KR950703522A - 벤젠설폰아미드유도체 및 그 용도 - Google Patents
벤젠설폰아미드유도체 및 그 용도 Download PDFInfo
- Publication number
- KR950703522A KR950703522A KR1019950701243A KR19950701243A KR950703522A KR 950703522 A KR950703522 A KR 950703522A KR 1019950701243 A KR1019950701243 A KR 1019950701243A KR 19950701243 A KR19950701243 A KR 19950701243A KR 950703522 A KR950703522 A KR 950703522A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl group
- group
- phenyl
- hydrogen atom
- butyric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000008331 benzenesulfonamides Chemical class 0.000 title claims abstract 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims abstract 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 9
- 125000005843 halogen group Chemical group 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 8
- -1 1-adamantyl group Chemical group 0.000 claims abstract 6
- 125000001424 substituent group Chemical group 0.000 claims abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 5
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 5
- 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 claims abstract 2
- 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 claims abstract 2
- 239000000043 antiallergic agent Substances 0.000 claims abstract 2
- 239000003146 anticoagulant agent Substances 0.000 claims abstract 2
- 229940127218 antiplatelet drug Drugs 0.000 claims abstract 2
- 229960004676 antithrombotic agent Drugs 0.000 claims abstract 2
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims abstract 2
- 150000001555 benzenes Chemical group 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- OMSGKCWJFNDKIQ-UHFFFAOYSA-N 4-[4-[1-[(4-bromophenyl)sulfonylamino]-2-phenylethyl]phenyl]butanoic acid Chemical compound C1=CC(CCCC(=O)O)=CC=C1C(NS(=O)(=O)C=1C=CC(Br)=CC=1)CC1=CC=CC=C1 OMSGKCWJFNDKIQ-UHFFFAOYSA-N 0.000 claims 1
- ZBNKIQPDBFRNDS-UHFFFAOYSA-N 4-[4-[1-[(4-bromophenyl)sulfonylamino]hexyl]phenyl]butanoic acid Chemical compound C=1C=C(CCCC(O)=O)C=CC=1C(CCCCC)NS(=O)(=O)C1=CC=C(Br)C=C1 ZBNKIQPDBFRNDS-UHFFFAOYSA-N 0.000 claims 1
- XWJIOOXFEUYPIG-UHFFFAOYSA-N 4-[4-[1-[(4-chlorophenyl)sulfonylamino]-2-(3-fluorophenyl)ethyl]phenyl]butanoic acid Chemical compound C1=CC(CCCC(=O)O)=CC=C1C(NS(=O)(=O)C=1C=CC(Cl)=CC=1)CC1=CC=CC(F)=C1 XWJIOOXFEUYPIG-UHFFFAOYSA-N 0.000 claims 1
- DDJWXIGSFZKOTD-UHFFFAOYSA-N 4-[4-[1-[(4-chlorophenyl)sulfonylamino]-2-phenylethyl]phenyl]butanoic acid Chemical compound C1=CC(CCCC(=O)O)=CC=C1C(NS(=O)(=O)C=1C=CC(Cl)=CC=1)CC1=CC=CC=C1 DDJWXIGSFZKOTD-UHFFFAOYSA-N 0.000 claims 1
- XOIHMEPURGXCQM-UHFFFAOYSA-N 4-[4-[1-[(4-chlorophenyl)sulfonylamino]-5-methylhexyl]phenyl]butanoic acid Chemical compound C=1C=C(CCCC(O)=O)C=CC=1C(CCCC(C)C)NS(=O)(=O)C1=CC=C(Cl)C=C1 XOIHMEPURGXCQM-UHFFFAOYSA-N 0.000 claims 1
- YZZHXFYOCJWFJO-UHFFFAOYSA-N 4-[4-[1-[(4-chlorophenyl)sulfonylamino]heptyl]phenyl]butanoic acid Chemical compound C=1C=C(CCCC(O)=O)C=CC=1C(CCCCCC)NS(=O)(=O)C1=CC=C(Cl)C=C1 YZZHXFYOCJWFJO-UHFFFAOYSA-N 0.000 claims 1
- PXVHIOUYHBXTEJ-UHFFFAOYSA-N 4-[4-[1-[(4-chlorophenyl)sulfonylamino]hexyl]phenyl]butanoic acid Chemical compound C=1C=C(CCCC(O)=O)C=CC=1C(CCCCC)NS(=O)(=O)C1=CC=C(Cl)C=C1 PXVHIOUYHBXTEJ-UHFFFAOYSA-N 0.000 claims 1
- YIVHEZUSMMCEEN-UHFFFAOYSA-N 4-[4-[1-[(4-chlorophenyl)sulfonylamino]pentyl]phenyl]butanoic acid Chemical group C=1C=C(CCCC(O)=O)C=CC=1C(CCCC)NS(=O)(=O)C1=CC=C(Cl)C=C1 YIVHEZUSMMCEEN-UHFFFAOYSA-N 0.000 claims 1
- SASMJZSVGDXINJ-UHFFFAOYSA-N 4-[4-[1-[(4-fluorophenyl)sulfonylamino]hexyl]phenyl]butanoic acid Chemical compound C=1C=C(CCCC(O)=O)C=CC=1C(CCCCC)NS(=O)(=O)C1=CC=C(F)C=C1 SASMJZSVGDXINJ-UHFFFAOYSA-N 0.000 claims 1
- HXXQEZBWKXHJDG-UHFFFAOYSA-N 4-[4-[2-(4-chlorophenyl)-1-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]butanoic acid Chemical compound C1=CC(CCCC(=O)O)=CC=C1C(NS(=O)(=O)C=1C=CC(Cl)=CC=1)CC1=CC=C(Cl)C=C1 HXXQEZBWKXHJDG-UHFFFAOYSA-N 0.000 claims 1
- 239000000924 antiasthmatic agent Substances 0.000 claims 1
- KHBQMWCZKVMBLN-IDEBNGHGSA-N benzenesulfonamide Chemical group NS(=O)(=O)[13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1 KHBQMWCZKVMBLN-IDEBNGHGSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP93-284938 | 1992-10-01 | ||
| JP28493892 | 1992-10-01 | ||
| JP93-165041 | 1993-06-11 | ||
| JP16504193 | 1993-06-11 | ||
| PCT/JP1993/001382 WO1994007848A1 (fr) | 1992-10-01 | 1993-09-29 | Derive de benzene-sulfonamide et son utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950703522A true KR950703522A (ko) | 1995-09-20 |
Family
ID=26489927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950701243A Withdrawn KR950703522A (ko) | 1992-10-01 | 1993-09-29 | 벤젠설폰아미드유도체 및 그 용도 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5597848A (enExample) |
| EP (1) | EP0663392A4 (enExample) |
| JP (1) | JPH0753505A (enExample) |
| KR (1) | KR950703522A (enExample) |
| AU (1) | AU4833993A (enExample) |
| CA (1) | CA2144780A1 (enExample) |
| TW (1) | TW245638B (enExample) |
| WO (1) | WO1994007848A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0948775A (ja) * | 1995-06-02 | 1997-02-18 | Hokuriku Seiyaku Co Ltd | （２−チエニル）アルカン酸誘導体 |
| JPH10195038A (ja) * | 1996-11-13 | 1998-07-28 | Hokuriku Seiyaku Co Ltd | ベンゼンスルホンアミド誘導体及びそれを含有する医薬 |
| JP2001509808A (ja) * | 1997-01-31 | 2001-07-24 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 多機能性カルシウム／カルモジュリン−依存性プロテインキナーゼの阻害による不整脈の処置 |
| FR2827280B1 (fr) * | 2001-07-13 | 2003-10-31 | Servier Lab | Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2005533830A (ja) * | 2002-07-09 | 2005-11-10 | ビー．エム．アール．エイ． コーポレイション ベスローテン フェンノートシャップ | トロンボキサンａ２受容体アンタゴニストおよびｃｏｘ−２阻害剤の薬剤の組み合わせ |
| JP2007508242A (ja) * | 2003-08-07 | 2007-04-05 | ビー．エム．アール．エイ． コーポレイション ベスローテン フェンノートシャップ | トロンボキサンａ２受容体アンタゴニストとシクロオキシゲネーゼ−１の阻害剤との組み合わせを伴う組成物および方法 |
| ITMI20061297A1 (it) * | 2006-07-04 | 2008-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi |
| WO2009089098A1 (en) | 2008-01-03 | 2009-07-16 | Musc Foundation For Research Development | Methods for the treatment of cancers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3535167A1 (de) * | 1985-10-02 | 1987-04-09 | Boehringer Mannheim Gmbh | Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel |
| DE3821540A1 (de) * | 1988-06-25 | 1989-12-28 | Boehringer Mannheim Gmbh | Neue sulfonamide, verfahren zu ihrer herstellung sowie solche sulfonamide enthaltende arzneimittel |
| DE3829455A1 (de) * | 1988-08-31 | 1990-03-15 | Boehringer Mannheim Gmbh | Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel |
-
1993
- 1993-09-24 JP JP5258950A patent/JPH0753505A/ja active Pending
- 1993-09-29 CA CA002144780A patent/CA2144780A1/en not_active Abandoned
- 1993-09-29 TW TW082107992A patent/TW245638B/zh active
- 1993-09-29 AU AU48339/93A patent/AU4833993A/en not_active Abandoned
- 1993-09-29 KR KR1019950701243A patent/KR950703522A/ko not_active Withdrawn
- 1993-09-29 EP EP93921078A patent/EP0663392A4/en not_active Ceased
- 1993-09-29 WO PCT/JP1993/001382 patent/WO1994007848A1/ja not_active Ceased
- 1993-09-29 US US08/397,068 patent/US5597848A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994007848A1 (fr) | 1994-04-14 |
| EP0663392A1 (en) | 1995-07-19 |
| JPH0753505A (ja) | 1995-02-28 |
| US5597848A (en) | 1997-01-28 |
| CA2144780A1 (en) | 1994-04-14 |
| TW245638B (enExample) | 1995-04-21 |
| AU4833993A (en) | 1994-04-26 |
| EP0663392A4 (en) | 1995-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19950331 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |