MXPA94001822A - Derivados de acido aciloxihexanoico. - Google Patents

Derivados de acido aciloxihexanoico.

Info

Publication number
MXPA94001822A
MXPA94001822A MXPA94001822A MX9401822A MXPA94001822A MX PA94001822 A MXPA94001822 A MX PA94001822A MX PA94001822 A MXPA94001822 A MX PA94001822A MX 9401822 A MX9401822 A MX 9401822A MX PA94001822 A MXPA94001822 A MX PA94001822A
Authority
MX
Mexico
Prior art keywords
acyloxyhexanoic
acid derivative
radical
heteroatom
unsubstituted
Prior art date
Application number
MXPA94001822A
Other languages
English (en)
Inventor
Bhagwat Shripad
Original Assignee
Novartis Ag Tambien Denominada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag Tambien Denominada filed Critical Novartis Ag Tambien Denominada
Publication of MXPA94001822A publication Critical patent/MXPA94001822A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describen compuestos de la formula I': (Ver Formula); en donde T es un radical de acilo de la formula Z: (Ver Formula); en donde: Rz es hidrocarbilo insustituido o sustituido, en donde cuando menos un atomo de carbono ha sido remplazado por un heteroatomo, con la condicion de que no se enlace el heteroatomo directamente con el carbonilo con el que se enlaza el radical Rz, alquilo que tiene dos o mas atomos de carbono, alquenilo inferior, alquinilo inferior, arilo o amino insustituido o sustituido, y en donde los radicales R1, B1, R2, R3, A1, A2, y NR4R5, son como se definen en la descripcion, y precursores de los mismos. Los compuestos tienen actividad farmaceutica, por ejemplo, en el tratamiento del SIDA.
MXPA94001822A 1993-03-11 1994-03-11 Derivados de acido aciloxihexanoico. MXPA94001822A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH77293 1993-03-11

Publications (1)

Publication Number Publication Date
MXPA94001822A true MXPA94001822A (es) 2004-09-09

Family

ID=4194824

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA94001822A MXPA94001822A (es) 1993-03-11 1994-03-11 Derivados de acido aciloxihexanoico.

Country Status (15)

Country Link
EP (1) EP0618222A3 (es)
JP (1) JPH07316191A (es)
KR (1) KR940021577A (es)
CN (1) CN1112125A (es)
AU (1) AU678202B2 (es)
CA (1) CA2118661A1 (es)
CZ (1) CZ54194A3 (es)
FI (1) FI941064A (es)
HU (1) HUT67089A (es)
IL (1) IL108920A0 (es)
MA (1) MA23133A1 (es)
MX (1) MXPA94001822A (es)
NO (1) NO940853L (es)
NZ (1) NZ260056A (es)
ZA (1) ZA941668B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT708085E (pt) * 1994-10-19 2002-11-29 Novartis Ag Eteres antivirais de isosteros de substrato de aspartato protease
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
KR100440643B1 (ko) * 1999-01-28 2004-07-21 쥬가이 세이야쿠 가부시키가이샤 치환 페네틸아민 유도체
WO2002042259A2 (en) * 2000-11-27 2002-05-30 University Of Maryland, Baltimore Methods of synthesizing and using derivatives of [2-(2-aminoethoxy)ethoxy] acetic acid
US7479538B2 (en) 2004-11-12 2009-01-20 The Zhabilov Trust Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV
US8067531B2 (en) 2004-11-12 2011-11-29 The Zhabilov Trust Inactivated pepsin fragments for modulating immune system activity against human malignant tumor cells
US8309072B2 (en) 2004-11-12 2012-11-13 The Zhabilov Trust Irreversibly-inactivated pepsinogen fragments for modulating immune function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use

Also Published As

Publication number Publication date
CZ54194A3 (en) 1994-10-19
CA2118661A1 (en) 1994-09-12
EP0618222A3 (en) 1997-01-02
AU5758894A (en) 1994-09-15
FI941064A (fi) 1994-09-12
HU9400720D0 (en) 1994-06-28
ZA941668B (en) 1994-09-13
NO940853L (no) 1994-09-12
NZ260056A (en) 1995-12-21
MA23133A1 (fr) 1994-10-01
AU678202B2 (en) 1997-05-22
IL108920A0 (en) 1994-06-24
KR940021577A (ko) 1994-10-19
FI941064A0 (fi) 1994-03-07
CN1112125A (zh) 1995-11-22
JPH07316191A (ja) 1995-12-05
HUT67089A (en) 1995-01-30
EP0618222A2 (de) 1994-10-05
NO940853D0 (no) 1994-03-10

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