KR910000702A - 퀴놀론 카르복실산 유도체 - Google Patents
퀴놀론 카르복실산 유도체 Download PDFInfo
- Publication number
- KR910000702A KR910000702A KR1019890008595A KR890008595A KR910000702A KR 910000702 A KR910000702 A KR 910000702A KR 1019890008595 A KR1019890008595 A KR 1019890008595A KR 890008595 A KR890008595 A KR 890008595A KR 910000702 A KR910000702 A KR 910000702A
- Authority
- KR
- South Korea
- Prior art keywords
- amino
- carboxylic acid
- compound
- dihydro
- oxo
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 하기식의 화합물 또는 그것의 약제학적으로 허용되는 염;[식에서 R1은 C1~C4알킬이고, R2와 R3각각은 동일 또는 다르며, 수소 또는 C1~C4알킬이고, R4는 C1~C4알킬 또는 할로겐으로 임의 치환된 시클로프로필, 페닐, 할로페닐 또는 티에닐이고, 및 R5는 할로겐이다.]
- 제1항에 있어서, (+)-1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, (-)-1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, (+)-1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, (-)-1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-(2,4-디플루오로페닐)-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-티에닐-6,8-디플루오로-5-아미노-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-에톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-시클로프로필-5-아미노-8-클로로-6-플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-시클로프로필-5-아미노-8-클로로-6-플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 제1항에 있어서, 1-시클로프로필-5-아미노-6,8-디플루오로-1,4-디히드로-7-(시스-3-메틸아미노-4-메톡시-1-피롤리디닐)-4-옥소-3-퀴놀린 카르복실산인 화합물.
- 활성 성분으로서 제1항에 따른 화합물의 약물학적 유효량을 함유함을 특징으로 하는 항균 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63-152593 | 1988-06-21 | ||
JP15259388 | 1988-06-21 | ||
JP152593 | 1988-06-21 | ||
JP1058809A JPH0674261B2 (ja) | 1988-06-21 | 1989-03-10 | キノロンカルボン酸誘導体 |
JP058809 | 1989-03-10 | ||
JP89-058809 | 1989-03-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910000702A true KR910000702A (ko) | 1991-01-30 |
KR920001135B1 KR920001135B1 (ko) | 1992-02-06 |
Family
ID=26399813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890008595A KR920001135B1 (ko) | 1988-06-21 | 1989-06-21 | 퀴놀론카르복실산 유도체 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5106854A (ko) |
EP (1) | EP0347851B1 (ko) |
JP (1) | JPH0674261B2 (ko) |
KR (1) | KR920001135B1 (ko) |
AU (1) | AU617181B2 (ko) |
DE (1) | DE68910593T2 (ko) |
ES (1) | ES2061798T3 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
CN1054980A (zh) * | 1990-02-19 | 1991-10-02 | 杏林制药株式会社 | 具有旋光活性的8-甲氧基喹诺酮羧酸衍生物,它们的制备方法以及它们的中间体 |
US5342846A (en) * | 1990-12-05 | 1994-08-30 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents |
DK0911336T3 (da) * | 1996-02-27 | 2002-02-18 | Dainippon Pharmaceutical Co | Pyridoncarboxylsyrederivater og mellemprodukter til deres fremstilling |
IL132982A0 (en) * | 1997-05-21 | 2001-03-19 | Daiichi Seiyaku Co | Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives |
JPWO2003097634A1 (ja) * | 2002-05-17 | 2005-09-15 | 第一製薬株式会社 | キノロンカルボン酸誘導体の製造方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
US4822801A (en) * | 1984-07-20 | 1989-04-18 | Warner-Lambert Company | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents |
DE3509546A1 (de) * | 1985-03-16 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
US4771055A (en) * | 1986-07-28 | 1988-09-13 | Warner-Lambert Company | 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids |
DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
FR2634483B2 (fr) * | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments |
IL90062A (en) * | 1988-04-27 | 1994-10-07 | Daiichi Seiyaku Co | History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them |
DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
-
1989
- 1989-03-10 JP JP1058809A patent/JPH0674261B2/ja not_active Expired - Fee Related
- 1989-06-06 AU AU36080/89A patent/AU617181B2/en not_active Ceased
- 1989-06-20 EP EP89111229A patent/EP0347851B1/en not_active Expired - Lifetime
- 1989-06-20 ES ES89111229T patent/ES2061798T3/es not_active Expired - Lifetime
- 1989-06-20 DE DE89111229T patent/DE68910593T2/de not_active Expired - Fee Related
- 1989-06-21 KR KR1019890008595A patent/KR920001135B1/ko not_active IP Right Cessation
-
1990
- 1990-12-13 US US07/631,171 patent/US5106854A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0276875A (ja) | 1990-03-16 |
AU617181B2 (en) | 1991-11-21 |
ES2061798T3 (es) | 1994-12-16 |
JPH0674261B2 (ja) | 1994-09-21 |
DE68910593D1 (de) | 1993-12-16 |
KR920001135B1 (ko) | 1992-02-06 |
EP0347851A1 (en) | 1989-12-27 |
DE68910593T2 (de) | 1994-04-14 |
US5106854A (en) | 1992-04-21 |
AU3608089A (en) | 1990-01-04 |
EP0347851B1 (en) | 1993-11-10 |
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