KR960014794B1 - Cardiotonic alkanoyl and aroyl oxazolones - Google Patents

Cardiotonic alkanoyl and aroyl oxazolones Download PDF

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Publication number
KR960014794B1
KR960014794B1 KR89001825A KR890001825A KR960014794B1 KR 960014794 B1 KR960014794 B1 KR 960014794B1 KR 89001825 A KR89001825 A KR 89001825A KR 890001825 A KR890001825 A KR 890001825A KR 960014794 B1 KR960014794 B1 KR 960014794B1
Authority
KR
South Korea
Prior art keywords
oxazolones
aroyl
alkanoyl
cardiotonic
cardiotonics
Prior art date
Application number
KR89001825A
Other languages
English (en)
Other versions
KR890012983A (ko
Inventor
Richard A Schnettler
Winton D Johnes
Richard C Dage
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of KR890012983A publication Critical patent/KR890012983A/ko
Application granted granted Critical
Publication of KR960014794B1 publication Critical patent/KR960014794B1/ko

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36One oxygen atom
    • C07D263/38One oxygen atom attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR89001825A 1988-02-18 1989-02-17 Cardiotonic alkanoyl and aroyl oxazolones KR960014794B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/157,430 US4866182A (en) 1988-02-18 1988-02-18 Cardiotonic alkanoyl and aroyl oxazolones
US157430 1988-02-18

Publications (2)

Publication Number Publication Date
KR890012983A KR890012983A (ko) 1989-09-20
KR960014794B1 true KR960014794B1 (en) 1996-10-19

Family

ID=22563682

Family Applications (1)

Application Number Title Priority Date Filing Date
KR89001825A KR960014794B1 (en) 1988-02-18 1989-02-17 Cardiotonic alkanoyl and aroyl oxazolones

Country Status (19)

Country Link
US (1) US4866182A (ko)
EP (1) EP0329070B1 (ko)
JP (1) JP2811577B2 (ko)
KR (1) KR960014794B1 (ko)
CN (1) CN1022035C (ko)
AT (1) ATE99681T1 (ko)
AU (1) AU614029B2 (ko)
CA (1) CA1334201C (ko)
DE (1) DE68911944T2 (ko)
DK (1) DK74889A (ko)
ES (1) ES2061748T3 (ko)
FI (1) FI890694A (ko)
HU (1) HU206880B (ko)
IL (1) IL89302A (ko)
NO (1) NO890681L (ko)
NZ (1) NZ227977A (ko)
PH (1) PH26260A (ko)
PT (1) PT89749B (ko)
ZA (1) ZA891111B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437491A (en) * 1994-04-07 1995-08-01 Illinois Tool Works Inc. Fuel door housing
DE4429461A1 (de) * 1994-08-19 1996-02-22 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
CN102993075A (zh) * 2012-11-29 2013-03-27 江苏长青农化股份有限公司 硫脲类杀虫杀螨剂丁醚脲的合成工艺
CA2988147C (en) 2015-06-03 2023-06-13 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3514465A (en) * 1966-12-30 1970-05-26 Degussa Certain thiazolyl- and pyridinylaminoketones
US4303439A (en) * 1979-10-01 1981-12-01 Monsanto Company 2-Substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acids as safening agents
JPS59100977A (ja) * 1982-12-01 1984-06-11 Omron Tateisi Electronics Co 記録情報出力方法
EP0114263B1 (de) * 1982-12-18 1987-03-11 Hans Rinninger u. Sohn GmbH u. Co. Pflasterstein
DE3246957A1 (de) * 1982-12-18 1984-06-20 Varta Batterie Ag, 3000 Hannover Galvanisches element
US4762849A (en) * 1985-10-15 1988-08-09 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoylthiazolones
US4623651A (en) * 1985-10-15 1986-11-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones
CA1266268A (en) * 1985-10-15 1990-02-27 J. Martin Grisar Cardiotonic aroylthiazolones
US4670450A (en) * 1985-11-13 1987-06-02 Merrell Dow Pharmaceuticals Inc. Cardiotonic thiazolones
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
US4689353A (en) * 1986-02-21 1987-08-25 The Dow Chemical Company Hydroxy and amino-functional polyahls containing carbonate, urethane and/or urea moieties

Also Published As

Publication number Publication date
IL89302A0 (en) 1989-09-10
FI890694A (fi) 1989-08-19
US4866182A (en) 1989-09-12
NO890681D0 (no) 1989-02-17
IL89302A (en) 1993-02-21
CN1036761A (zh) 1989-11-01
PT89749A (pt) 1989-10-04
JPH02149571A (ja) 1990-06-08
EP0329070A1 (en) 1989-08-23
AU614029B2 (en) 1991-08-15
CN1022035C (zh) 1993-09-08
FI890694A0 (fi) 1989-02-14
HUT54148A (en) 1991-01-28
DK74889D0 (da) 1989-02-17
ES2061748T3 (es) 1994-12-16
ZA891111B (en) 1989-10-25
AU2990689A (en) 1989-08-24
CA1334201C (en) 1995-01-31
JP2811577B2 (ja) 1998-10-15
DE68911944D1 (de) 1994-02-17
HU206880B (en) 1993-01-28
DE68911944T2 (de) 1994-05-19
PH26260A (en) 1992-04-01
PT89749B (pt) 1994-03-31
EP0329070B1 (en) 1994-01-05
NZ227977A (en) 1990-10-26
ATE99681T1 (de) 1994-01-15
DK74889A (da) 1989-08-19
KR890012983A (ko) 1989-09-20
NO890681L (no) 1989-08-21

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A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
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