KR830009085A - (피리딘일)-y-벤즈이미다졸 - Google Patents
(피리딘일)-y-벤즈이미다졸 Download PDFInfo
- Publication number
- KR830009085A KR830009085A KR1019820000049A KR820000049A KR830009085A KR 830009085 A KR830009085 A KR 830009085A KR 1019820000049 A KR1019820000049 A KR 1019820000049A KR 820000049 A KR820000049 A KR 820000049A KR 830009085 A KR830009085 A KR 830009085A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- benzenediamine
- lower alkyl
- pyridinyl
- hydrogen
- Prior art date
Links
- 125000004076 pyridyl group Chemical group 0.000 title claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- FBZVZUSVGKOWHG-UHFFFAOYSA-N 1,1-dimethoxy-n,n-dimethylethanamine Chemical compound COC(C)(OC)N(C)C FBZVZUSVGKOWHG-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ZSXGLVDWWRXATF-UHFFFAOYSA-N N,N-dimethylformamide dimethyl acetal Chemical compound COC(OC)N(C)C ZSXGLVDWWRXATF-UHFFFAOYSA-N 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- (가) 4-(Py-Y)-1,2-벤젠디아민과 화학식 R-C(OR1)3(R1: 저급 알킬)의 오르토(저급)알칸산트리(저급 알킬)을 반응시켜 화학식 I의 화합물을 제조하거나(나) 4-(Py-Y)-1,2-벤젠디아민과 디메틸포름아미드디메틸 아세탈 또는 디메틸아세트아미드 디메틸아세탈을 반응시켜화학식 I(R : 메틸 또는 에틸)의 화합물을 제조하거나(다) 화학식 R'-C'=O(R' : 저급 알킬)의 알칸오일을 생성하는 1몰 등량의 알칸오일화제와 4-(Py-Y)-1,2-벤젠디아민을 반응시켜 N2-[R'-C(=O)]-4-(Py-Y)-1,2-벤젠디아민을 제조하여 이것을 가열하므로서 화학식 I(R : 저급 알킬)의 화합물을 제조하거나(라) 촉매 작용에 의한 수소화 반응 제건하에서 3-니트로-N-(RCO)-4-(Py-Y)-1-벤젠디아민과 수소를 반응시키고 필요에 따라서는 생성된 유리 염기를 산첨가염으로 전환시키므로서 화학식 I 또는 II를 가진 화합물 또는 이것의 산첨가염의 제제방법.단, 위의 식에서Y : 탄소원자수가 1-2인 저급 알킬렌 또는 직접 결합군,R : 수소 또는 저급 알킬,Py : 1개 또는 2개의 저급 알킬 치환요소를 가진 4-또는 3-피리딘일 또는 4-또는 피리딘일
- 청구범위 제1항에 있어서 Py를 4-또는 3-피리딘일로 하고, Y를 직접 결합군 또는 메틸렌으로 하며, R을 수소, 메틸 또는 에틸로 함을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US223.752 | 1981-01-09 | ||
| US06/223,752 US4331671A (en) | 1981-01-09 | 1981-01-09 | 5-(Pyridinyl)-1H-benzimidazoles and 1-hydroxy-6-(pyridinyl)-1H-benzimidazoles and their cardiotonic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830009085A true KR830009085A (ko) | 1983-12-17 |
Family
ID=22837840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820000049A KR830009085A (ko) | 1981-01-09 | 1982-01-07 | (피리딘일)-y-벤즈이미다졸 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4331671A (ko) |
| EP (1) | EP0056260A1 (ko) |
| JP (1) | JPS57136583A (ko) |
| KR (1) | KR830009085A (ko) |
| AU (1) | AU7919082A (ko) |
| CA (1) | CA1188303A (ko) |
| DK (1) | DK4982A (ko) |
| FI (1) | FI820051L (ko) |
| GR (1) | GR76990B (ko) |
| IL (1) | IL64701A (ko) |
| NO (1) | NO820036L (ko) |
| PT (1) | PT74254B (ko) |
| ZA (1) | ZA8261B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4432979A (en) * | 1981-10-26 | 1984-02-21 | William H. Rorer, Inc. | Pyridone compounds |
| US4430502A (en) * | 1982-08-13 | 1984-02-07 | The Upjohn Company | Pyridinyl substituted benzimidazoles and quinoxalines |
| SE8804628D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1602648B1 (en) * | 2003-03-13 | 2013-04-17 | Idemitsu Kosan Co., Ltd. | Nitrogen-containing heterocycle derivative and organic electroluminescent element using the same |
| JP4887194B2 (ja) * | 2007-03-28 | 2012-02-29 | 株式会社ダイヘン | 溶接ロボットのロボット制御装置 |
| AU2016315881B2 (en) * | 2015-09-03 | 2019-09-19 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of DYRK1A and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026936A (en) * | 1975-08-07 | 1977-05-31 | Hoffmann-La Roche Inc. | Anthelmintic pyridine and thiazole substituted benzimidazole carbamates |
| GB1584296A (en) * | 1976-12-07 | 1981-02-11 | Kanebo Ltd | 2-substituted benzimidazole compounds |
-
1981
- 1981-01-09 US US06/223,752 patent/US4331671A/en not_active Expired - Fee Related
-
1982
- 1982-01-01 IL IL64701A patent/IL64701A/xx not_active IP Right Cessation
- 1982-01-05 AU AU79190/82A patent/AU7919082A/en not_active Abandoned
- 1982-01-06 ZA ZA8261A patent/ZA8261B/xx unknown
- 1982-01-07 KR KR1019820000049A patent/KR830009085A/ko unknown
- 1982-01-07 NO NO820036A patent/NO820036L/no unknown
- 1982-01-07 PT PT74254A patent/PT74254B/pt unknown
- 1982-01-08 CA CA000393763A patent/CA1188303A/en not_active Expired
- 1982-01-08 FI FI820051A patent/FI820051L/fi not_active Application Discontinuation
- 1982-01-08 GR GR66962A patent/GR76990B/el unknown
- 1982-01-08 EP EP82100096A patent/EP0056260A1/en not_active Withdrawn
- 1982-01-08 DK DK4982A patent/DK4982A/da not_active Application Discontinuation
- 1982-01-09 JP JP57002182A patent/JPS57136583A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0056260A1 (en) | 1982-07-21 |
| ZA8261B (en) | 1982-11-24 |
| GR76990B (ko) | 1984-09-04 |
| AU7919082A (en) | 1982-07-15 |
| PT74254B (en) | 1983-06-27 |
| IL64701A0 (en) | 1982-03-31 |
| IL64701A (en) | 1984-10-31 |
| CA1188303A (en) | 1985-06-04 |
| JPS57136583A (en) | 1982-08-23 |
| US4331671A (en) | 1982-05-25 |
| FI820051L (fi) | 1982-07-10 |
| DK4982A (da) | 1982-07-10 |
| NO820036L (no) | 1982-07-12 |
| PT74254A (en) | 1982-02-01 |
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