KR970032870A - 항산화제로서의 8,9-데하이드로에스트론의 용도 - Google Patents

항산화제로서의 8,9-데하이드로에스트론의 용도 Download PDF

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KR970032870A
KR970032870A KR1019960061345A KR19960061345A KR970032870A KR 970032870 A KR970032870 A KR 970032870A KR 1019960061345 A KR1019960061345 A KR 1019960061345A KR 19960061345 A KR19960061345 A KR 19960061345A KR 970032870 A KR970032870 A KR 970032870A
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South Korea
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dehydroestrone
salt
pharmaceutically acceptable
sulfate
inhibiting
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KR1019960061345A
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KR100444002B1 (ko
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히토시 엔도우
카주하루 이에나가
도시히꼬 후지와라
마사아끼 미야모또
히로요시 호리꼬시
마사후미 기다카제
스티븐 제이 아델맨
Original Assignee
코니시 진우에몬
닛폰조키세야쿠 카부시키가이샤
원본미기재
상꾜 가부시끼가이샤
가와구치 시게키
오쓰카 세이야쿠 가부시키가이샤
버그 이곤 이
아메리칸 홈 프로덕츠 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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Abstract

본 발명은 항산화제로서 8,9-데하이드로에스트론 또는 8,9-데하이드로에스트론-3-설페이트 에스테르의 약제학적으로 허용되는 염을 사용하는 방법을 제공한다.

Description

항산화제로서의 8,9-데하이드로에스트론의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 항산화량의 8,9-데하이드로에스트론 또는 8,9-데하이드로에스트론-3-설페이트 에스테르의 약제학적으로 허용되는 염을 유리 라디칼에 의해 유도된 질병의 억제 또는 치료를 필요로 하는 포유동물에 투여하는 단계를 포함하여, 상기 질병을 억제 또는 치료하는 방법.
  2. 제 1항에 있어서, 3-설페이트 에스테르의 약제학적으로 허용되는 염이 알칼리 금속 염, 알칼리 토금속 염, 암모늄 염, 탄소수 1내지 6의 알킬아민 염 또는 각 알킬 그룹의 탄소수가 1 내지 6인 디알킬아민 염인 방법.
  3. 포유동물의 효소, 이온 채널, 구조 단백질 또는 막지질과 선택적으로 반응하고 유리 라디칼 반응을 억제하기에 충분한 양으로 대용 기질로서 8,9-데하이드로에스트론 또는 8,9-데하이드로에스트론-3-설페이트 에스테르의 약제학적으로 허용되는 염을 투여하는 단계를 포함하여, 효소, 이온 채널, 구조 단백질 및 막지질과의 유리 라디칼 반응의 억제 치료가 필요한 포유동물에서 상기 반응을 억제시키는 방법.
  4. 8,9-데하이드로에스트론 또는 8,9-데하이드로에스트론-3-설페이트 에스테르의 약제학적으로 허용되는 염을 투여하는 단계를 포함하여, 암, 중추신경계 장애, 골(bone) 질병, 노화, 염증성 장애, 말초 혈관 장애, 류마티스성 관절염, 자가면역 질병, 호흡곤란, 폐기종, 재관류 상해의 방지, 바이러스성 간염, 만성 활성 간염, 결핵, 건선, 전신성 홍반성낭창, 성인 호흡곤란증후군, 중추신경계 외상 및 발작 또는 재관류 과정동안 상해의 발병시 내인성 유리 라디칼 반응을 억제하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960061345A 1995-12-04 1996-12-03 항산화제로서8,9-데하이드로에스트론을포함하는약제학적조성물 KR100444002B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US793195P 1995-12-04 1995-12-04
US60/007,931 1995-12-04
US08/570,767 1995-12-12
JP95-349831 1995-12-20
JP95-338440 1995-12-26

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KR970032870A true KR970032870A (ko) 1997-07-22
KR100444002B1 KR100444002B1 (ko) 2004-11-03

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EP (1) EP0778025B1 (ko)
JP (1) JPH09169650A (ko)
KR (1) KR100444002B1 (ko)
CN (1) CN1104900C (ko)
AR (2) AR005866A1 (ko)
AT (1) ATE263565T1 (ko)
AU (1) AU703814B2 (ko)
BR (1) BR9605777A (ko)
CA (1) CA2191835A1 (ko)
CZ (1) CZ289780B6 (ko)
DE (1) DE69632117T2 (ko)
DK (1) DK0778025T3 (ko)
ES (1) ES2215187T3 (ko)
HK (1) HK1010095A1 (ko)
HU (1) HUP9603329A3 (ko)
IL (1) IL119744A (ko)
MX (1) MX9606009A (ko)
NO (1) NO312654B1 (ko)
NZ (1) NZ299858A (ko)
PT (1) PT778025E (ko)
SI (1) SI0778025T1 (ko)
SK (1) SK154296A3 (ko)
ZA (1) ZA969923B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723794A1 (de) * 1997-06-06 1998-12-10 Jenapharm Gmbh Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
US7368542B2 (en) 2003-06-09 2008-05-06 Redox-Reactive Reagents Llc Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions
US9557325B2 (en) 2003-06-09 2017-01-31 Redox-Reactive Reagents Llc Method of altering the binding specificity of proteins by oxidation-reduction reactions
US7892751B2 (en) 2003-06-09 2011-02-22 Redox-Reactive Reagents Llc Method of detecting or diagnosing of a neurodegenerative disease or condition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210081A (en) * 1992-02-26 1993-05-11 American Home Products Corporation Alkali metal 8,9-dehydroestrone sulfate esters
DE4334823C2 (de) * 1993-10-09 1998-09-17 Schering Ag Verfahren zur Herstellung von Schwefelsäurehalbestern von Estrogenen
US5395831A (en) * 1994-04-08 1995-03-07 American Home Products Corporation Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone
DE19509729A1 (de) * 1995-03-13 1996-09-19 Schering Ag 17-Difluormethylen-Estratriene

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CA2191835A1 (en) 1997-06-05
IL119744A (en) 2003-01-12
DK0778025T3 (da) 2004-06-07
PT778025E (pt) 2004-08-31
BR9605777A (pt) 1998-08-25
AR005866A1 (es) 1999-07-21
EP0778025B1 (en) 2004-04-07
IL119744A0 (en) 1997-03-18
NZ299858A (en) 2001-03-30
NO965165D0 (no) 1996-12-03
NO312654B1 (no) 2002-06-17
ATE263565T1 (de) 2004-04-15
AR059965A2 (es) 2008-05-14
SK154296A3 (en) 1997-08-06
ZA969923B (en) 1998-05-26
DE69632117D1 (de) 2004-05-13
CZ289780B6 (cs) 2002-04-17
NO965165L (no) 1997-06-05
HUP9603329A2 (en) 1997-08-28
HU9603329D0 (en) 1997-01-28
HK1010095A1 (en) 1999-06-11
ES2215187T3 (es) 2004-10-01
KR100444002B1 (ko) 2004-11-03
CZ353296A3 (en) 1997-08-13
HUP9603329A3 (en) 1998-01-28
SI0778025T1 (en) 2004-08-31
CN1158725A (zh) 1997-09-10
DE69632117T2 (de) 2004-08-26
AU703814B2 (en) 1999-04-01
MX9606009A (es) 1997-08-30
CN1104900C (zh) 2003-04-09
EP0778025A1 (en) 1997-06-11
AU7194496A (en) 1997-06-12
JPH09169650A (ja) 1997-06-30

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