KR920016595A - 6-히드록시피콜린산을 제조하기 위한 미생물학적 방법 - Google Patents

6-히드록시피콜린산을 제조하기 위한 미생물학적 방법 Download PDF

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KR920016595A
KR920016595A KR1019920001087A KR920001087A KR920016595A KR 920016595 A KR920016595 A KR 920016595A KR 1019920001087 A KR1019920001087 A KR 1019920001087A KR 920001087 A KR920001087 A KR 920001087A KR 920016595 A KR920016595 A KR 920016595A
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acid
picolinic acid
salts
soluble salts
picolinic
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KR1019920001087A
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KR100233330B1 (ko
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키에너 안드레아스
글랙크러 라이너
하인쯔만 클라우스
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하인즈 모저, 비트 라우버
론자 리미티드
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/05—Alcaligenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S435/00—Chemistry: molecular biology and microbiology
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/829—Alcaligenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas

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Abstract

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Description

6-히드록시피콜린산을 제조하기 위한 미생물학적 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 피콜린산을 유일한 탄소-, 질소- 및 에너지원으로하여 생장하는 슈도모나스(Pseudomonas), 바실루스(Bacillus), 알칼리게네스(Alcaligenes), 아애로코커스(Aerococcus) 또는 로도토루라(Rhodotorula)속의 미생물을 사용하여 피콜린산 및/또는 그의 염을 히드록시화시키고, 이때 피콜린산 및/또는 그의 염의 농도를 6-히드고시피콜린산이 더 이상 대사되지 않게 선택하는 것을 특징으로 하는 6-히드록시피콜린산을 제조하는 미생물학적 방법.
  2. 제1항에 있어서, DSM에 수탁번호 6269로 기탁된 알칼리게네스 파애칼리스(Alcaligenes faecalis)또는 그의 후대 및 변종을 사용하여 히드록시화를 실행하는 것을 특징으로 하는 방버.
  3. 제1항 또는 제2항에 있어서, 피콜린산 및/또는 그의 염의 농도가 10중량%를 넘지 않게 선택되는 것을 특징으로 하는 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 10내지 60℃의 온도 및 pH 4내지 10에서 히드록시화를 실행하는 것을 특징으로 하는 방법.
  5. DSM에 수탁번호 6269로 기탁된 미생물 알칼리게네스 파애칼리스(Alcaligenes faecalis)와 그의 후대 및 변종.
  6. a) 피콜린산- 및/또는 그의 가용성 염을 이용하는 바이오매스를, 무기산에 대한 피콜린산 및/또는 그의 가용성 염의 몰비율이 1내지 8이고, 생장 단계 동안 이 배율로 유지되는 피콜린산 및/또는 가용성 염 및 무기산으 사용하여 배양하고, 또 b) 상기 바이오매스를 사용하여 피콜린산 및/또는 그의 가용성 염을 히드록시화시키는 것을 특징으로 하는 6-히드록시피콜린산을 제조하기 위한 미생물학적 방법.
  7. 제6항에 있어서, a) 단계에서,무기산에 대한 피콜린산 및/또는 그의 가용성 염의 몰비율을, 폐기 가스중 이산화 탄소에 대한 산소 비율의 측정 및/또는 pH값을 측정하는 동안에 조정하는 것을 특징으로 하는 방법.
  8. 제6항 또는 제7항에 있어서, a) 단계에서 무기산인 황산을, 황산에 대한 피콜린산 및/또는 그의 가용성 염의 몰비율 3 내지 5로 사용하는 것을 특징으로 하는 방법.
  9. 제6항 내지 제8항 중 어느 한 항에 있어서, a) 단계에서의 배양 및 b) 단계에서의 히드록시화를 15 내지 50℃의 온도 및 pH 5 내지 9에서 실행하는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920001087A 1991-02-04 1992-01-24 6-히드록시피콜린산을 제조하기 위한 미생물학적 방법 KR100233330B1 (ko)

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CH33091 1991-02-04
CH330/91-2 1991-02-04

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KR100233330B1 KR100233330B1 (ko) 1999-12-01

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US (1) US5182197A (ko)
EP (1) EP0498316B1 (ko)
JP (1) JP3098310B2 (ko)
KR (1) KR100233330B1 (ko)
AT (1) ATE127525T1 (ko)
CA (1) CA2060534C (ko)
CZ (1) CZ279492B6 (ko)
DE (1) DE59203506D1 (ko)
DK (1) DK0498316T3 (ko)
IE (1) IE69844B1 (ko)
IL (1) IL100819A (ko)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100248277B1 (ko) * 1992-02-26 2000-03-15 미우라 아끼라 6-히드록시 질소 함유 6 원환 화합물 제조방법

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238830A (en) * 1991-02-04 1993-08-24 Lonza Ltd. Microbiological process for the production of 6-hydroxypicolinic acid
US5264361A (en) * 1991-03-18 1993-11-23 Lonza Ltd. Microbiological process for the production of 6-hydroxypicolinic acid
US5266469A (en) * 1991-03-18 1993-11-30 Lonza Ltd. Microbiological process for the production of 6-hydroxynicotinic acid
US5264362A (en) * 1991-03-18 1993-11-23 Lonza Ltd. Microbiological process for the production of 6-hydroxynicotinic acid
JPH0728750B2 (ja) * 1991-03-30 1995-04-05 池田食研株式会社 微生物によるピラジン酸の水酸化物の製造方法
CZ282939B6 (cs) * 1992-03-04 1997-11-12 Lonza A.G. Mikrobiologický způsob hydroxylace dusíkatých heterocyklických karboxylových kyselin
US5270203A (en) * 1992-03-13 1993-12-14 Lonza Ltd. Biologically pure culture of Alcaligenes faecalis DSM 6335
JP4547983B2 (ja) * 2004-05-13 2010-09-22 有機合成薬品工業株式会社 ６−ヒドロキシピコリン酸の製造方法
KR20070010527A (ko) * 2005-07-19 2007-01-24 주식회사 엘지화학 6환 질소함유 화합물의 위치 선택적 수산화반응을 촉매하는미생물 및 이를 이용한 수산화된 6환 질소함유 화합물의제조방법

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
CH658866A5 (de) * 1984-02-21 1986-12-15 Lonza Ag Verfahren zur herstellung von 6-hydroxynikotinsaeure.
US4859592A (en) * 1985-07-26 1989-08-22 Hagedorn Scott R Production of picolinic acid and pyridine products via pseudomonas
IE70430B1 (en) * 1990-02-13 1996-11-27 Lonza Ag Microbiological oxidation of methyl groups in heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100248277B1 (ko) * 1992-02-26 2000-03-15 미우라 아끼라 6-히드록시 질소 함유 6 원환 화합물 제조방법

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DK0498316T3 (da) 1995-10-23
CZ279492B6 (cs) 1995-05-17
CA2060534A1 (en) 1992-08-05
EP0498316B1 (de) 1995-09-06
IE69844B1 (en) 1996-10-02
IL100819A (en) 1996-10-16
ATE127525T1 (de) 1995-09-15
CS29892A3 (en) 1992-09-16
IE920299A1 (en) 1992-08-12
CA2060534C (en) 2001-04-03
SK278496B6 (en) 1997-07-09
KR100233330B1 (ko) 1999-12-01
JP3098310B2 (ja) 2000-10-16
IL100819A0 (en) 1992-09-06
DE59203506D1 (de) 1995-10-12
EP0498316A1 (de) 1992-08-12
JPH04316490A (ja) 1992-11-06
US5182197A (en) 1993-01-26

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