KR950031038A - 폴리비닐피롤리돈과 키토산 유도체의 상호반응에 의해 형성된 겔 - Google Patents

폴리비닐피롤리돈과 키토산 유도체의 상호반응에 의해 형성된 겔 Download PDF

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KR950031038A
KR950031038A KR1019950000520A KR19950000520A KR950031038A KR 950031038 A KR950031038 A KR 950031038A KR 1019950000520 A KR1019950000520 A KR 1019950000520A KR 19950000520 A KR19950000520 A KR 19950000520A KR 950031038 A KR950031038 A KR 950031038A
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에이치. 로렌츠 도날드
씨. 리 코니
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커티스 엘, 칼.
히드로머 인코포레이티드
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Abstract

본 발명의 조성물은 적어도 60의 K값과 고리-개방된 피롤리돈으로 부터의 산기 1.4몰 당량 이상을 갖는 폴리(N-비닐락탐),과 중화된 키토산으로된 안정한 겔을 포함한다. 상기 조성물은 또한 겔과 혼합된 기재 및 다양한 첨가제를 포함할 수 있다. 겔을 만드는 방법은 수성용액중에 키토산과 폴리(N-비닐락탐)을 혼합하고, 경화시키는 것을 포함한다. 제품은 상처 패킹, 상처 드레싱, 화상 드레싱, 약제 전달 드레싱, 화장용 안면 마스크, 및 화장용 랩 드레싱을 포함한다.

Description

폴리비닐피롤리돈과 키토산 유도체이 상호반응에 의해 형성된 겔
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (31)

  1. 적어도 60의 K값 및 고리-개방된 피롤리돈 기로 부터의 1.4몰 당량이상의 이용가능한 산기를 갖는 친수성 폴리(N-비닐락탐)과 중화된 키토산의 블렌드로 구성된 친수성 겔을 포함하는 피부의학적으로-융화성인 조성물.
  2. 제1항에 있어서, 폴리(N-비닐락탐)이 폴리비닐 피롤리돈 단독 중합체 또는 삼량체를 포함하는 조성물.
  3. 제1항에 있어서, 겔이 12/1 내지 2/1의 폴리(N-비닐락탐)/키토산 중량비를 포함하는 조성물.
  4. 제1항에 있어서, 겔이 5중량% 내지 20중량%의 폴리(N-비닐락탐)과 키토산 총 중합체 농도로 수성용 액중에서 제조된 조성물.
  5. 제1항에 있어서, 용액이 물 또는 히드로알콜을 포함하는 조성물.
  6. 제1항에 있어서, 폴리(N-비닐락탐)이 적어도 2.0의 몰당량의 이용가능한 산기를 갖는 조성물.
  7. 제1항에 있어서, 적어도 하나의 기재를 추가로 포함하는 조성물.
  8. 제7항에 있어서, 기재가 중합체 막, 콜라겐 막, 직물, 및 부직포로 구성되는 그룹으로 부터 선택된 조성물.
  9. 제7항에 있어서, 기재가 폴리우레탄 막인 조성물.
  10. 제7항에 있어서, 기재가 폴리에스테르 막인 조성물.
  11. 제7항에 있어서, 기재가 신축성있는 조성물.
  12. 제7항에 있어서, 기재가 박리 라이너인 조성물.
  13. 제1항에 있어서, 겔이 적어도 하나의 추가적 성분을 포함하는 조성물.
  14. 제13항에 있어서, 추가적 성분이 계면활성제인 조성물.
  15. 제13항에 있어서, 추가적 성분이 겔로부터 방출가능한 조성물.
  16. 제15항에 있어서, 추가적 성분이 방향물질인 조성물.
  17. 제15항에 있어서, 추가적 성분이 생물학적으로-활성물질인 조성물.
  18. 제17항에 있어서, 추가적 성분이 니트로글리세린, 스코폴라민, 필로카핀, 에르고타민 타르트레이트, 페닐프로만올라민, 테오필린, 테트라사이클린, 네오마이신, 옥시테트라사이클린, 트리클로산, 나트륨 세파졸린, 은 셀파디아진, 살리실산 염, 니코틴 산염, 캡사이신 및 벤조카인으로 구성되는 그룹으로 부터 선택된 조성물.
  19. 충중합체 함량이 5중량%이상으로 폴리(N-비닐락탐)/키토산비가 12/1 내지 2/1인, 적어도 60의 K값과 1.4 몰 당량의 이용가능한 산기를 갖는 수성 분산된 폴리(N-비닐락탐) 단독중합체 또는 공중합체와 중화된 키토산의 수성용액을 혼합하여 블렌드를 생성하고, 블렌드를 겔이 형성될때까지 10초 내지 2시간 동안 경화시키는 것을 포함하는 안정한 약하게 끈적끈적한 친수성 겔을 제조하기 위한 방법.
  20. 제19항에 있어서, 50℃ 내지 200℃에서, 15psi 내지 15psi의 압력으로, 반시간 내지 10일 동안 수성용액중의 폴리(N-비닐락탐)을 가열하여 1.4이상으로 산기의 올당량을 증가시키기 위하여 폴리비닐 피롤리돈 폴리(N-비닐락탐)을 처리하는 것을 추가로 포함하는 방법.
  21. 제20항에 있어서, 수성용액이 4 내지 8의 pH를 갖는 방법.
  22. 제19항에 있어서, 생물학적으로 활성 물질을 블렌드에 첨가하는 것을 추가로 포함하는 방법.
  23. 제22항에 있어서, 생물학적으로 활성물질이 살균제인 방법.
  24. 제19항에 있어서, 블렌드가 블렌드를 기재에 코팅하거나 캐스팅(casting)하여 드레싱으로 형성되는 방법.
  25. 제24항에 있어서, 블렌드가 박리 라이너인 제2기재로 덮혀지는 방법.
  26. 제19항에 있어서, 블렌드가 겔의 두개의 별개의 슬랩(slabs)을 두개의 별개의 기재에 캐스팅하고, 생물학적 활성 물질의 용액을 슬랩들중 하나의 표면에 적용하며, 생물학적 활성 물질이 슬랩들 사이에 위치하도록 슬랩들을 함께 압축하여 드레싱으로 형성되는 방법.
  27. 제26항에 있어서, 생물학적 활성 물질이 살리실산 염, 니코틴산 염 및 캡사이신으로 구성되는 그룹으로 부터 선택된 방법.
  28. 제1항에 있어서, 상처 패킹, 상처 드레싱, 화상 드레싱, 약제 전달 드레싱, 건조 막, 화장용 마스크 드레싱 및 화장용 랩 드레싱으로 구성되는 그룹으로 부터 선택된 제품 형태인 조성물.
  29. 제28항에 있어서, 기재가 없는 상처 패킹 또는 캐비터 드레싱 형태인 조성물.
  30. 제1항에 있어서, 건조막 형태의 조성물.
  31. 적어도 60의 K값과 1.4몰 당량의 이용가능한 산기를 갖는 친수성 폴리(N-비닐락탐)과 중화된 키토산의 블렌드로 구성되고, 상기 키토산과 폴리(N-비닐락탐)이 적어도 5중량%의 총중합체 농도로 키토산/폴리(N-비닐락탐)중량비가 12/1 내지 2/1로 혼합된 안정된 친수성 겔.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950000520A 1994-01-13 1995-01-13 폴리비닐피롤리돈과키토산유도체의상호반응에의해형성된겔 KR100349020B1 (ko)

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US08/181,625 US5420197A (en) 1994-01-13 1994-01-13 Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives
US08/181625 1994-01-13

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