KR960034171A - 버들송이(Agrocybe cylindracea)로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조 방법 - Google Patents
버들송이(Agrocybe cylindracea)로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조 방법 Download PDFInfo
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- KR960034171A KR960034171A KR1019950005095A KR19950005095A KR960034171A KR 960034171 A KR960034171 A KR 960034171A KR 1019950005095 A KR1019950005095 A KR 1019950005095A KR 19950005095 A KR19950005095 A KR 19950005095A KR 960034171 A KR960034171 A KR 960034171A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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Abstract
본 발명은 버섯류의 일종인 버들송이(Agrocybe cylindracea)로부터 생산되고 타이로시네이즈 활성 및 멜라진 생선 저해활성을 나타내는 하기 구조식(Ⅰ)의 화합물 Geri-ME006, 버들송이로부터 분리 정제함을 포함하는 상기 화합물의 제조 방법 및 상기 화합물 또는 그의 유도체를 활성성분으로서 포함하는 타이로시네이즈 활성 및 멜라닌 생성저해제 조성물에 관한 것으로, Geri-ME006은 우수한 타이로시네이즈 및 멜라닌 생선 저해 활성을 나타낸다:
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 하기 구조식(Ⅰ)로 표시되는 타이로시네이즈 활성 및 멜라닌 생성저해 물질Geri-ME006, 그의 유도체 및 약학적으로 허용되는 이들의 염:
- 버들송이(Agrocybe cylindracea)를 용매로 처리하여 Geri-ME006 화합물을 추출한 후 실리카겔 컬럼 크로마토그래피 및 고압 액체 크로마토그래피로 정제하는 것을 포함하는, Geri-ME006 화합물의 제조 방법.
- 활성성분으로서 Geri-ME006 또는 이의 유도체를 유효량 포함하는 타이로시네이즈 활성 및 멜라닌 생성 저해제 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950005095A KR0145944B1 (ko) | 1995-03-13 | 1995-03-13 | 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950005095A KR0145944B1 (ko) | 1995-03-13 | 1995-03-13 | 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960034171A true KR960034171A (ko) | 1996-10-22 |
KR0145944B1 KR0145944B1 (ko) | 1998-08-17 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019950005095A KR0145944B1 (ko) | 1995-03-13 | 1995-03-13 | 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법 |
Country Status (1)
Country | Link |
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KR (1) | KR0145944B1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101138811B1 (ko) * | 2009-04-28 | 2012-05-10 | 한불화장품주식회사 | 버들송이 추출물을 함유하는 피부 외용제 조성물 |
-
1995
- 1995-03-13 KR KR1019950005095A patent/KR0145944B1/ko not_active IP Right Cessation
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Publication number | Publication date |
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KR0145944B1 (ko) | 1998-08-17 |
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