KR970009812A - 활성화 면역글로불린 - Google Patents
활성화 면역글로불린 Download PDFInfo
- Publication number
- KR970009812A KR970009812A KR1019960033064A KR19960033064A KR970009812A KR 970009812 A KR970009812 A KR 970009812A KR 1019960033064 A KR1019960033064 A KR 1019960033064A KR 19960033064 A KR19960033064 A KR 19960033064A KR 970009812 A KR970009812 A KR 970009812A
- Authority
- KR
- South Korea
- Prior art keywords
- immunoglobulin
- activated
- useful
- diseases
- agent
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title claims abstract 15
- 102000018358 immunoglobulin Human genes 0.000 title claims abstract 15
- 239000003814 drug Substances 0.000 claims abstract 11
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract 5
- 239000002260 anti-inflammatory agent Substances 0.000 claims abstract 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims abstract 3
- 239000000043 antiallergic agent Substances 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 3
- 206010014950 Eosinophilia Diseases 0.000 claims abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 claims abstract 2
- 239000002955 immunomodulating agent Substances 0.000 claims abstract 2
- 229940121354 immunomodulator Drugs 0.000 claims abstract 2
- 239000003112 inhibitor Substances 0.000 claims abstract 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 8
- 229960001340 histamine Drugs 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 1
- 230000003266 anti-allergic effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010021460 Immunodeficiency syndromes Diseases 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Abstract
호산구증다억제제, 면역조정제, 자기면역질환치료제, 항염증제, 항알레르기제로서 유용한 활성화 면역글로불린을 제공한다.
본 발명은 천연형의 면역글로불린이 본래 나타내지 않은 새로운 약리활성을 면역글로불린에 부여하는 방법, 그 방법에 의해 얻어지는 활성화 면역글로불린 및 그 활성화 면역글로불린을 유효성분으로 함유하는 의약조성물에 관한 것이다.
본 발명의 활성화 면역글로불린은 종래의 면역억제제와는 확실히 다른 면역조정작용을 보유하여 만성관절류마티스, 전신성에리스마트데스, 다발성경화증 등의 자기면역질환이든지 각종 면역부전증후군 등의 면역계가 매우 빠진 질환에 대한 치료제로서 유용하다. 또한 본 발명의 활성화 면역글로불린은, 감염증, 기생충질환, 호흡기질환, 자기면역질환, 악성종양 등에 따른 호산구과다증에 대한 약제로서, 또한 우수한 항염증제나 항알레르기제로서도 이용할 수 있어 매우 유용성이 높다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 활성화 면역글로불린.
- 제 1항에 있어서, 호산구증다억제작용, 면역조정작용, 자기면역질환 개선작용, 항염증작용 또는 항알레르기작용을 보유하는 활성화 면역글로불린.
- 제 1항에 있어서, 면역글로불린을 히스타민성분과 혼합처리한 후에 히스타민을 제거하는 활성화조직에 의해 얻어진 활성화 면역글로불린.
- 제 1항 기재의 활성화 면역글로불린을 함유하는 의약.
- 제 4항에 있어서, 호산구증다억제제인 것을 특징으로 하는 의약.
- 제 4항에 있어서, 면역조정제인 것을 특징으로 하는 의약.
- 제 4항에 있어서, 자기면역질환치료제인 것을 특징으로 하는 의약.
- 제 4항에 있어서, 항염증제인 것을 특징으로 하는 의약.
- 제 4항에 있어서, 항알레르기제인 것을 특징으로 하는 의약.
- 제 4항에 있어서, 주사제인 것을 특징으로 하는 의약.
- 제 4항에 있어서, 경구제인 것을 특징으로 하는 의약.
- 면역글로불린을 히스타민성분과 혼합처리한 후에 히스타민을 제거하는 면역글로불린의 활성화방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7227045A JPH0959180A (ja) | 1995-08-11 | 1995-08-11 | 活性化免疫グロブリン |
JP95-227045 | 1995-08-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970009812A true KR970009812A (ko) | 1997-03-27 |
KR100436811B1 KR100436811B1 (ko) | 2004-08-25 |
Family
ID=16854669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960033064A KR100436811B1 (ko) | 1995-08-11 | 1996-08-08 | 활성화면역글로불린 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6627194B1 (ko) |
EP (1) | EP0758656B1 (ko) |
JP (1) | JPH0959180A (ko) |
KR (1) | KR100436811B1 (ko) |
CN (1) | CN1108818C (ko) |
AT (1) | ATE252603T1 (ko) |
AU (1) | AU713296B2 (ko) |
CA (1) | CA2183020A1 (ko) |
DE (1) | DE69630423T2 (ko) |
TW (1) | TW442495B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10212246A (ja) | 1997-01-30 | 1998-08-11 | Nippon Zoki Pharmaceut Co Ltd | 経口投与用製剤 |
CA2232420A1 (en) * | 1997-03-19 | 1998-09-19 | The Green Cross Corporation | Immunoglobulin preparation and preparation process thereof |
JP2000143536A (ja) | 1998-11-13 | 2000-05-23 | Nippon Zoki Pharmaceut Co Ltd | 抗浮腫剤 |
DE19944122A1 (de) * | 1999-09-15 | 2001-03-29 | Wolfgang Loh | Histamin-Immunglobulin-Komplexe zur Behandlung von entzündlichen Erkrankungen bei Säugetieren |
KR20070108320A (ko) * | 2006-03-20 | 2007-11-09 | 전숙영 | 알레르기질환 및 자가면역질환의 치료를 위한 약학적조성물, 그의 용도 및 알레르기질환 및 자가면역질환의치료방법 |
RU2505312C2 (ru) * | 2010-08-06 | 2014-01-27 | Олег Ильич Эпштейн | Комплексное лекарственное средство для лечения гриппа различных типов |
RU2502521C2 (ru) * | 2010-08-06 | 2013-12-27 | Олег Ильич Эпштейн | Комплексное лекарственное средство для лечения бактериальных инфекций и способ лечения бактериальных инфекций |
CN110801013B (zh) * | 2019-11-19 | 2023-03-31 | 西北农林科技大学 | 一种生物化学法制备非过敏生漆或漆酚的方法及其产品 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873697A (en) | 1972-11-11 | 1975-03-25 | Mack Chem Pharm | Histamine antigen |
RO72676A2 (ro) * | 1977-07-15 | 1982-08-17 | Institutul "Dr.Ioan Cantacuzino",Ro | Procedeu de determinare a continutului in anticorpi speciici antiamine biologic active a gamaglobulinelor |
JPS5585526A (en) * | 1978-12-23 | 1980-06-27 | Nippon Zoki Pharmaceut Co Ltd | Remedy for allergic disease |
US4704273A (en) * | 1982-05-17 | 1987-11-03 | Mcmichael John | Methods and materials for treatment of rheumatoid arthritis |
US4705685A (en) * | 1982-05-17 | 1987-11-10 | Mcmichael John | Methods and materials for treatment of disease states involving immunological factors |
JPS58225027A (ja) * | 1982-06-23 | 1983-12-27 | Fujirebio Inc | ヒスタミン加グロブリン製剤 |
US4705687A (en) | 1985-06-17 | 1987-11-10 | Ortho Pharmaceutical (Canada) Ltd. | Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor |
US5112738A (en) | 1985-07-03 | 1992-05-12 | Miles Inc. | Histamine derivatives, immunogen conjugates and antibodies raised thereto |
US5244902A (en) | 1989-08-21 | 1993-09-14 | Beth Israel Hospital Association | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses |
IT1237475B (it) | 1989-10-06 | 1993-06-07 | Allergeni modificati chimicamente e procedimento per la loro preparazione | |
US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
JP3193205B2 (ja) * | 1993-08-09 | 2001-07-30 | 日本臓器製薬株式会社 | 好酸球増多抑制剤 |
-
1995
- 1995-08-11 JP JP7227045A patent/JPH0959180A/ja not_active Withdrawn
-
1996
- 1996-08-07 TW TW085109574A patent/TW442495B/zh not_active IP Right Cessation
- 1996-08-08 US US08/694,315 patent/US6627194B1/en not_active Expired - Fee Related
- 1996-08-08 AT AT96112799T patent/ATE252603T1/de not_active IP Right Cessation
- 1996-08-08 EP EP96112799A patent/EP0758656B1/en not_active Expired - Lifetime
- 1996-08-08 KR KR1019960033064A patent/KR100436811B1/ko not_active IP Right Cessation
- 1996-08-08 DE DE69630423T patent/DE69630423T2/de not_active Expired - Fee Related
- 1996-08-09 AU AU62033/96A patent/AU713296B2/en not_active Ceased
- 1996-08-09 CA CA002183020A patent/CA2183020A1/en not_active Abandoned
- 1996-08-09 CN CN96109428A patent/CN1108818C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1108818C (zh) | 2003-05-21 |
CN1148505A (zh) | 1997-04-30 |
JPH0959180A (ja) | 1997-03-04 |
AU713296B2 (en) | 1999-11-25 |
US6627194B1 (en) | 2003-09-30 |
EP0758656B1 (en) | 2003-10-22 |
CA2183020A1 (en) | 1997-02-12 |
DE69630423D1 (de) | 2003-11-27 |
EP0758656A2 (en) | 1997-02-19 |
AU6203396A (en) | 1997-02-13 |
KR100436811B1 (ko) | 2004-08-25 |
TW442495B (en) | 2001-06-23 |
EP0758656A3 (en) | 1997-08-06 |
DE69630423T2 (de) | 2004-06-17 |
ATE252603T1 (de) | 2003-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |