KR950700233A - 아미노산 유도체 및 항활성산소제(Amino acid derivatives and anti-active oxygen agents) - Google Patents

아미노산 유도체 및 항활성산소제(Amino acid derivatives and anti-active oxygen agents)

Info

Publication number
KR950700233A
KR950700233A KR1019940702898A KR19940702898A KR950700233A KR 950700233 A KR950700233 A KR 950700233A KR 1019940702898 A KR1019940702898 A KR 1019940702898A KR 19940702898 A KR19940702898 A KR 19940702898A KR 950700233 A KR950700233 A KR 950700233A
Authority
KR
South Korea
Prior art keywords
group
amino acid
general formula
formula
side chain
Prior art date
Application number
KR1019940702898A
Other languages
English (en)
Other versions
KR100278533B1 (ko
Inventor
마나부 기타자와
게이지 이와사키
Original Assignee
도바 다다스
아지노모토가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도바 다다스, 아지노모토가부시키가이샤 filed Critical 도바 다다스
Publication of KR950700233A publication Critical patent/KR950700233A/ko
Application granted granted Critical
Publication of KR100278533B1 publication Critical patent/KR100278533B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

활성 산소 종류의 발생을 억제하고 안전성도 높으며 또한 비교적 저렴한 가격으로 제조할 수 있고, 하기 일반식(Ⅰ)의 아미노산 유도체 또는 이의 염을 유효성분으로 하는 신규한 항활성산소제에 관한 것이다.
(Ⅰ)
상기식에서, Ar은 2-하이드록시페닐기, 2-하이드록시-1-나프틸기 또는 피리딜기(여기서, 이들 기의 방향족 환에 결합된 수소원자는 1개 또는 복수개가 할로겐 원자, 알킬기, 하이드록실기, 하이드록시알킬기, 니트로기, 알콕실기 또는 카복실기에 의해 치환될 수 있다)이고, R은 아미노산의 측쇄이고, X는 -CH2-NH- 또는 -CH=N-이고, Y는 수소원자, -COOR1, -SO3H, -CON(R2)R3, -CONHCH(R5)COOR4또는 -CH2OH(여기서, R1내지 R4는 각각 수소원자 또는 알킬기이며, R5는 아미노산의 측쇄이다)이고, n은 0 또는 1의 정수이다.

Description

아미노산 유도체 및 항활성산소제(Amino acid derivatives and anti-active oxygen agents)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅰ)의 아미노산 유도체 또는 이의 염을 유효성분으로서 함유함을 특징으로 하는 항활성산소제.
    (Ⅰ)
    상기식에서, Ar은 2-하이드록시페닐기, 2-하이드록시-1-나프틸기 또는 피리딜기(여기서, 이들 기의 방향족 환에 결합된 수소원자는 1개 또는 복수개가 독립적으로 할로겐 원자, 탄소수 1 내지 6의 알킬기, 하이드록실기, 탄소수 1 내지 6의 하이드록시 알킬기, 니트로기, 탄소수 1 내지 6의 알콕실기 또는 카복실기에 의해 치환될 수 있다)이고, R은 아미노산의 측쇄이고, X는 -CH2-NH- 또는 -CH=N-이고, Y는 수소원자, -COOR1, -SO3H, -CON(R2)R3, -CONHCH(R5)COOR|4또는 -CH2OH(여기서, R1내지 R4는 각각 수소원자 또는 탄소수 1 내지 6의 알킬기이며, R5는 아미노산의 측쇄이다)이고, n은 0 또는 1의 정수이다.
  2. 하기 일반식(Ⅱ)의 아미노산 유도체.
    (Ⅱ)
    상기식에서, Ar1은 2-하이드록시페닐기(여기서, 이러한 기의 방향족 환에 결합된 수소원자는 1개 또는 복수개가 일반식(Ⅰ)에서와 동일한 할로겐 원자, 알킬기, 하이드록실기, 하이드록시알킬기, 니트로기, 알콕실기 또는 카복실기에 의해 유사하게 치환될 수 있다)이고, Ra는 발린, 로이신, 이소로이신, 글루탐산, 글루타민, 아스파라긴, 알기닌, 라이신, 메티오닌, 트레오닌, 티로신, 트립토판, 호모세린 또는 3,4-디하이드록시페닐 알라닌의 측쇄 또는 수소원자이고, X1은 -CH2-NH- 이고, Y 및 n은 일반식(Ⅰ)에서 정의한 바와 동일하다.
  3. 하기 일반식(Ⅲ)의 아미노산 유도체.
    (Ⅲ)
    상기식에서, Ar2은 2-하이드록시-1-나프틸기(여기서, 이러한 기의 방향족 환에 결합된 수소원자는 1개 또는 복수개가 일반식(Ⅰ)에서와 동일한 할로겐 원자, 알킬기, 하이드록실기, 하이드록시알킬기, 니트로기, 알콕실기 또는 카복실기에 의해 치환될 수 있다)이고, Rb는 로이신, 이소로이신, 글루탐산, 글루타민, 아스파프트산, 아스파라긴, 알기닌, 히스티딘, 라이신, 메티오닌, 시스테인, 세린, 트레오닌, 티로신, 페닐알라닌, 트립토판, 호모세린 또는 3,4-디하이드록시페닐알라닌의 측쇄이고, X2는 -CH=N-이고, Y 및 n은 각각 일반식(Ⅰ)에서 정의한 바와 동일하다.
  4. 제1항에서 청구한 일반식(Ⅰ)의 아미노산 유도체 또는 이의 염을 항활성산소성분으로서 함유함을 특징으로 하는 화장품.
  5. 제1항에서 청구한 일반식(Ⅰ)의 아미노산 유도체 또는 이의 염을 항활성산소성분으로서 함유함을 특징으로 하는 피부노화방지제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702898A 1992-12-21 1993-12-20 아미노산 유도체 및 항활성산소제 KR100278533B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP?92-340426? 1992-12-21
JP92-340426 1992-12-21
JP34042692 1992-12-21
PCT/JP1993/001842 WO1994014755A1 (en) 1992-12-21 1993-12-20 Amino acid derivative and anti-active-oxygen agent

Publications (2)

Publication Number Publication Date
KR950700233A true KR950700233A (ko) 1995-01-16
KR100278533B1 KR100278533B1 (ko) 2001-01-15

Family

ID=18336847

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702898A KR100278533B1 (ko) 1992-12-21 1993-12-20 아미노산 유도체 및 항활성산소제

Country Status (8)

Country Link
US (1) US5594012A (ko)
EP (1) EP0629606B1 (ko)
JP (1) JP3318930B2 (ko)
KR (1) KR100278533B1 (ko)
DE (1) DE69321583T2 (ko)
ES (1) ES2123119T3 (ko)
TW (1) TW268936B (ko)
WO (1) WO1994014755A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585391A (en) * 1993-10-08 1996-12-17 Fhj Scientific, Inc. Hydroxyl ions as unique therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents and processes for preparing them
US5679711A (en) * 1993-10-08 1997-10-21 Fhj Scientific, Inc. Hydroxyl ions as novel therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents
JP3906514B2 (ja) * 1997-04-03 2007-04-18 味の素株式会社 アミノ酸誘導体及び抗活性酸素剤
FR2775973B1 (fr) * 1998-03-13 2000-06-23 Oreal Nouveaux derives d'histidine, procede de preparation et utilisations
TW544310B (en) 1998-04-02 2003-08-01 Ajinomoto Kk Amino acid derivatives and anti-inflammatory agents
WO1999052501A1 (en) * 1998-04-16 1999-10-21 The Procter & Gamble Company Skin care compositions comprising a hydrophobic metal ion chelator
JP2008007442A (ja) 2006-06-28 2008-01-17 Univ Kanagawa 化粧料
US7704521B2 (en) * 2007-04-11 2010-04-27 Zinpro Corporation Rumen protected essential amino acids
JPWO2010032489A1 (ja) 2008-09-22 2012-02-09 国立大学法人旭川医科大学 鉄キレート剤及びその製造方法、並びに鉄イオンの定量・捕捉方法
US20230107812A1 (en) * 2021-01-26 2023-04-06 Renovel Innovations, Inc Halogenated benzylidine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE266189C (ko) *
FR2524877A1 (fr) * 1982-04-07 1983-10-14 Human Pharm Sa Laboratoires Procede nouveau de production de l'aspartame
JPS60222416A (ja) * 1984-04-17 1985-11-07 Sogo Yatsukou Kk 皮膚用剤
JPS61215306A (ja) * 1985-03-19 1986-09-25 Nippon Kanko Shikiso Kenkyusho:Kk 新規美白剤
US4792355A (en) * 1987-01-20 1988-12-20 Ford Motor Company Corrosion inhibiting aqueous, acidic compositions comprising metal-chelating omicron-hydroxybenzylamine compound
DD266189A1 (de) * 1987-09-28 1989-03-22 Wolfen Filmfab Veb Stabiler farbentwickler

Also Published As

Publication number Publication date
EP0629606A1 (en) 1994-12-21
US5594012A (en) 1997-01-14
WO1994014755A1 (en) 1994-07-07
DE69321583D1 (de) 1998-11-19
ES2123119T3 (es) 1999-01-01
TW268936B (ko) 1996-01-21
DE69321583T2 (de) 1999-06-24
EP0629606A4 (en) 1995-08-09
JP3318930B2 (ja) 2002-08-26
EP0629606B1 (en) 1998-10-14
KR100278533B1 (ko) 2001-01-15

Similar Documents

Publication Publication Date Title
KR950700233A (ko) 아미노산 유도체 및 항활성산소제(Amino acid derivatives and anti-active oxygen agents)
ES2082805T3 (es) Derivados de tiazol, procedimientos para su produccion y composiciones farmaceuticas que comprenden los mismos.
KR940005261A (ko) 피부외용제
LU91587I2 (fr) Agomélatine et ses dérivés pharmaceutiquement acceptables (VALDOXAN)
PT98358A (pt) Processo para a preparacao de novos compostos pirazolopiridinicos
AU534233B2 (en) Muramyldipeptide derivatives
ES2132676T3 (es) Composiciones de peroxigeno.
KR910000631A (ko) 디-3급-부틸(히드록시)페닐 티오 치환된 히드록삼산 유도체
KR950029244A (ko) 신규한 폴리엔계 화합물, 그를 함유하는 약제학 및 미용상의 조성물 및 용도
ES2172093T3 (es) Nuevas composiciones cosmeticas que comprenden un polimero filmogeno.
DE69233743D1 (de) Antivirale Mittel enthaltend Phenylessigsäurederivate
SE7601207L (sv) Acetylenderivat av acetyleniska aminosyror
ES552593A0 (es) Un procedimiento para preparar derivados de aminoacidos
KR890000407A (ko) 신규 "벤조일아미노페녹시부탄산 유도체" 및 그의 제조방법
ES2037665T3 (es) Procedimiento para la preparacion de compuestos heterociclicos que contienen n.
ES8404360A1 (es) Un procedimiento para preparar compuestos de cefem.
ES505672A0 (es) Procedimiento para la preparacion de oximas de acidos piru- vicos
KR890701545A (ko) 건선치료를 위한 제약학적 조성물
DK601683D0 (da) Dialkylaminoalkoxybenzylalkoholderivater
KR930017885A (ko) 항종양 조성물 및 종양의 치료방법
ES547306A0 (es) Procedimiento para la produccion de derivados de quinolina.
KR880002822A (ko) 뇌허혈증 예방 치료제
KR900003177A (ko) 테트라시클릭계 우울증 치료제
RS50423B (sr) Novi derivati oktahidro-6,10-diokso-6h-piridazino(1,2-a) (1,2) diazepin-1-karboksilne kiseline, njihov postupak dobijanja i njihova primena za dobijanje farmaceutski aktivnih jedinjenja
KR890011835A (ko) 시스테인 유도체

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20121002

Year of fee payment: 13

FPAY Annual fee payment

Payment date: 20131001

Year of fee payment: 14

EXPY Expiration of term