KR960034171A - 버들송이(Agrocybe cylindracea)로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조 방법 - Google Patents

버들송이(Agrocybe cylindracea)로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조 방법 Download PDF

Info

Publication number
KR960034171A
KR960034171A KR1019950005095A KR19950005095A KR960034171A KR 960034171 A KR960034171 A KR 960034171A KR 1019950005095 A KR1019950005095 A KR 1019950005095A KR 19950005095 A KR19950005095 A KR 19950005095A KR 960034171 A KR960034171 A KR 960034171A
Authority
KR
South Korea
Prior art keywords
geri
preparing
compound
agrocybe cylindracea
methods
Prior art date
Application number
KR1019950005095A
Other languages
English (en)
Other versions
KR0145944B1 (ko
Inventor
유익동
이인경
이충환
김종평
김원곤
고영희
Original Assignee
김은영
한국과학기술연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김은영, 한국과학기술연구원 filed Critical 김은영
Priority to KR1019950005095A priority Critical patent/KR0145944B1/ko
Publication of KR960034171A publication Critical patent/KR960034171A/ko
Application granted granted Critical
Publication of KR0145944B1 publication Critical patent/KR0145944B1/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 버섯류의 일종인 버들송이(Agrocybe cylindracea)로부터 생산되고 타이로시네이즈 활성 및 멜라진 생선 저해활성을 나타내는 하기 구조식(Ⅰ)의 화합물 Geri-ME006, 버들송이로부터 분리 정제함을 포함하는 상기 화합물의 제조 방법 및 상기 화합물 또는 그의 유도체를 활성성분으로서 포함하는 타이로시네이즈 활성 및 멜라닌 생성저해제 조성물에 관한 것으로, Geri-ME006은 우수한 타이로시네이즈 및 멜라닌 생선 저해 활성을 나타낸다:

Description

버들송이(Agrocybe cylindracea)로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 구조식(Ⅰ)로 표시되는 타이로시네이즈 활성 및 멜라닌 생성저해 물질Geri-ME006, 그의 유도체 및 약학적으로 허용되는 이들의 염:
  2. 버들송이(Agrocybe cylindracea)를 용매로 처리하여 Geri-ME006 화합물을 추출한 후 실리카겔 컬럼 크로마토그래피 및 고압 액체 크로마토그래피로 정제하는 것을 포함하는, Geri-ME006 화합물의 제조 방법.
  3. 활성성분으로서 Geri-ME006 또는 이의 유도체를 유효량 포함하는 타이로시네이즈 활성 및 멜라닌 생성 저해제 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950005095A 1995-03-13 1995-03-13 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법 KR0145944B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950005095A KR0145944B1 (ko) 1995-03-13 1995-03-13 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950005095A KR0145944B1 (ko) 1995-03-13 1995-03-13 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법

Publications (2)

Publication Number Publication Date
KR960034171A true KR960034171A (ko) 1996-10-22
KR0145944B1 KR0145944B1 (ko) 1998-08-17

Family

ID=19409666

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950005095A KR0145944B1 (ko) 1995-03-13 1995-03-13 버들송이로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조방법

Country Status (1)

Country Link
KR (1) KR0145944B1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101138811B1 (ko) * 2009-04-28 2012-05-10 한불화장품주식회사 버들송이 추출물을 함유하는 피부 외용제 조성물

Also Published As

Publication number Publication date
KR0145944B1 (ko) 1998-08-17

Similar Documents

Publication Publication Date Title
DK1039895T3 (da) Anvendelse af 3-benzoylphenyleddikesyrer, estere eller amider til behandling af GLC1A-glaukom
ES2175084T3 (es) Uso de supresores de angiogenesis para inhibir el crecimiento del pelo.
DE69516866D1 (de) Stereochemische wortmanninderivate
MX9301536A (es) Agente para regular la condicion grasosa de la piel.
CO4920242A1 (es) Compuestos inhibidores de metalopreoteasas 1,4-heterocicli- cos, composiciones farmaceuticas que los contienen y metodos para su utilizacion
ES2158537T3 (es) Derivados de acidos ciclopropilalcanoicos.
EA200200708A1 (ru) Производные бензазола и их применение в качестве модуляторов jnk
KR950031059A (ko) 골다공증 치료용 약제학적 조성물
EA200101077A1 (ru) Композиция для профилактики или лечения слабоумия, включающая производное гидроксикоричной кислоты или экстракт растения рода angelicae, содержащий его
KR950031060A (ko) 골다공증 치료용 약제학적 조성물
MX9307644A (es) Medicamento que incluye 2-amino-6-n-propil-amino-4,5, 6, 7,-tetrahidrobenzotiazol con efecto antidepresivo.
KR910016330A (ko) 엘라스타제 억제제로서 벤즈이소티아졸리논-1-디옥사이드 유도체 및 그 조성물과 용도
ES2108129T3 (es) Nuevos derivados de pirazina, su preparacion y empleo.
ES2187738T3 (es) Derivados de flavonas, su procedimiento de preparacion y los compuestos farmaceuticos que las contienen.
DE69834271D1 (de) Steroid-3-o-sulfamat-derivate als estronsulfatase-hemmer
EA199800155A1 (ru) Новое соединение
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
KR950025035A (ko) 코지산 유도체
ES2174113T3 (es) Nuevos derivados de ((3-alcoxi-fenoxi)-etil)-dialquilamina y su utilizacion como anestesicos locales.
NO985679D0 (no) Dihydrobenzopyran og beslektede forbindelser nyttige som anti-inflammasjonsmidler
KR920009388A (ko) 니클로사미드를 함유하는 국소적용 침투방지 로션
KR960034171A (ko) 버들송이(Agrocybe cylindracea)로부터 생산되는 타이로시네이즈 저해 물질 및 이의 제조 방법
KR960017649A (ko) 아미노사이클로펜탄 유도체
PT880520E (pt) Derivados da benzo¬c|quinolizina sua preparacao e uso como inibidores da 5-alfa-reductase
FI951378A (fi) N-asetyyli-neuramiinihapon johdannaisten synteesi

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030507

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee