KR920021546A - 알도스 환원효소 억제제로서 유용한 스피로[이소퀴놀린-4(1h), 3'-피롤리딘]-1,2',3,5'(2h)-테트론 화합물의 제조방법 및 중간체 - Google Patents

알도스 환원효소 억제제로서 유용한 스피로[이소퀴놀린-4(1h), 3'-피롤리딘]-1,2',3,5'(2h)-테트론 화합물의 제조방법 및 중간체 Download PDF

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Publication number
KR920021546A
KR920021546A KR1019920008335A KR920008335A KR920021546A KR 920021546 A KR920021546 A KR 920021546A KR 1019920008335 A KR1019920008335 A KR 1019920008335A KR 920008335 A KR920008335 A KR 920008335A KR 920021546 A KR920021546 A KR 920021546A
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KR
South Korea
Prior art keywords
compound
formula
isoquinoline
spiro
pyrrolidine
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KR1019920008335A
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English (en)
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KR100217214B1 (ko
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소티리오스 맬라매스 마이클
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이건 이. 버그
아메리칸 홈 프로덕츠 코포레이션
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Publication of KR920021546A publication Critical patent/KR920021546A/ko
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Publication of KR100217214B1 publication Critical patent/KR100217214B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

알도스 환원효소 억제제로서 유용한 스피로[이소퀴놀린-4(1H),3'-피롤리딘]-1,2',3,5'(2H)-테트론 화합물의 제조방법 및 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. a) 일반식(II)의 화합물의 촉매량의 CuBr의 존재하에 디메틸 말로네이트 및 NaH와 반응시켜 일반식(III)의 화합물을 생성시키고, b) 일반식(III)의 화합물을 SOCl2와 반응시킨 다음 Et3N의 존재하에 통상적인 용매 속에서 R2NH2로 처리하여 일반식(IV)의 화합물을 생성시키고, c) 일반식(IV)의 화합물을 K2CO3의 존재하에 통상적인 용매 속에서 브로모아세토니트릴과 반응시켜 일반식(V)의 화합물을 생성시키고, d) 일반식(V)의 화합물의 메탄올 및 디에틸 에테르중의 무수 HCl 가스와 반응시켜 일반식(VI)의 화합물을 생성시키고, e) 일반식(VI)의 화합물을 통상적인 용매중의 염기와 반응시켜 일반식(I)의 화합물을 제조함을 특징으로 하는, 일반식(I)의 화합물의 제조방법.
    상기식에서, R1은 수소 또는 할로겐이고 R2는 디할로겐 치환된 벤질 또는 메틸이다.
  2. 일반식(V)의 화합물.
    상기식에서, R1은 수소 또는 할로겐이고, R2는 디할로겐 치환된 벤질 또는 메틸이다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920008335A 1991-05-22 1992-05-18 알도스 환원효소 억제제로서 유용한 스피로[이소퀴놀린-4(1h),3'-피롤리딘]-1,2',3,5'(2h)-테트론 화합물의 제조방법 및 이의 중간체 KR100217214B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/703,969 US5106978A (en) 1991-05-22 1991-05-22 Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US7/703969 1991-05-22
US07/703969 1991-05-22

Publications (2)

Publication Number Publication Date
KR920021546A true KR920021546A (ko) 1992-12-18
KR100217214B1 KR100217214B1 (ko) 1999-09-01

Family

ID=24827531

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920008335A KR100217214B1 (ko) 1991-05-22 1992-05-18 알도스 환원효소 억제제로서 유용한 스피로[이소퀴놀린-4(1h),3'-피롤리딘]-1,2',3,5'(2h)-테트론 화합물의 제조방법 및 이의 중간체

Country Status (6)

Country Link
US (1) US5106978A (ko)
JP (1) JP3474588B2 (ko)
KR (1) KR100217214B1 (ko)
CA (1) CA2068590C (ko)
CZ (1) CZ281171B6 (ko)
ZA (1) ZA923567B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103890T3 (es) * 1991-05-22 1997-10-01 American Home Prod Procedimiento y producto intermedio para producir derivados de isoquinoleina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419517A (en) 1973-06-01 1983-12-06 E. I. Du Pont De Nemours & Co. 4a-Aryl-trans-decahydroisoquinolines
DE3262294D1 (en) * 1981-05-13 1985-03-28 Ici Plc Pharmaceutical compositions containing spiro succinimide derivatives
IE883159L (en) * 1988-10-19 1990-04-19 Hydam Ltd Wave powered prime mover
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
CZ281171B6 (cs) 1996-07-17
ZA923567B (en) 1993-11-15
CA2068590C (en) 2001-12-25
CA2068590A1 (en) 1992-11-23
KR100217214B1 (ko) 1999-09-01
JPH05148264A (ja) 1993-06-15
US5106978A (en) 1992-04-21
JP3474588B2 (ja) 2003-12-08
CS145892A3 (en) 1992-12-16

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