KR940002826B1 - 4-메틸렌-2-옥소-8-아자스피로[4,5]데칸 유도체, 그것의 이성질체, 산부가염, 제4급 암모늄염과 그것의 제조방법 및 그것을 함유하는 약제학적 조성물 - Google Patents

4-메틸렌-2-옥소-8-아자스피로[4,5]데칸 유도체, 그것의 이성질체, 산부가염, 제4급 암모늄염과 그것의 제조방법 및 그것을 함유하는 약제학적 조성물 Download PDF

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Publication number
KR940002826B1
KR940002826B1 KR1019900012168A KR900012168A KR940002826B1 KR 940002826 B1 KR940002826 B1 KR 940002826B1 KR 1019900012168 A KR1019900012168 A KR 1019900012168A KR 900012168 A KR900012168 A KR 900012168A KR 940002826 B1 KR940002826 B1 KR 940002826B1
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KR
South Korea
Prior art keywords
formula
oxo
derivative
methylene
decane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019900012168A
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English (en)
Korean (ko)
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KR910004630A (ko
Inventor
토스 에디트
퇴르레이 요세프
게르게 산도르
스즈포르니 라즐로
키스 벨라
팔로시 에바
그로오 도라
라스즈로브스즈키 이스트반
라피스 에르제베트
아우스 페렌크
가알 라즐로
Original Assignee
리히터 게데온 베기에스제티 기아르 알. 티
에바 프리드만,가보 게레브
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Filing date
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Application filed by 리히터 게데온 베기에스제티 기아르 알. 티, 에바 프리드만,가보 게레브 filed Critical 리히터 게데온 베기에스제티 기아르 알. 티
Publication of KR910004630A publication Critical patent/KR910004630A/ko
Application granted granted Critical
Publication of KR940002826B1 publication Critical patent/KR940002826B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
KR1019900012168A 1989-08-10 1990-08-08 4-메틸렌-2-옥소-8-아자스피로[4,5]데칸 유도체, 그것의 이성질체, 산부가염, 제4급 암모늄염과 그것의 제조방법 및 그것을 함유하는 약제학적 조성물 Expired - Fee Related KR940002826B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU4094/89 1989-08-10
HU894094A HU204276B (en) 1989-08-10 1989-08-10 Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
KR910004630A KR910004630A (ko) 1991-03-29
KR940002826B1 true KR940002826B1 (ko) 1994-04-04

Family

ID=10966866

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019900012168A Expired - Fee Related KR940002826B1 (ko) 1989-08-10 1990-08-08 4-메틸렌-2-옥소-8-아자스피로[4,5]데칸 유도체, 그것의 이성질체, 산부가염, 제4급 암모늄염과 그것의 제조방법 및 그것을 함유하는 약제학적 조성물
KR1019900012169A Expired - Fee Related KR940000830B1 (ko) 1989-08-10 1990-08-08 2-옥소-3, 8-디아자스피로[4,5]데칸 유도체와 그 제조방법 및 그것을 함유하는 약제학적 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019900012169A Expired - Fee Related KR940000830B1 (ko) 1989-08-10 1990-08-08 2-옥소-3, 8-디아자스피로[4,5]데칸 유도체와 그 제조방법 및 그것을 함유하는 약제학적 조성물

Country Status (26)

Country Link
US (2) US5132303A (https=)
EP (2) EP0412821B1 (https=)
JP (2) JPH0383985A (https=)
KR (2) KR940002826B1 (https=)
CN (1) CN1025031C (https=)
AT (2) ATE104671T1 (https=)
AU (2) AU621771B2 (https=)
CA (2) CA2023018C (https=)
DD (2) DD299431A5 (https=)
DE (2) DE69014008T2 (https=)
DK (1) DK0413516T3 (https=)
ES (2) ES2063923T3 (https=)
FI (1) FI93456C (https=)
HK (1) HK118295A (https=)
HU (2) HU206677B (https=)
IE (1) IE902885A1 (https=)
IL (2) IL95324A (https=)
IN (1) IN170979B (https=)
IS (1) IS3612A7 (https=)
MY (1) MY107240A (https=)
NO (1) NO903511L (https=)
NZ (2) NZ234846A (https=)
PL (2) PL164662B1 (https=)
SG (1) SG59864G (https=)
YU (2) YU150489A (https=)
ZA (3) ZA906304B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3751404T2 (de) * 1986-12-17 1995-12-21 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Bewusstseinsstörungen.
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5756743A (en) 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!
US6100256A (en) * 1996-12-02 2000-08-08 Merck Sharp & Dohme Ltd. Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
KR20030087248A (ko) * 2002-05-08 2003-11-14 (주)씨엔아이 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
CN102459278A (zh) * 2009-06-16 2012-05-16 默沙东公司 取代的-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
GB201416346D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (https=) * 1964-04-22
CH601304A5 (https=) * 1974-02-12 1978-07-14 Buskine Sa
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost

Also Published As

Publication number Publication date
DD299431A5 (de) 1992-04-16
DK0413516T3 (da) 1994-05-24
CA2023015A1 (en) 1991-02-11
EP0412821B1 (en) 1994-11-09
HUT55785A (en) 1991-06-28
ES2063923T3 (es) 1995-01-16
EP0412821A2 (en) 1991-02-13
HU903233D0 (en) 1990-10-28
JPH0383985A (ja) 1991-04-09
HU204276B (en) 1991-12-30
HK118295A (en) 1995-07-28
HUT59375A (en) 1992-05-28
DE69008275T2 (de) 1994-08-04
IN170979B (https=) 1992-06-27
ATE104671T1 (de) 1994-05-15
AU6080390A (en) 1991-02-14
ZA906304B (en) 1991-06-26
CA2023018A1 (en) 1991-02-11
YU154090A (sh) 1992-12-21
CA2023018C (en) 1995-11-28
IL95325A (en) 1994-06-24
PL163899B1 (pl) 1994-05-31
MY107240A (en) 1995-10-31
SG59864G (en) 1995-09-01
NO903511L (no) 1991-02-11
IE902885A1 (en) 1991-02-27
KR910004631A (ko) 1991-03-29
JPH0381277A (ja) 1991-04-05
FI903974A0 (fi) 1990-08-10
ES2052179T3 (es) 1994-07-01
YU150489A (sh) 1992-12-21
IL95324A (en) 1994-02-27
ATE113951T1 (de) 1994-11-15
ZA906300B (en) 1991-05-29
DE69014008T2 (de) 1995-03-23
EP0413516A2 (en) 1991-02-20
ZA906299B (en) 1991-06-26
EP0413516B1 (en) 1994-04-20
FI93456B (fi) 1994-12-30
EP0412821A3 (en) 1991-11-27
US5132303A (en) 1992-07-21
AU621771B2 (en) 1992-03-19
NZ234846A (en) 1992-03-26
KR910004630A (ko) 1991-03-29
EP0413516A3 (en) 1991-11-27
DD299428A5 (de) 1992-04-16
HU206677B (en) 1992-12-28
IL95324A0 (en) 1991-06-30
PL286443A1 (en) 1992-01-13
DE69008275D1 (de) 1994-05-26
US5132309A (en) 1992-07-21
PL291648A1 (en) 1992-06-01
NO903511D0 (no) 1990-08-09
FI93456C (fi) 1995-04-10
AU6080490A (en) 1991-02-14
NZ234843A (en) 1992-03-26
AU621238B2 (en) 1992-03-05
DE69014008D1 (de) 1994-12-15
IL95325A0 (en) 1991-06-30
KR940000830B1 (ko) 1994-02-02
PL164662B1 (pl) 1994-09-30
CN1049349A (zh) 1991-02-20
CN1025031C (zh) 1994-06-15
IS3612A7 (is) 1991-02-11

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