KR870002065A - 설페닐화 아실히드라존의 제조 방법 - Google Patents

설페닐화 아실히드라존의 제조 방법 Download PDF

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KR870002065A
KR870002065A KR1019850005926A KR850005926A KR870002065A KR 870002065 A KR870002065 A KR 870002065A KR 1019850005926 A KR1019850005926 A KR 1019850005926A KR 850005926 A KR850005926 A KR 850005926A KR 870002065 A KR870002065 A KR 870002065A
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optionally substituted
halogen elements
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치-퉁 휴 아담
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윌리암 이. 람버트 3세
롬 앤드 하스 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/18—Sulfenamides
    • C07C313/26—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C313/30—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
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  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

설페닐화 아실히드라존의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. (1) 약 20℃-100℃ 온도에서 비활성 용액 또는 용매 혼합물의 존재하에 하기 일반식(IV)의 카르보닐의 실제적인 동물량과 하기 일반식(V)의 카르보닐 히드라지드를 반응시켜 하기 일반식(II)의 히드라존 중간체를 수거하는 공정 및 (2) 약 0℃-110℃ 온도에서 염기 존재하의 비활성 용매 또는 용매 혼합물 내에서 상기 공정(1)에서 제조된 히드라존 중간체의 실질적인 동몰량을 하기 일반식(III)의 설페닐화제와 반응시켜 하기의 동일한 일반식(I)내에서 다른 화합물로 분리 또는 전환될 수 있는 하기 일반식(I)을 갖는 설페닐화 아실히드라존을 수득하는 공정을 특징으로 하는 하기 일반식(I)로 나타내어지는 화합물의 제조방법.
    [상식 중은 : R1은 수소; 시아노; 이미다졸릴, 트리아졸릴 또는 1 또는 그 이상의 동일한 또는 다른 할로겐 원소로 임의 치환된 직쇄 또는 측쇄저급(C1-C4)알킬; 또는 1 또는 그 이상의 동일한 또는 다른 할로겐 원소, 니트로, 시아노, 저급(C1-C4)알킬 또는 저급(C1-C4)알콕시로 임의 치환된 페닐이고; R2는 수소; 이미다졸릴, 트리아졸릴 또는 1 또는 그 이상의 동일한 또는 다른 할로겐 원소로 임의 치환된 직쇄 또는 측쇄(C1-C11)알킬; 저급(C1-C4)알콕시; 저급(C1-C4)티오알킬; 1 또는 그 이상의 동일한 또는 다른 할로겐 원소로 임의 치환된 저급(C2-C6)알케닐; 1 또는 그 이상의 동일한 또는 다른 할로겐 원소 또는 니트로로 임의로 치환된 복소환; 1 또는 그 이상의 동일한 또는 다른 할로겐 원소, 저급(C1-C4)알킬, 저급(C1-C4)알콕시 또는 니트로로 임의 치환된 페닐; 또는 알킬 잔기가 1-4개의 탄소원자를 가지며 페닐 고리가 1 또는 그 이상의 동일한 또는 다른 할로겐 원소, 시아노, 니트로, 저급(C1-C4)알킬, 저급(C1-C4)알콕시 또는 저급(C1-C4)할로알킬로 임의 치환된 펜알킬이며, Z는 저급(C1-C4)할로알킬이고; A는 1 또는 그 이상의 동일한 또는 다른 할로겐원소, 니트로, 시아노, 히드록시, (C1-C6)알킬, (C1-C6)할로알킬, (C1-C6)티오알킬, (C1-C6)알콕시, (C1-C6)카롭알콕시, 알릴옥시, (C1-C6)알카노일옥시, (C1-C6)알킬아미노, (C1-C6)디알킬아미노 또는 벤질옥시로 임의 치환된 페닐; 1 또는 그 이상의 동일한 또는 다른 니트로 또는 할로겐 원소로 임의 치환된 티오페닐; 1 또는 그 이상의 동일한 또는 다른 니트로 또는 할로겐 원소로 임의 치환된 푸릴; 피리딜; 또는 나프틸이며; 및 Hal은 할로겐 원소이다.]
  2. 약 0℃-110℃ 온도에서 염기 존재하의 비활성 용매 또는 용매 혼합물 내에서 하기 일반식(II)의 히드라존의 실질적인 동몰량을 하기 일반식(III)의 실페닐화제와 반응시켜 하기의 동일한 일반식(I)내에서 다른 화합물로 분리 또는 전환될 수 있는 하기 일반식(I)을 갖는 설페닐화 아실히드라존을 수득하는 공정을 특징으로 하는 하기 일반식(I)로 나타내어지는 화합물의 제조방법.
    [상기 식중 : R1은 수소; 시아노; 이미다졸릴, 트리아졸릴 또는 1 또는 그 이상의 동일한 또는 다른 할로겐 원소로 임의 치환된 직쇄 또는 측쇄 저급(C1-C4)알킬; 또는 1 또는 그 이상의 동일한 또는 다른 할로겐 원소, 니트로, 시아노, 저급(C1-C4)알킬 또는 저급(C1-C4)알콕시로 임의 치환된 페닐이고; R2는 수소; 이미다졸릴, 트리아졸릴 또는 1 또는 그 이상의 동일한 또는 다른 할로겐원소로 임의 치환된 직쇄 또는 측쇄(C1-C11)알킬; 저급(C1-C4)알콕시; 저급(C1-C4)티오알킬; 1 또는 그 이상의 동일한 또는 다른 할로겐 원소로 임의 치환된 저급(C2-C6)알케닐; 1 또는 그 이상의 동일한 또는 다른 할로겐 원소 또는 니트로로 임의 치환된 복소환; 1 또는 그 이상의 동일한 또는 다른 할로겐 원소, 저급(C1-C4)알킬, 저급(C1-C4)알콕시 또는 니트로로 임의 치환된 페닐; 또는 알킬 잔기가 1-4개의 탄소원자를 갖고, 페닐 고리는 1 또는 그 이상의 동일한 또는 다른 할로겐 원소, 시아노, 니트로, 저급(C1-C4)알킬, 저급(C1-C4)알콕시, 또는 저급(C1-C4)할로알킬로 임의 치환된 펜알킬이며; Z는 저급(C1-C4)할로알킬이고; A는 1 또는 그 이상의 동일한 또는 다른 할로겐원소, 니트로, 시아노, 히드록시, (C1-C6)알킬 (C1-C6)할로알킬, (C1-C6)티오알킬, (C1-C6)알콕시, (C1-C6)카롭알콕시, 알릴옥시, (C1-C6)알카노일옥시 (C1-C6)알킬아미노, (C1-C6)디알킬아미노 또는 벤질옥시로 임의 치환된 페닐; 1 또는 그 이상의 동일한 또는 다른 니트로 또는 할로겐 원소로 임의 치환된 티오페닐; 1 또는 그 이상의 동일한 또는 다른 니트로 또는 할로겐 원소로 임의 치환된 푸릴; 피리딜; 또는 나프틸이며; Hal은 할로겐 원소이다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850005926A 1984-08-17 1985-08-16 설페닐화 아실히드라존의 제조방법 KR900006709B1 (ko)

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US64161384A 1984-08-17 1984-08-17
JP641613 1984-08-17
US641613 1984-08-17
US75616085A 1985-07-18 1985-07-18
JP756160 1985-07-18
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JPH01501935A (ja) * 1986-04-07 1989-07-06 ジ・アップジョン・カンパニー 駆虫薬アシルヒドラゾン、使用方法および組成物
JPH10338673A (ja) * 1997-06-04 1998-12-22 Nippon Bayeragrochem Kk イソニコチン酸ヒドラジド誘導体および有害生物防除剤
CA2710039C (en) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
EP3023426A1 (en) 2008-07-17 2016-05-25 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv

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DE2557950A1 (de) * 1974-12-30 1976-07-08 Stauffer Chemical Co N-(trichlormethylthio)-, n-(tetrachloraethylthio)- oder n-(tetrachlorfluoraethylthio)-halo-benzoylanilide und ihre verwendung als fungizide
DE2838750A1 (de) * 1978-09-06 1980-03-27 Basf Ag N-sulfenylierte formanilide

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IL76074A (en) 1989-02-28
SG67888G (en) 1989-04-21
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EP0172031A1 (en) 1986-02-19
HK24389A (en) 1989-03-31
BR8503850A (pt) 1986-05-27
KR900006709B1 (ko) 1990-09-17
DE3562773D1 (en) 1988-06-23
EP0172031B1 (en) 1988-05-18
NZ213088A (en) 1989-05-29
GR851945B (ko) 1985-12-05
MX162329A (es) 1991-04-25
CA1238325A (en) 1988-06-21

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