KR940014335A - 에이즈의 치료에 유용한 에이치아이브이(hiv) 프로테아제 억제제 - Google Patents
에이즈의 치료에 유용한 에이치아이브이(hiv) 프로테아제 억제제 Download PDFInfo
- Publication number
- KR940014335A KR940014335A KR1019930029119A KR930029119A KR940014335A KR 940014335 A KR940014335 A KR 940014335A KR 1019930029119 A KR1019930029119 A KR 1019930029119A KR 930029119 A KR930029119 A KR 930029119A KR 940014335 A KR940014335 A KR 940014335A
- Authority
- KR
- South Korea
- Prior art keywords
- amino
- hydroxy
- heterocycle
- aryl
- butyl
- Prior art date
Links
- 208000030507 AIDS Diseases 0.000 title abstract 2
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- -1 (t-butyl) amino Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- ZSCCBVQXDLCJAF-UHFFFAOYSA-N C1=CC=CC2=NC(C(=O)NCCCCCC)=CC=C21 Chemical compound C1=CC=CC2=NC(C(=O)NCCCCCC)=CC=C21 ZSCCBVQXDLCJAF-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- QVFQOSQPCCDXMX-UHFFFAOYSA-N n-octylbenzamide Chemical compound CCCCCCCCNC(=O)C1=CC=CC=C1 QVFQOSQPCCDXMX-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US994,871 | 1992-12-22 | ||
| US07/994,871 US5434265A (en) | 1992-12-22 | 1992-12-22 | Inhibitors of HIV protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR940014335A true KR940014335A (ko) | 1994-07-18 |
Family
ID=25541167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930029119A KR940014335A (ko) | 1992-12-22 | 1993-12-22 | 에이즈의 치료에 유용한 에이치아이브이(hiv) 프로테아제 억제제 |
Country Status (24)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5679688A (en) | 1992-03-11 | 1997-10-21 | Narhex Limited | Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| DE4439193A1 (de) * | 1994-11-03 | 1996-05-09 | Bayer Ag | Mischung zur Korrosionshemmung von Metallen |
| US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
| US5932550A (en) * | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| KR100490807B1 (ko) * | 1995-11-28 | 2005-10-14 | 세파론, 인코포레이티드 | 시스테인및세린프로테아제의d-아미노산함유억제제 |
| KR19980703369A (ko) * | 1996-01-29 | 1998-10-15 | 후루따 다께시 | 카르보닐 화합물의 환원 방법 |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| EP0900566A4 (en) | 1996-12-27 | 2001-04-25 | Japan Energy Corp | NEW TRIPEPTIDE COMPOUNDS AND MEDICINES AGAINST AIDS |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US6096778A (en) * | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| US6150378A (en) * | 1997-10-07 | 2000-11-21 | Cephalon, Inc. | Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors |
| EP1095022A1 (en) * | 1998-07-08 | 2001-05-02 | G.D. Searle & Co. | Retroviral protease inhibitors |
| EP1954685A4 (en) * | 2005-11-16 | 2009-11-11 | Nitromed Inc | FUROXANE COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| EP0558603B1 (en) * | 1990-11-19 | 1998-08-26 | Monsanto Company | Retroviral protease inhibitors |
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| US5516784A (en) * | 1991-08-13 | 1996-05-14 | Schering Corporation | Anti-HIV (AIDS) agents |
| US5491166A (en) * | 1992-12-22 | 1996-02-13 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
-
1992
- 1992-12-22 US US07/994,871 patent/US5434265A/en not_active Expired - Fee Related
-
1993
- 1993-12-15 MX MX9308005A patent/MX9308005A/es not_active IP Right Cessation
- 1993-12-17 NZ NZ250492A patent/NZ250492A/en unknown
- 1993-12-17 ZA ZA939476A patent/ZA939476B/xx unknown
- 1993-12-17 CZ CZ932816A patent/CZ281693A3/cs unknown
- 1993-12-20 PL PL93301576A patent/PL301576A1/xx unknown
- 1993-12-20 ES ES93310357T patent/ES2101252T3/es not_active Expired - Lifetime
- 1993-12-20 DE DE69308514T patent/DE69308514T2/de not_active Expired - Fee Related
- 1993-12-20 NO NO934718A patent/NO301005B1/no unknown
- 1993-12-20 YU YU79693A patent/YU79693A/sh unknown
- 1993-12-20 DK DK93310357.4T patent/DK0604183T3/da active
- 1993-12-20 AT AT93310357T patent/ATE149488T1/de active
- 1993-12-20 EP EP93310357A patent/EP0604183B1/en not_active Expired - Lifetime
- 1993-12-20 IL IL108091A patent/IL108091A/en not_active IP Right Cessation
- 1993-12-20 HU HU9303680A patent/HUT70748A/hu unknown
- 1993-12-20 AU AU52530/93A patent/AU667593B2/en not_active Ceased
- 1993-12-21 CA CA002112041A patent/CA2112041A1/en not_active Abandoned
- 1993-12-21 CN CN93112961A patent/CN1098407A/zh active Pending
- 1993-12-21 BR BR9305164A patent/BR9305164A/pt not_active Application Discontinuation
- 1993-12-21 FI FI935777A patent/FI935777A/fi not_active Application Discontinuation
- 1993-12-21 JP JP5321988A patent/JPH07179417A/ja active Pending
- 1993-12-22 KR KR1019930029119A patent/KR940014335A/ko not_active Application Discontinuation
-
1994
- 1994-02-17 TW TW082110880A patent/TW280813B/zh active
-
1995
- 1995-04-04 US US08/416,568 patent/US5514802A/en not_active Expired - Fee Related
-
1997
- 1997-05-16 GR GR970401106T patent/GR3023457T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2101252T3 (es) | 1997-07-01 |
| US5514802A (en) | 1996-05-07 |
| ZA939476B (en) | 1995-06-19 |
| US5434265A (en) | 1995-07-18 |
| NO301005B1 (no) | 1997-09-01 |
| HU9303680D0 (en) | 1994-04-28 |
| MX9308005A (es) | 1994-08-31 |
| DE69308514T2 (de) | 1997-07-10 |
| PL301576A1 (en) | 1994-06-27 |
| BR9305164A (pt) | 1994-11-01 |
| EP0604183A1 (en) | 1994-06-29 |
| CZ281693A3 (en) | 1994-07-13 |
| FI935777A (fi) | 1994-06-23 |
| CA2112041A1 (en) | 1994-06-23 |
| YU79693A (sh) | 1997-07-31 |
| AU667593B2 (en) | 1996-03-28 |
| AU5253093A (en) | 1994-07-07 |
| CN1098407A (zh) | 1995-02-08 |
| NO934718L (no) | 1994-06-23 |
| HUT70748A (en) | 1995-10-30 |
| NO934718D0 (no) | 1993-12-20 |
| EP0604183B1 (en) | 1997-03-05 |
| IL108091A (en) | 1998-04-05 |
| ATE149488T1 (de) | 1997-03-15 |
| DK0604183T3 (da) | 1997-05-26 |
| TW280813B (US06534493-20030318-C00329.png) | 1996-07-11 |
| JPH07179417A (ja) | 1995-07-18 |
| NZ250492A (en) | 1995-08-28 |
| DE69308514D1 (de) | 1997-04-10 |
| IL108091A0 (en) | 1994-04-12 |
| GR3023457T3 (en) | 1997-08-29 |
| FI935777A0 (fi) | 1993-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |