KR950005785A - 신규한 불소화 알킬 유도체 및 그의 제조방법 - Google Patents

신규한 불소화 알킬 유도체 및 그의 제조방법 Download PDF

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KR950005785A
KR950005785A KR1019930014927A KR930014927A KR950005785A KR 950005785 A KR950005785 A KR 950005785A KR 1019930014927 A KR1019930014927 A KR 1019930014927A KR 930014927 A KR930014927 A KR 930014927A KR 950005785 A KR950005785 A KR 950005785A
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South Korea
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group
compound
carbon atoms
general formula
alkyl
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KR1019930014927A
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KR970011010B1 (ko
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조광연
김범태
김영섭
민용기
박노균
정인화
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강박광
재단법인 한국화학연구소
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Priority to KR1019930014927A priority Critical patent/KR970011010B1/ko
Priority to US08/280,477 priority patent/US5498730A/en
Priority to JP6179198A priority patent/JP2685716B2/ja
Publication of KR950005785A publication Critical patent/KR950005785A/ko
Priority to KR1019970010127A priority patent/KR970011702B1/ko
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Publication of KR970011010B1 publication Critical patent/KR970011010B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/08—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/03—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 신규한 불소화 알킬 유도체 및 그의 제조방법에 관한 것이다. 좀 더 구체적으로, 본 발명은 하기 일반식(Ⅰ) 및 (Ⅱ)로 나타내어지는 신규한 불소화 알킬 화합물의 제조방법 및 하기 일반식(Ⅰ)의 신규한 알킬유도체 화합물에 관한 것이다.
상기식에서, R은 탄소수가 2 내지 4개인 저급알킬, 시클로헥실 및 티오펜이거나, 수소 또는 저급알킬, 할로알킬, 할로겐 및 알콕시기로 치환된 페닐기이며; 및, Rf는 불소가 치환된 탄소수가 1 내지 3개의 저급알킬기이다.
본 발명의 일반식(Ⅰ)의 화합물은 농약 및 의약의 활성성분으로 이용될 수 있으며, 또한, 유효성분을 합성하는 중간체로도 유용하다.

Description

신규한 불소화 알킬 유도체 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅰ)로 표시되는 불소화 알킬케탈 유도체.
    상기식에서, R은 탄소수가 2 내지 4개인 저급알킬, 시클로헥실 및 티오펜이거나, 수소, 탄소수가 1 내지 6개인 알킬, 할로알킬, 할로겐 및 알콕시기로 치환된 페닐기이며; 및, Rf는 불소가 치환된 탄소수가 1 내지 3개의 저급알킬기이다.
  2. 다음 일반식(Ⅲ)의 불소화 알킬케톤 화합물을 루이스 산 존재하에 티오펠과 반응시켜 다음 일반식(I)의 화합물을 제조하는 방법.
    상기 식에서, R 및 Rf는 제1항에서 정의한 바와 같다.
  3. 제 2항에 있어서, 촉매로서 염화 알루미늄, 플루오르화붕소-에틸에테르, 염화철(Ⅲ), 염화주석(Ⅳ) 및 염화티탄(Ⅳ)으로 구성된 그룹으로부터 선택된 루이스 산을 사용하는 것을 특징으로 하는 방법.
  4. 제2항에 있어서, 반응용매는 이염화메탄, 디클로로에탄 및 사염화탄소로 구성된 그룹으로부터 선택된 1종 이상을 사용하는 것을 특징으로 하는 방법.
  5. 다음 일반식(Ⅰ)이 불소화 알킬 화합물을 환원시켜 다음 일반식(Ⅱ)의 화합물을 제조하는 방법.
    상기 식에서, R 및 Rf는 제 1항에서 정의한 바와 같다.
  6. 제 5항에 있어서, 환원제로서는 라니니켈, 수소화알루미늄리튬, 수소화붕소나트륨 및 수소화삼부틸주석으로 구성된 그룹으로부터 선택되는 것을 특징으로 하는 방법.
  7. 제 5항에 있어서, 환원제로 수소화삼부틸주석을 사용하는 것을 특징으로 하는 방법.
  8. 제 5항에 있어서, 반응용매로는 에테르, 테트라히드로후란, 벤젠 및 톨루엔으로 구성된 그룹으로 선택된1종 이상을 사용하는 것을 특징으로 하는 방법.
  9. 제 5항에 있어서, 촉매로서 라디칼 개시제를 추가로 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930014927A 1993-08-02 1993-08-02 신규한 불소화 알킬 유도체 및 그의 제조방법 KR970011010B1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019930014927A KR970011010B1 (ko) 1993-08-02 1993-08-02 신규한 불소화 알킬 유도체 및 그의 제조방법
US08/280,477 US5498730A (en) 1993-08-02 1994-07-26 Fluorinated alkyl compound derivatives and process for preparing same
JP6179198A JP2685716B2 (ja) 1993-08-02 1994-07-29 新規なフッ素化アルキル誘導体及びその製造方法
KR1019970010127A KR970011702B1 (ko) 1993-08-02 1997-03-24 신규한 불소화 알킬 유도체 및 그의 제조방법

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KR1019930014927A KR970011010B1 (ko) 1993-08-02 1993-08-02 신규한 불소화 알킬 유도체 및 그의 제조방법

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KR1019970010127A Division KR970011702B1 (ko) 1993-08-02 1997-03-24 신규한 불소화 알킬 유도체 및 그의 제조방법

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KR950005785A true KR950005785A (ko) 1995-03-20
KR970011010B1 KR970011010B1 (ko) 1997-07-05

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KR1019930014927A KR970011010B1 (ko) 1993-08-02 1993-08-02 신규한 불소화 알킬 유도체 및 그의 제조방법
KR1019970010127A KR970011702B1 (ko) 1993-08-02 1997-03-24 신규한 불소화 알킬 유도체 및 그의 제조방법

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US (1) US5498730A (ko)
JP (1) JP2685716B2 (ko)
KR (2) KR970011010B1 (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011207871A (ja) * 2010-03-11 2011-10-20 Agc Seimi Chemical Co Ltd 液晶化合物、その製造方法、液晶組成物および液晶電気光学素子
JP6475524B2 (ja) * 2014-12-25 2019-02-27 公益財団法人相模中央化学研究所 （フルオロアルキル）アレーンの製造方法

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KR970011702B1 (ko) 1997-07-14
US5498730A (en) 1996-03-12
JP2685716B2 (ja) 1997-12-03
KR970011010B1 (ko) 1997-07-05
JPH0753506A (ja) 1995-02-28

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