KR920014802A - 테트라졸 유도체, 이의 제조방법 및 이의 용도 - Google Patents
테트라졸 유도체, 이의 제조방법 및 이의 용도 Download PDFInfo
- Publication number
- KR920014802A KR920014802A KR1019920001269A KR920001269A KR920014802A KR 920014802 A KR920014802 A KR 920014802A KR 1019920001269 A KR1019920001269 A KR 1019920001269A KR 920001269 A KR920001269 A KR 920001269A KR 920014802 A KR920014802 A KR 920014802A
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- South Korea
- Prior art keywords
- compound
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- methyl
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Reinforced Plastic Materials (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 분리된 레트 대동맥에서 물질(1)의 수축력을 나타낸 것이고, 제2도는 분리된 레트 대동맥에서 Dup753의 수축력을 나타낸 것이며, 제3도는 앤지오텐신(Ⅱ)에 대한 Dup 753 및 물질(1)의 효과로 정압성 아나에스테티화된 레트에서 동맥 혈압의 증가를 나타낸다.
Claims (10)
- 일반식(Ⅰ)의 신규한 테트라졸 유도체 및 이의 약제학적으로 허용되는 염.상기식에서, R1은 포화되거나 불포화된 직쇄 또는 측쇄(C1-C8)알킬 라디칼이고, R2는 메틸 또는 에틸이다.
- 제1항에 있어서, R1인 부틸인 일반식(Ⅰ)의 화합물.
- 5-(4'-(2-부틸-4-클로로-5-(3-메틸-1,2,4-옥사디아졸-5-일)-1-이미다졸릴메틸)비페닐-2-일)-1H-테트라졸.
- 일반식(Ⅱ)의 화합물을 불활성 대기 가스하에, 반응조건하에서 불활성인 유기 희석제중에서, 일반식(Ⅲ)의 화합물과 반응시켜 일반식(Ⅳ)의 화합물을 수득한 다음, 보호그룹을 제거함을 특징으로 하여, 일반식(Ⅰ)의 화합물 및 이의 약제학적으로 허용되는 염을 제조하는 방법.상기식에서, R1은 포화되거나 불포화된 직쇄 또는 측쇄(C1-C8)알킬 라디칼이고, R2는 메틸 또는 에틸이며, R3는 메틸 또는 에틸이고, S는 보호 그룹이며, Me는 나트륨 또는 칼륨이다.
- 제4항에 있어서, 보호 그룹을 강산으로 처리하거나 저급 지방족 알콜과 함께 가열하여 분리시킴을 특징으로 하는 방법.
- 제4항에 있어서, 보호그룹으로서 트리페닐메틸 그룹을 사용함을 특징으로 하는 방법.
- 제1항에 따르는 일반식(Ⅰ)의 화합물 및 이의 염과 함께 통상적인 약제학적 보조제 및/또는 부형제를 함유하는 약제학적 제제.
- 제1항에 따르는 일반식(Ⅰ)의 화합물 및 이의 염과 함께 다른 치료학적으로 유용한 활성 화합물 및 통상적인 약제학적 보조제 및/또는 부형제를 함유하는 약제학적 제제.
- 앤지오텐신(Ⅱ)를 억제시킴으로서 완화시키거나 치료할 수 있는 질환을 치료하기 위한 약제의 활성 성분으로서 사용하기 위한 제 1항에 따르는 화합물 및 이의 염.
- 제1항에 따르는 화합물의 혈압 강하 약제로서의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATA209/91 | 1991-01-31 | ||
AT0020991A AT395853B (de) | 1991-01-31 | 1991-01-31 | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920014802A true KR920014802A (ko) | 1992-08-25 |
Family
ID=3484393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920001269A KR920014802A (ko) | 1991-01-31 | 1992-01-29 | 테트라졸 유도체, 이의 제조방법 및 이의 용도 |
Country Status (27)
Country | Link |
---|---|
US (1) | US5254574A (ko) |
EP (1) | EP0497121B1 (ko) |
JP (1) | JPH0641099A (ko) |
KR (1) | KR920014802A (ko) |
CN (1) | CN1034662C (ko) |
AT (2) | AT395853B (ko) |
AU (1) | AU642575B2 (ko) |
CA (1) | CA2060387A1 (ko) |
CZ (1) | CZ27592A3 (ko) |
DE (1) | DE59208058D1 (ko) |
DK (1) | DK0497121T3 (ko) |
EG (1) | EG19886A (ko) |
ES (1) | ES2100242T3 (ko) |
FI (1) | FI920349A (ko) |
GR (1) | GR3022686T3 (ko) |
HU (1) | HUT62583A (ko) |
IE (1) | IE914501A1 (ko) |
IL (1) | IL100621A (ko) |
LT (1) | LTIP1518A (ko) |
LV (1) | LV10446B (ko) |
MY (1) | MY106314A (ko) |
NO (1) | NO179837C (ko) |
NZ (1) | NZ241293A (ko) |
RU (1) | RU2078764C1 (ko) |
SI (1) | SI9210026A (ko) |
YU (1) | YU48089B (ko) |
ZA (1) | ZA92155B (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1255802B (it) * | 1992-08-07 | 1995-11-16 | Luso Farmaco Inst | Derivati imidazolici ad attivita' a ii antagonista |
GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
ES2348300T3 (es) * | 2003-08-27 | 2010-12-02 | Zentiva, K.S. | Procedimiento para eliminar el grupo protector trifenilmetano. |
US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
DE102013202306B4 (de) | 2013-02-13 | 2014-12-18 | Adidas Ag | Sohle für einen Schuh |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
USD776410S1 (en) | 2013-04-12 | 2017-01-17 | Adidas Ag | Shoe |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
USD783264S1 (en) | 2015-09-15 | 2017-04-11 | Adidas Ag | Shoe |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2860691D1 (en) * | 1977-07-12 | 1981-08-13 | Synthelabo | 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions |
US4771051A (en) * | 1985-05-17 | 1988-09-13 | A/S Ferrosan | 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
DE3627155A1 (de) * | 1986-08-11 | 1988-02-18 | Schering Ag | Imidazol-derivate |
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
DE69025473T2 (de) * | 1989-06-30 | 1996-10-17 | Du Pont | Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii |
-
1991
- 1991-01-31 AT AT0020991A patent/AT395853B/de not_active IP Right Cessation
- 1991-12-20 IE IE450191A patent/IE914501A1/en not_active Application Discontinuation
- 1991-12-31 US US07/815,199 patent/US5254574A/en not_active Expired - Fee Related
-
1992
- 1992-01-06 MY MYPI92000021A patent/MY106314A/en unknown
- 1992-01-09 ZA ZA92155A patent/ZA92155B/xx unknown
- 1992-01-09 IL IL10062192A patent/IL100621A/en not_active IP Right Cessation
- 1992-01-09 NO NO920122A patent/NO179837C/no unknown
- 1992-01-11 EP EP92100380A patent/EP0497121B1/de not_active Expired - Lifetime
- 1992-01-11 DK DK92100380.2T patent/DK0497121T3/da active
- 1992-01-11 AT AT92100380T patent/ATE149164T1/de not_active IP Right Cessation
- 1992-01-11 DE DE59208058T patent/DE59208058D1/de not_active Expired - Fee Related
- 1992-01-11 ES ES92100380T patent/ES2100242T3/es not_active Expired - Lifetime
- 1992-01-13 SI SI9210026A patent/SI9210026A/sl unknown
- 1992-01-13 YU YU2692A patent/YU48089B/sh unknown
- 1992-01-14 NZ NZ241293A patent/NZ241293A/xx unknown
- 1992-01-27 FI FI920349A patent/FI920349A/fi not_active Application Discontinuation
- 1992-01-28 CN CN92100683A patent/CN1034662C/zh not_active Expired - Fee Related
- 1992-01-28 EG EG5792A patent/EG19886A/xx active
- 1992-01-29 KR KR1019920001269A patent/KR920014802A/ko not_active Application Discontinuation
- 1992-01-29 JP JP4014218A patent/JPH0641099A/ja not_active Withdrawn
- 1992-01-30 CA CA002060387A patent/CA2060387A1/en not_active Abandoned
- 1992-01-30 RU SU925010741A patent/RU2078764C1/ru active
- 1992-01-30 HU HU9200292A patent/HUT62583A/hu unknown
- 1992-01-30 AU AU10634/92A patent/AU642575B2/en not_active Ceased
- 1992-01-30 CZ CS92275A patent/CZ27592A3/cs unknown
-
1993
- 1993-11-30 LV LVP-93-1285A patent/LV10446B/lv unknown
- 1993-12-03 LT LTIP1518A patent/LTIP1518A/xx not_active Application Discontinuation
-
1997
- 1997-02-27 GR GR970400249T patent/GR3022686T3/el unknown
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