KR960701000A - 안트라닐산 유도체(anthranilic acid derivative) - Google Patents

안트라닐산 유도체(anthranilic acid derivative) Download PDF

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KR960701000A
KR960701000A KR1019950703620A KR19950703620A KR960701000A KR 960701000 A KR960701000 A KR 960701000A KR 1019950703620 A KR1019950703620 A KR 1019950703620A KR 19950703620 A KR19950703620 A KR 19950703620A KR 960701000 A KR960701000 A KR 960701000A
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South Korea
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group
halogen
substituent
formula
substituted
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KR1019950703620A
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KR100189863B1 (ko
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후미히로 오자키
게이지 이시바시
히로노리 이쿠타
히로키 이시하라
시게루 소우다
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나이토 하루오
에자이 가부시키가이샤
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
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    • C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07D211/40—Oxygen atoms
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Abstract

cGMP-PDE 저해작용을 가진 안트라닐산 유도체를 제공한다.
일반식(Ⅰ)
[식중, R1, R2, R3및 R4는 동일 또는 상이한 수소원자, 할로겐원자, 수산기, 할로겐 치환되어 있어도 좋은 저급알킬기, 할로겐치환되어 있어도 좋은 저급알콕시기, 니트로기, 히드록시알킬기, 시아노기 등을 의미하며, R5, R6은 동일 또는 상이한 수소원자, 할로겐원자, 수산기, 시아노기, 할로겐치환되어 있어도 좋은 저급알킬기, 할로겐 치환되어 있어도 좋은 저급알콕시기 등을 의미한다. W는 식 -N=으로 표시되는 기 또는 식 -CH=로 표시되는 기를 의미한다. R7, R8은 동일 또는 상이한 수소원자, 할로겐치환되어 있어도 좋은 저급알킬기 등을 의미한다. A는 수소원자, 할로겐치환되어 있어도 좋은 저급알킬기 등을 의미한다. Z는 수산기, 할로겐치환되어 있어도 좋은 저급알콕시기, 시아노기, 할로겐원자 등을 의미한다. Y는 산소원자 또는 황원자를 의미한다. n은 0 또는 1~6의 정수를 의미한다.]으로 표시되는 안트라닐산 유도체 또는 그 약리학적으로 허용될수 있는 염.

Description

안트라닐산 유도체(ANTHRANILIC ACID DERIVATIVE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(I)
    [식중, R1, R2, R3및 R4는 동일 또는 상이한 수소원자, 할로겐원자, 수산기, 할로겐 치환되어 있어도 좋은 저급알킬기, 할로겐치환되어 있어도 좋은 저급알콕시기, 니트로기, 히드록시알킬기, 시아노기, 식(식중 R9, R10은 동일 또는 상이한 수소원자, 할로겐치환되어 있어도 좋은 저급알킬기, 아릴알킬기, 헤테로아릴 일킬기, 아실기, 보호되어 있어도 좋은 카르복실기를 의미한다. 또 R9, R10은 그들이 결합하고 있는 질소원자와 함께 고리를 형성하고 있어도 좋다. 더욱, 이 고리는 치환기를 갖고 있어도 좋다. p는 0 또는 1~6의 정수를 의미한다)로 표시되는 기, 치환기를 갖고 있어도 좋은 테트라졸일기, 보호되어 있어도 좋은 카르복실기, 치환기를 갖고 있어도 좋은 카르바모일기, 치환기를 갖고 있어도 좋은 피라조일기, 치환기를 갖고 있어도 좋은 이미다졸일기, 식(식중 R13은 수소 원자 또는 할로겐치환되어 있어도 좋은 저급일킬기를 의미한다. q는 0 또는 1~2의 정수를 의미한다.)로 표시되는 기를 의미한다. 더욱, R1, R2, R3, R4로부터 선택되는 서로 이웃한 2개의 치환기는 그들이 결합하고 있는 탄소원자와 함께 고리를 형성하고 있어도 좋다. R5, R6은 동일 또는 상이한 수소원자, 할로겐원자, 수산기, 시아노기, 할로겐치환되어 있어도 좋은 저급알킬기, 할로겐치환되어 있어도 좋은 저급알콕시기를 의미한다. 더욱, R5, R6은 그들이 결합하고 있는 탄소원자와 함께 시클로알킬고리, 옥솔란고리, 1, 3-디옥솔란고리, 1, 4-디옥산고리를 형성할 수 있다. W는 식 -N=으로 표시되는 기 또는 식 -CH=로 표시되는 기를 의미한다. R7, R8은 동일 또는 상이한 수소원자, 할로겐치환되어 있어도 좋은 저급알킬기를 의미한다. 더욱, R1, R7이, 각각 결합하고 있는 탄소원자와 함께, 그외에 질소원자, 산소원자, 또는 황원자를 포함하고 있어도 좋은 고리를 형성하고 있어도 좋다. 더욱이 고리는 치환기를 갖고 있어도 좋다. A는 수소원자, 할로겐치환되어 있어도 좋은 저급알킬기, 또는 식 -X-(CH2)m-Z(식중 X는 식 -CO-로 표시되는 기, 식 -CS-로 표시되는 기, 식 -CH2-로 표시되는 기 또는 식 -S(O)2-로 표시되는 기를 의미한다. Z는 수산기, 할로겐치환되어 있어도 좋은 저급알콕시기, 시아노기, 할로겐원자, 보호되어 있어도 좋은 카르바모일기, 치환기 갖고 있어도 좋은 아릴기, 치환기를 갖고 있어도 좋은 아릴옥시기, 치환기를 갖고 있어도 좋은 헤테로아릴기, 치환기를 갖고 있어도 좋은 헤테로아릴알킬옥시기, 식-NR11R12(식중 R11, R12는 동일 또는 상이한 수소원자, 할로겐치환되어 있어도 좋은 저급알킬기, 치환기를 갖고 있어도 좋은 아릴알킬기, 치환기를 갖고 있어도 좋은 헤테로아릴알킬기, 아실기, 보호되어 있어도 좋ㅇㄴ 카르복실기, 치환기를 갖고 있어도 좋은 카르바모일기를 의미한다. 또 R11과 R12는 그들이 결합하고 있는 질소원자와 함께 고리를 형성하고 있어도 좋다. 더욱 이 고리는 치환기를 갖고 있어도 좋다.)로 표시되는 기, 치환기를 갖고 있어도 좋은 시클로알킬기를 의미한다. m은 0 또는 1~6의 정수를 의미한다.)로 표시되는 기를 의미한다. Y는 산소원자 또는 황원자를 의미한다. n은 0 또는 1~6의 정수를 의미한다.]으로 표시되는 안트라닐산 유도체 또는 그 약리학적으로 허용될 수 있는 염.
  2. 일반식(II)
    (식중, R1, R2, R3, R4는 상기의 의미를 갖는다. R14는 수소원자, 할로겐 치환되어 있어도 좋은 저급알킬기, 치환기를 갖고 있어도 좋은 아릴알킬기를 의미한다. R15는 니트로기 또는 아미노기를 의미한다.)으로 표시되는 화합물 및 약리학적으로 허용될 수 있는 염.
  3. 일반식(III)
    (식중, R1, R2, R3, R4, R8, R14및 A는 상기의 의미를 갖는다)으로 표시되는 화합물 또는 그 약리학적으로 허용될 수 있는 염.
  4. 일반식(IV)
    (식중, R1, R2, R3, R4, m 및 Z는 상기의 의미를 갖는다.X2는 식 -CH2-로 표시되는 기를 의미한다.)으로 표시되는 화합물 또는 그 약리학적으로 허용될 수 있는 염.
  5. 제1항에 있어서, Y가 산소원자인 안트라니란 유도체 또는 그 약리학적으로 허용될수 있는 염.
  6. 제1항에 기재된 안트라닐산 유도체 또는 그 약리학적으로 허용될 수 있는 염을 유효성분으로 하는 포스포디에스테라제 저해작용이 유효한 질환의 예방ㆍ치료제
  7. 제1항에 기재된 안트라닐산 유도체 또는 그 약리학적으로 허용될 수 있는 염을 유효성분으로 하는 사이클릭-GMP 또는 포스포디에스테라제 저해작용이 유효한 지로한의 예방ㆍ치료제
  8. 제7항에 있어서, 질환이 허혈성 심질환, 협심증, 고혈압증, 폐고혈압증, 심부전 또는 천식인 예방ㆍ치료제.
  9. 약리학적으로 유효한 양의 제1항에 기재된 안트라닐산 유도체 또는 그 약리학적으로 허용될 수 있는 염과 약리학적으로 허용될 수 있는 담체를 함유한는 의약 조성물.
  10. 약리학적으로 유효한 양의 재1항에 기대된 안트라닐산 유도체 또는 그 약리적으로 허용될 수 있는 염을 투여하여, 그 포스포디에스테라제 저해작용은 행함으로써 질환을 예방ㆍ치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950703620A 1993-12-27 1994-12-27 안트라닐산 유도체 KR100189863B1 (ko)

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Publication number Priority date Publication date Assignee Title
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US6583157B2 (en) 1998-01-29 2003-06-24 Tularik Inc. Quinolinyl and benzothiazolyl modulators
WO1999038845A1 (en) 1998-01-29 1999-08-05 Tularik Inc. Ppar-gamma modulators
JP2001508811A (ja) * 1998-04-20 2001-07-03 藤沢薬品工業株式会社 ｃＧＭＰ−ホスホジエステラーゼ阻害剤としてのアントラニル酸誘導体
UA71587C2 (uk) * 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
CN1374953A (zh) 1999-09-16 2002-10-16 田边制药株式会社 含氮的6－员芳香环化合物
AUPQ365299A0 (en) * 1999-10-25 1999-11-18 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives
US20080027037A1 (en) * 2000-04-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Cyclic compounds
US7273868B2 (en) * 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
CN1657523A (zh) * 2000-04-28 2005-08-24 田边制药株式会社 环状化合物
US6653332B2 (en) 2000-05-03 2003-11-25 Tularik Inc. Combination therapeutic compositions and method of use
DE10023484A1 (de) * 2000-05-09 2001-11-22 Schering Ag Anthranylamide und deren Verwendung als Arzneimittel
US20030171399A1 (en) * 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
US6576644B2 (en) * 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
MXPA03007623A (es) * 2001-02-26 2003-12-04 Tanabe Seiyaku Co Derivado de piridopirimidina o naftiridina.
US6642244B2 (en) 2001-03-16 2003-11-04 Bristol-Myers Squibb Co. Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase
AU2002257195A1 (en) 2001-04-23 2002-11-05 University Of Virginia Patent Foundation Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic agents
DE10121003A1 (de) 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US20040254185A1 (en) * 2001-05-08 2004-12-16 Alexander Ernst Selective anthranilamide pyridine amides as inhibitors of vegfr-2 and vegfr-3
DE10128331A1 (de) 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
CN1551866A (zh) * 2001-08-09 2004-12-01 СҰҩƷ��ҵ��ʽ���� 羧酸衍生物化合物及包含这些化合物为活性成分的药物
US7119120B2 (en) * 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors
US7615565B2 (en) * 2002-07-31 2009-11-10 Bayer Schering Pharma Aktiengesellschaft VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
AU2003288899B2 (en) 2002-08-23 2009-09-03 Novartis Vaccines And Diagnostics, Inc. Benzimidazole quinolinones and uses thereof
KR20050106421A (ko) * 2003-02-07 2005-11-09 오노 야꾸힝 고교 가부시키가이샤 카르복실산 화합물
US7202260B2 (en) * 2003-06-13 2007-04-10 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US7223761B2 (en) * 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
JP4890255B2 (ja) 2003-11-07 2012-03-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 改良された薬物特性を有するキノリノン化合物の薬学的に受容可能な塩
DE102004009931A1 (de) * 2004-02-26 2005-09-15 Aventis Pharma Deutschland Gmbh Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz
AU2005221140A1 (en) * 2004-03-08 2005-09-22 Amgen Inc. Therapeutic modulation of PPAR (gamma) activity
WO2005107739A1 (en) * 2004-05-11 2005-11-17 Darley Pharmaceuticals Ltd. Spiroderivatives for the treatment of hypertension
EP1655295A1 (en) * 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
US7906533B2 (en) * 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
EP1657241A1 (en) 2004-11-03 2006-05-17 Schering Aktiengesellschaft Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ES2576643T3 (es) 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
AU2008304231A1 (en) * 2007-09-27 2009-04-02 Albany Molecular Research, Inc. Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US9101616B2 (en) * 2009-05-29 2015-08-11 Raqualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
HUE028977T2 (en) 2010-09-10 2017-02-28 Epizyme Inc A method for determining the suitability of human EZH2 inhibitors during treatment
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
WO2012118812A2 (en) 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
CN107365263A (zh) * 2011-07-08 2017-11-21 拜耳知识产权有限责任公司 制备2‑氨基‑5‑氰基‑n,3‑二甲基苯甲酰胺的方法
DK3628670T3 (da) 2012-04-13 2022-12-05 Epizyme Inc Saltform til ezh2-hæmning
CN110041250A (zh) 2012-10-15 2019-07-23 Epizyme股份有限公司 经取代的苯化合物
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
MX2016004703A (es) 2013-10-16 2017-02-28 Epizyme Inc Forma salina de hidrocloruro para la inhibicion de ezh2.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632153A (ko) *
JPS5095285A (ko) * 1973-12-26 1975-07-29
US4029815A (en) * 1975-04-30 1977-06-14 Schering Corporation Anti-diarrheal anthranilic acids
DE3116205A1 (de) * 1981-04-23 1982-12-30 Bayer Ag, 5090 Leverkusen 5-(2,6-dichlor-4-trifluormethyl-phenoxy)-2-nitrobenzoesaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide und pflanzenwachstumsregulatoren
JPS62242675A (ja) * 1986-04-16 1987-10-23 Hokuriku Seiyaku Co Ltd ピペラジンアセトアミド誘導体
US4897478A (en) * 1987-09-11 1990-01-30 Basf Aktiengesellschaft Preparation of haloisatoic anhydrides
GB8827988D0 (en) * 1988-11-30 1989-01-05 Smith Kline French Lab Chemical compounds

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DE69418704D1 (de) 1999-07-01
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US5716993A (en) 1998-02-10
EP0686625A1 (en) 1995-12-13
WO1995018097A1 (fr) 1995-07-06
CA2155662A1 (en) 1995-07-06
HUT74450A (en) 1996-12-30
HU9502512D0 (en) 1995-11-28
AU1282495A (en) 1995-07-17
AU694465B2 (en) 1998-07-23
NZ277556A (en) 1997-06-24
CN1118595A (zh) 1996-03-13
FI953968A0 (fi) 1995-08-23
FI953968A (fi) 1995-10-19
DE69418704T2 (de) 1999-11-25
EP0686625A4 (en) 1996-05-01
NO953305D0 (no) 1995-08-23
EP0686625B1 (en) 1999-05-26

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