000 claims abstract 19
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 11
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims abstract 8
- 239000002253 acid Substances 0.000 claims abstract 7
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052794 bromium Inorganic materials 0.000 claims abstract 3
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 3
- 239000000460 chlorine Substances 0.000 claims abstract 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims abstract 3
- 229910052736 halogen Inorganic materials 0.000 claims abstract 3
- 150000002367 halogens Chemical class 0.000 claims abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 2
- XBLLOPDJGYDQEU-UHFFFAOYSA-N 1-(4-aminophenyl)-8-chloro-n,4-dimethyl-4,5-dihydro-2,3-benzodiazepine-3-carboxamide Chemical compound C12=CC(Cl)=CC=C2CC(C)N(C(=O)NC)N=C1C1=CC=C(N)C=C1 XBLLOPDJGYDQEU-UHFFFAOYSA-N 0.000 claims 1
- JNKMFWULKBWFBY-UHFFFAOYSA-N 1-[1-(4-aminophenyl)-8-chloro-4-methyl-4,5-dihydro-2,3-benzodiazepin-3-yl]ethanone Chemical compound N=1N(C(C)=O)C(C)CC2=CC=C(Cl)C=C2C=1C1=CC=C(N)C=C1 JNKMFWULKBWFBY-UHFFFAOYSA-N 0.000 claims 1
- 208000007101 Muscle Cramp Diseases 0.000 claims 1
- 208000005392 Spasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036963 noncompetitive effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP9600871 | 1996-04-04 | ||
| HU9600871A HU9600871D0 (en) | 1996-04-04 | 1996-04-04 | New 2,3-benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR970069997A true KR970069997A (ko) | 1997-11-07 |
Family
ID=89993864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019970012301A KR970069997A (ko) | 1996-04-04 | 1997-04-03 | 2,3-벤조디아제핀 유도체 |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR970069997A (de) |
| AT (1) | ATE254608T1 (de) |
| AU (1) | AU720745B2 (de) |
| BE (1) | BE1010962A4 (de) |
| DE (1) | DE59711013D1 (de) |
| ES (1) | ES2127699B1 (de) |
| IT (1) | IT1290453B1 (de) |
| NZ (1) | NZ314517A (de) |
| UA (1) | UA45358C2 (de) |
| YU (1) | YU13197A (de) |
| ZA (1) | ZA972746B (de) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
| HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
| HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| HU208429B (en) * | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity |
| EP1157992B1 (de) * | 1994-08-31 | 2005-08-24 | Eli Lilly And Company | Dihydro-2,3-Benzodiazepinderivate |
-
1997
- 1997-04-01 ZA ZA972746A patent/ZA972746B/xx unknown
- 1997-04-03 BE BE9700308A patent/BE1010962A4/fr not_active IP Right Cessation
- 1997-04-03 YU YU13197A patent/YU13197A/sh unknown
- 1997-04-03 UA UA97041584A patent/UA45358C2/uk unknown
- 1997-04-03 NZ NZ314517A patent/NZ314517A/xx unknown
- 1997-04-03 KR KR1019970012301A patent/KR970069997A/ko not_active Application Discontinuation
- 1997-04-04 ES ES009700703A patent/ES2127699B1/es not_active Expired - Fee Related
- 1997-04-04 IT IT000776 patent/IT1290453B1/it active IP Right Grant
- 1997-04-04 AU AU17734/97A patent/AU720745B2/en not_active Ceased
- 1997-04-04 DE DE59711013T patent/DE59711013D1/de not_active Expired - Fee Related
- 1997-04-04 AT AT97105591T patent/ATE254608T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2127699A1 (es) | 1999-04-16 |
| ATE254608T1 (de) | 2003-12-15 |
| ES2127699B1 (es) | 2000-01-16 |
| ITMI970776A1 (it) | 1998-10-04 |
| AU720745B2 (en) | 2000-06-08 |
| ZA972746B (en) | 1998-10-09 |
| NZ314517A (en) | 2000-03-27 |
| IT1290453B1 (it) | 1998-12-03 |
| YU13197A (sh) | 1999-09-27 |
| DE59711013D1 (de) | 2003-12-24 |
| AU1773497A (en) | 1997-10-09 |
| UA45358C2 (uk) | 2002-04-15 |
| BE1010962A4 (fr) | 1999-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |