KR830007542A - 아로일 아미노산 유도체의 제조방법 - Google Patents
아로일 아미노산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830007542A KR830007542A KR1019810005062A KR810005062A KR830007542A KR 830007542 A KR830007542 A KR 830007542A KR 1019810005062 A KR1019810005062 A KR 1019810005062A KR 810005062 A KR810005062 A KR 810005062A KR 830007542 A KR830007542 A KR 830007542A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- formula
- alkylamino
- hydroxy
- cycloalkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- 125000005239 aroylamino group Chemical group 0.000 title 1
- -1 halo compound Chemical class 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000007859 condensation product Substances 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000006396 nitration reaction Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000006277 sulfonation reaction Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 다음 일반식(Ⅱ)의 화합물을 다음 일반식(Ⅱ)의 아미노산과 반응시켜 아미드를 형성시키거나 또는 다음 일반식(Ⅳ)의 아미드와 다음 일반식(Ⅴ)의 오메가 할로 화합물과 반응시키고, 임의로 상응하는 아실화그룹을 가수분 해하여 생성되는 유리 OH,NH 또는 SH 그룹을 아실화, 알킬화, 설폰화, 니트로화, 디아조화에 이어 치환으로 얻어진 축합생성물에 도입하고, 유리 카복시 그룹을 에스테르화 또는 아미드 형태로 전환하거나 임의로 상기 화합물을 산 또는 염기로 염을 형성시킴을 특징으로하는 다음 일반식(Ⅰ)화합물 또는 약학적으로 무독한 이의 염의 제조방법.상기식에서Q는 산소, 황 또는 NH이고X 및 Y는 같거나 서로 다르며 수소할로겐, 하이드록시, 알콕시, 트리풀루오로메틸, 니트로, 카복시, 시하노, 설폰아미노, 설프히드릴, 알킬, 알케닐, 알키닐, 알카노일, 알킬멜갑토, 아미노, 알킬아미노, 디알킬아미노, 알킬설피닐 및 알킬설포닐이며,R1은 소수, 알카노일, 치환된 알카노일(여기에서 치환체는 하이드록시, 아미노 또는 사이클로알킬임), 아로일, 아릴알카노일 또는 시클로 알킬카보닐이며,n은 1내지 4의 정수이고R2및 R3는 같거나 서로 다르며 수소, 알킬, 알케닐, 알키닐, 시클로알킬, 시클로알킬알킬-아릴, 아르알킬 및 이의 치환된 유도체(여기에서 치환체는 하이드록시, 아미노, 알킬아미노, 디알킬아미노, 알콕시, 할로겐, 하이드록시, 멜캅토, 알킬멜캅토 및 니트로임)이며,M은 알킬, 알케닐, 알키닐, 시클로알킬, 시클로알킬-알킬, 아릴, 아르알킬 및 헤테로이고,Z는 하이드록시, 아미노, 알킬아미노, 디알킬아미노, 또는 알콕시이며,(여기에서 알콕시, 알카노일, 알킬멜캅토, 알킬아미노, 디알킬아미노, 알킬설피닐 및 알킬설포닐에 있어서 알킬, 알케닐 및 알키닐그룹는 및 알킬잔기에 1내지 6의 탄소원자, 사이클로알킬 그룹에는 3내지 7의 탄소원자, 아릴그룹에는 6내지 10의 탄소원자, 아릴알킬그룹에는 7내의 16의 탄소원자가 각기 함유되고 헤테로그룹은 피리딜, 퀴놀릴, 푸릴 또는 티에닐에서 선택되고) Hal은 할로겐이다.
- 제1항에 있어서, X가 수소인 방법.
- 제1항 또는 2항에 있어서, Z가 OH인 방법.
- 제1항 내지 3항에 있어서, n이 1인 방법.
- 제1항 내지 4항에 있어서 R1이 수소인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/219,051 US4440941A (en) | 1980-12-22 | 1980-12-22 | Aroyl-aminoacids, amides and esters thereof |
| US219051 | 1980-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830007542A true KR830007542A (ko) | 1983-10-21 |
Family
ID=22817640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810005062A KR830007542A (ko) | 1980-12-22 | 1981-12-22 | 아로일 아미노산 유도체의 제조방법 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4440941A (ko) |
| EP (1) | EP0054936B1 (ko) |
| JP (1) | JPS57131749A (ko) |
| KR (1) | KR830007542A (ko) |
| AT (1) | ATE20234T1 (ko) |
| AU (1) | AU546887B2 (ko) |
| CA (1) | CA1191139A (ko) |
| DE (1) | DE3174787D1 (ko) |
| ES (1) | ES508706A0 (ko) |
| IE (1) | IE52164B1 (ko) |
| IL (1) | IL64616A (ko) |
| NZ (1) | NZ199358A (ko) |
| ZA (1) | ZA818870B (ko) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3276110D1 (en) * | 1981-03-04 | 1987-05-27 | Ici Plc | Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them |
| US4717736A (en) * | 1984-01-23 | 1988-01-05 | Merck Frosst Canada, Inc. | Antagonists of slow reacting substances of anaphylaxis |
| US5240957A (en) * | 1984-01-31 | 1993-08-31 | Astra Lakemedel Akteibolag | Oxysalicylamido derivatives |
| US4560506A (en) * | 1984-05-25 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides |
| US4647555A (en) * | 1984-10-25 | 1987-03-03 | The United States Of America As Represented By The Secretary Of The Army | Esters of boron analogues of amino acids |
| GB8704671D0 (en) * | 1987-02-27 | 1987-04-01 | Shell Int Research | Glycine compounds |
| EP0284510A3 (en) * | 1987-03-24 | 1990-08-22 | Asahi Breweries, Ltd. | N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives |
| EP0384636A1 (en) * | 1989-02-21 | 1990-08-29 | FISONS plc | Pharmaceutically active compounds |
| US5801195A (en) * | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
| EP1645288A1 (en) * | 2004-10-07 | 2006-04-12 | CTG Pharma S.r.l. | New nuclear transcription factors regulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2895992A (en) * | 1959-07-21 | Process for the production of benzoic | ||
| US2603617A (en) * | 1946-08-30 | 1952-07-15 | American Cyanamid Co | Plasticizing natural and synthetic elastomers by incorporation of n-isopropyl thiosalicylamide |
| NL281394A (ko) * | 1961-07-25 | |||
| JPS5530505B2 (ko) * | 1973-02-14 | 1980-08-11 | ||
| JPS5530506B2 (ko) * | 1973-04-17 | 1980-08-11 | ||
| LU78805A1 (de) * | 1977-12-30 | 1979-07-20 | Byk Gulden Lomberg Chem Fab | Acylhydrocarbylaminoalkansaeuren,ihre herstellung und verwendung sowie sie enthaltende arzneimittel |
| EP0006217B1 (de) * | 1978-06-14 | 1982-03-31 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte Aminoalkansäuren, ihre Verwendung und Herstellung und sie enthaltende Arzneimittel |
| ES481492A1 (es) * | 1978-06-14 | 1980-03-01 | Byk Gulden Lomberg Chem Fab | Procedimiento para la preparacion de acidos acilbifenilila- minoalcanoicon. |
| JPS5742662A (en) * | 1980-08-29 | 1982-03-10 | Chugai Pharmaceut Co Ltd | Benzoic acid amide derivative |
-
1980
- 1980-12-22 US US06/219,051 patent/US4440941A/en not_active Expired - Fee Related
-
1981
- 1981-12-18 AT AT81110594T patent/ATE20234T1/de not_active IP Right Cessation
- 1981-12-18 EP EP81110594A patent/EP0054936B1/en not_active Expired
- 1981-12-18 DE DE8181110594T patent/DE3174787D1/de not_active Expired
- 1981-12-21 CA CA000392790A patent/CA1191139A/en not_active Expired
- 1981-12-22 JP JP56206268A patent/JPS57131749A/ja active Granted
- 1981-12-22 KR KR1019810005062A patent/KR830007542A/ko unknown
- 1981-12-22 IE IE3039/81A patent/IE52164B1/en unknown
- 1981-12-22 ZA ZA818870A patent/ZA818870B/xx unknown
- 1981-12-22 IL IL64616A patent/IL64616A/xx unknown
- 1981-12-22 NZ NZ199358A patent/NZ199358A/en unknown
- 1981-12-22 AU AU78761/81A patent/AU546887B2/en not_active Ceased
- 1981-12-22 ES ES508706A patent/ES508706A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE813039L (en) | 1982-06-22 |
| AU7876181A (en) | 1982-07-01 |
| JPS57131749A (en) | 1982-08-14 |
| EP0054936B1 (en) | 1986-06-04 |
| IL64616A (en) | 1985-11-29 |
| IE52164B1 (en) | 1987-07-22 |
| ZA818870B (en) | 1982-11-24 |
| US4440941A (en) | 1984-04-03 |
| EP0054936A1 (en) | 1982-06-30 |
| JPH0231707B2 (ko) | 1990-07-16 |
| CA1191139A (en) | 1985-07-30 |
| AU546887B2 (en) | 1985-09-26 |
| DE3174787D1 (de) | 1986-07-10 |
| ATE20234T1 (de) | 1986-06-15 |
| NZ199358A (en) | 1985-04-30 |
| ES8300318A1 (es) | 1982-11-01 |
| IL64616A0 (en) | 1982-03-31 |
| ES508706A0 (es) | 1982-11-01 |
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