KR930000954A - 메로시아닌 단백오차 지시제 - Google Patents

메로시아닌 단백오차 지시제 Download PDF

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KR930000954A
KR930000954A KR1019920009664A KR920009664A KR930000954A KR 930000954 A KR930000954 A KR 930000954A KR 1019920009664 A KR1019920009664 A KR 1019920009664A KR 920009664 A KR920009664 A KR 920009664A KR 930000954 A KR930000954 A KR 930000954A
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error indicator
merocyanine
protein
protein error
test strip
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KR1019920009664A
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KR100231079B1 (ko
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에프. 코레이 폴
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프랭클린 이. 브레켄리지
마일즈 인코포레이티드
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Publication of KR930000954A publication Critical patent/KR930000954A/ko
Priority to KR1019990017315A priority Critical patent/KR100232446B1/ko
Priority to KR1019990017316A priority patent/KR100235367B1/ko
Priority to KR1019990017318A priority patent/KR100232447B1/ko
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/145—Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G01N33/523—Single-layer analytical elements the element being adapted for a specific analyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G01N33/6839—Total protein determination, e.g. albumin in urine involving dyes, e.g. Coomassie blue, bromcresol green
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

메로시아닌 단백오차 지시제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1 내지 6도는 메로시아닌 단백오차 지시제 합성 방법의 모식도이다,
제7도는 pH 2.5 에서 0.3 mM SPDIB(1-(-설포프로필)-2-(4'-하이드록시-3'-5'-디요오도스티릴)-3,3-디메틸인돌레니늄베타인)으로 함침시킨 분석용 시험 스트립의 알부민에 대한 용량 반응 곡선을 나타낸다.

Claims (10)

  1. 일반식(Ⅰ)의 메로시아닌 단백오차 지시제 화합물:
    상기식에서, m은 1내지 6의 정수이고, Q는 -Br, -I, 또는 CI이며, R은 S, Se, 0 또는 C(CnH2n+1)2(여기에서 n은 1내지 6정수이다)이고 T는 -SO3 또는 -H이다.
  2. 메로시아닌 단백오차 지시제 화합물 1-(-설포프로필)-2-(4'-하이드록시-3'-5'-디요오도스티릴)-3,3-디메틸인돌레니늄베타인.
  3. 메로시아닌 단백오차 지시제로 함침된 흡착성 담체를 함유하는, 액체 샘플중의 단백질 검출을 위한 분석용 시험 스트립.
  4. 일반적(Ⅰ) 메로시아닌 단백오차 지시제 화합물로 함침된 흡착성 담체를 함유하는, 액체 샘플중의 단백질 검출을 위한 분석용 시험 스트립.
    상기식에서, m은 1내지 6의 정수이고, Q는 -Br, -I, 또는 CI이며, R은 S, Se, 0 또는 C(Cn2n1)2(여기에서 n은 1내지 6정수이다)이고 T는 -SO3 또는 -H이다.
  5. 제4항에 있어서, m이 3 또는 4의 정수이고, Q는 -Br,또는 -I 이며, R은 C(CnH2n+1)2(여기에서 n은 1내지 3정수이다)이고, T는 -SO3 인 분석용 시험 스트립.
  6. 제4항에 있어서, m이 3이고 R은 C(CnH3)3인 분석용 시험 스트립.
  7. a)일반식(Ⅰ)의 메로시아닌 단백오차 지시제 화합물로 함침된 흡착성 담체를 함유하는 분석용 시험 스트립을 액체 샘플로 습윤시키고, b) 시험 스트립의 색변화(색변화는 액체 샘플중의 단백질의 존재를 암시한다)를 관찰 및 기록하는 단계를 포함함을 특징으로 하여, 액체 샘플중의 단백질을 검출하는 방법.
    상기식에서, m은 1내지 6의 정수이고, Q는 -Br, -I, 또는 CI이며, R은 S, Se, 0 또는 C(CnH2n+1)2(여기에서 n은 1내지 6정수이다)이고 T는 -SO3 또는 -H이다.
  8. 제7항에 있어서, 메로시아닌 단백오차 지시제 화합물 1-(-설포프로필)-2-(4'-하이드록시-3'-5'-디요오도스티릴)-3,3-디메틸인돌레니늄 베타인인 방법.
  9. a)샘플에 일반식 (Ⅰ)의 메로시아닌 단백오차 지시제 화합물을 가하고, b)색변화(색변화는 샘플중의 단백질의 존재를 암시한다)를 관찰 및 기록하는 단계를 특징으로 하여, 샘플중의 단백질을 검출하는 방법.
    상기식에서, m은 1내지 6의 정수이고, Q는 -Br, -I, 또는 CI이며, R은 S, Se, 0 또는 C(CnH2n+1)2(여기에서 n은 1내지 6정수이다)이고 T는 -SO3 또는 -H이다.
  10. 제9항에 있어서, 메로시아닌 단백오차 지시제 화합물 1-(-설포프로필)-2-(4'-하이드록시-3'-5'-디요오도스티릴)-3,3-디메틸인돌레니늄 베타인인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920009664A 1991-06-06 1992-06-04 메로시아닌 단백오차 지시제 KR100231079B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019990017315A KR100232446B1 (ko) 1991-06-06 1999-05-14 메로시아닌 단백오차 지시제를 함유하는 단백질 검출용 시험 스트립
KR1019990017316A KR100235367B1 (ko) 1991-06-06 1999-05-14 메로시아닌 단백오차 지시제를 함유하는 시험 스트립을 사용한 단백질 검출방법
KR1019990017318A KR100232447B1 (ko) 1991-06-06 1999-05-14 메로시아닌 단백오차 지시제를 사용한 단백질 검출방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7/710,955 1991-06-06
US07/710,955 US5264589A (en) 1991-06-06 1991-06-06 Merocyanine protein error indicators
US07/710,955 1991-06-06

Related Child Applications (3)

Application Number Title Priority Date Filing Date
KR1019990017315A Division KR100232446B1 (ko) 1991-06-06 1999-05-14 메로시아닌 단백오차 지시제를 함유하는 단백질 검출용 시험 스트립
KR1019990017316A Division KR100235367B1 (ko) 1991-06-06 1999-05-14 메로시아닌 단백오차 지시제를 함유하는 시험 스트립을 사용한 단백질 검출방법
KR1019990017318A Division KR100232447B1 (ko) 1991-06-06 1999-05-14 메로시아닌 단백오차 지시제를 사용한 단백질 검출방법

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US (2) US5264589A (ko)
EP (1) EP0517055B1 (ko)
JP (1) JP3153831B2 (ko)
KR (1) KR100231079B1 (ko)
AT (1) ATE143145T1 (ko)
AU (1) AU646571B2 (ko)
CA (1) CA2068002A1 (ko)
DE (1) DE69213827T2 (ko)
ES (1) ES2092596T3 (ko)
FI (1) FI922587A (ko)
GR (1) GR3021141T3 (ko)
IE (1) IE921839A1 (ko)
IL (1) IL101665A (ko)
NO (1) NO922002L (ko)
NZ (1) NZ242732A (ko)
TW (1) TW198023B (ko)
ZA (1) ZA923805B (ko)

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JP5306811B2 (ja) 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
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CN106349146A (zh) * 2016-08-11 2017-01-25 潘忠宁 一种新型光致变色材料的合成方法
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CN112876405B (zh) * 2021-01-18 2022-08-02 南开大学 一类内质网靶向激活型光敏剂的制备方法及应用

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FI922587A (fi) 1992-12-07
CA2068002A1 (en) 1992-12-07
DE69213827D1 (de) 1996-10-24
JPH05223825A (ja) 1993-09-03
TW198023B (ko) 1993-01-11
NO922002D0 (no) 1992-05-21
DE69213827T2 (de) 1997-01-30
GR3021141T3 (en) 1996-12-31
AU646571B2 (en) 1994-02-24
US5328850A (en) 1994-07-12
ZA923805B (en) 1993-03-10
IE921839A1 (en) 1992-12-16
US5264589A (en) 1993-11-23
ES2092596T3 (es) 1996-12-01
FI922587A0 (fi) 1992-06-04
IL101665A (en) 1996-10-16
EP0517055A1 (en) 1992-12-09
AU1804992A (en) 1993-03-11
EP0517055B1 (en) 1996-09-18
JP3153831B2 (ja) 2001-04-09
NO922002L (no) 1992-12-07
IL101665A0 (en) 1992-12-30
KR100231079B1 (ko) 1999-11-15
NZ242732A (en) 1994-11-25
ATE143145T1 (de) 1996-10-15

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