KR910000631A - 디-3급-부틸(히드록시)페닐 티오 치환된 히드록삼산 유도체 - Google Patents

디-3급-부틸(히드록시)페닐 티오 치환된 히드록삼산 유도체 Download PDF

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KR910000631A
KR910000631A KR1019900009767A KR900009767A KR910000631A KR 910000631 A KR910000631 A KR 910000631A KR 1019900009767 A KR1019900009767 A KR 1019900009767A KR 900009767 A KR900009767 A KR 900009767A KR 910000631 A KR910000631 A KR 910000631A
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compound
tert
butyl
branched
straight
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KR1019900009767A
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사이찌 마쓰모또
다꾸지 미즈이
마사미 도떼우찌
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요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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Publication of KR910000631A publication Critical patent/KR910000631A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

디-3급-부틸(히드록시) 페닐 티오 치환된 히드록삼산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용되는 그의 염.
    [식에서, X는 페닐렌을 통해 Y에 부착될 수도 있는 직쇄 또는 측쇄의 C1내지 C15알킬렌이고, 단 X는 n-부틸메틸렌이 아니고: Y는 CO-N(OH)이고: 및 R은 수소, 직쇄 또는 측쇄의 C1내지 C9알킬, C3내지 C9시클로알킬, 아릴 또는 아릴킬이고, 단 Y-R이 N(OH)-CO-R 일대 R은 수소가 아니다.]
  2. 제1항에 있어서, X가 직쇄 또는 측쇄의 C1내지 C15알킬렌의 화합물.
  3. 제1항 내지 2항에 있어서, m이 n-펜타메틸렌인 화합물.
  4. 제1항에 있어서, N-메틸-6-(3,5-디-3급-부틸-4-히드록시페닐티오)카프로 히드록삼인 화합물.
  5. (1) 하기 일반식(Ⅲ)의 카르복실산 유도체와 하기 일반식(Ⅳ)의 히드록실 아민과의 반응:
    [식에서 X 및 Y, R 각각은 전기 동일한 의미를 갖고 있고 Z는 이탈기임.]
    (2) 2,6-디-3급-부틸-4-메르캅토 페놀과 일반식(Ⅴ)의 화합물과의 반응
    Hal-X-Y-R
    [식에서, X, Y 및 R 각각은 전기 정의된 바와 동일하고 Hal은 할로겐임]또는, (3) 일반식(Ⅳ)의 O, N-디아실 유도체의 가수분해:
    [식에서, X 및 R 각각은 전기 정의된 바와 동일하다.]중의 어느 한 반응임을 특징으로 하는 하기 일반식(Ⅱ) 또는 약제학적으로 허용되는 그의 염을 제조하는 방법.
    [식에서, X, Y 및 R은 전기 정의된 바와 동일하다.]
  6. 유효성분으로서 제1항에 따른 화합물을, 약제학적으로 허용 가능하고 실제적으로 비독성인 담체 또는 부형제와 함께 함유하는 약제학적 조성물.
  7. 제1항에 따른 화합물을 적어도 1종을 약물학적 유효량으로 함유하는, 포유류의 아테롬성 동맥 경화증의 치료에 사용되는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900009767A 1989-06-29 1990-06-29 디-3급-부틸(히드록시)페닐 티오 치환된 히드록삼산 유도체 KR910000631A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16749789 1989-06-29
JP1-167497 1989-06-29

Publications (1)

Publication Number Publication Date
KR910000631A true KR910000631A (ko) 1991-01-29

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ID=15850778

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KR1019900009767A KR910000631A (ko) 1989-06-29 1990-06-29 디-3급-부틸(히드록시)페닐 티오 치환된 히드록삼산 유도체

Country Status (8)

Country Link
US (1) US5091569A (ko)
EP (1) EP0405788B1 (ko)
JP (1) JP3065636B2 (ko)
KR (1) KR910000631A (ko)
AT (1) ATE102607T1 (ko)
DE (1) DE69007183T2 (ko)
DK (1) DK0405788T3 (ko)
ES (1) ES2062367T3 (ko)

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WO1992007825A1 (en) * 1990-11-05 1992-05-14 Taisho Pharmaceutical Co., Ltd. Phenol derivative
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DE69418947T2 (de) * 1993-03-10 1999-12-23 Morinaga Milk Industry Co Ltd Stilbenderivate und analoga sowie deren anwendung
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
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DK0405788T3 (da) 1994-04-11
US5091569A (en) 1992-02-25
DE69007183T2 (de) 1994-06-16
ATE102607T1 (de) 1994-03-15
EP0405788B1 (en) 1994-03-09
ES2062367T3 (es) 1994-12-16
EP0405788A2 (en) 1991-01-02
JPH0395154A (ja) 1991-04-19
EP0405788A3 (en) 1991-04-17
DE69007183D1 (de) 1994-04-14
JP3065636B2 (ja) 2000-07-17

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