KR920012073A - 크로만 유도체 - Google Patents
크로만 유도체 Download PDFInfo
- Publication number
- KR920012073A KR920012073A KR1019910021972A KR910021972A KR920012073A KR 920012073 A KR920012073 A KR 920012073A KR 1019910021972 A KR1019910021972 A KR 1019910021972A KR 910021972 A KR910021972 A KR 910021972A KR 920012073 A KR920012073 A KR 920012073A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- cnh
- pyridazinyl
- cyano
- nso
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 일반식(I)의 크로만 유도체 및 이의 염.상기식에서 R1은 A이고, R2, R8및 R9은 각각 H 또는 A이고, R1및 R2는 함께 탄소수 3 내지 6의 알킬렌이고, R3는 H, OH, OA 또는 OR10이고, R4는 H이고, R3및 R4는 함께 결합을 갖고, R5는 피리딜, 피리다지닐, 피리미디닐, 피라지닐, 옥소디히드로피리딜, 옥소디히드로피리다지닐, 오소디히드로피리미디닐 또는 옥소디히드로피라지닐의 라디칼로, 이 라디칼은 A, F, CL, Br, I, OH, OA, OR10, SH, NO2, NH2, R10NH, HOOC 및/또는 AOOC로 치환되지 않았거나, 단치환 또는 이치환된 라디칼이고, R6및 R7은 각각 H, A, HO, AO, CHO, ACO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, HO-CnH2n, HS-CnH2n, NO2, NH2, NHA, NA2, CN, F, Cl, Br, I, CF3, ASO, ASO2, AO-SO2, R10NH, AO-CO-NH, H2NSO, HANSO, A2NSO, H2NSO2, HANSO2, A2NSO2, N2NCO, HANCO, A2NCO, H2NCS, HANCS, A2NCS, ASONH, ASO2NH, AOSONH, AOSO2NH, ACO-CnH2n, 니트로-CnH2n, 시아노-CnH2n, A-C(=NOH) 또는 A-C(=NNH2)이고, A는 탄소수 1 내지 6의 알킬이고, R10은 탄소수 1 내지 8의 알칸오일 또는 탄소수 7내지 11의 아로일이고, n은 1내지 6의 수이다.
- a) 2, 2-디메틸-4-(1-메틸-1, 6-디히드로-6-옥소-3-피리다지닐-아미노)-6-시아노-3-크로만을, b) 트란스-3, 4-디히드로-4-(1, 6-디히드로-1-메틸-6-옥소-3-피리다지닐-아미노)-2,2,3-트리메틸-6-시아노-3-크로만올, c) (4R, 3R)-2,2-디메틸-4-(1-메틸-1, 6-디히드로-6-옥소-3-피리다지닐-아미노-6-시아노-3-크로만올, d) 2, 2-디메틸-4-〔N-(1-메틸-6-옥소-3-피리다지닐)-1-메틸아미노〕-6-시아노-3-크로만올.
- 일반식(II)의 크로만올(상기식에서, X-Y는또는 -CHE-CR3R8이며, E는 C1, Br, I 또는 반응적으로 에스테르화 할 수 있는 OH 그룹이고, R1, R2, R3, R6, R7및 R8은 일반식(I)에서 정의한 바와 같다.) 일반식(III)의 화합물과R5-NH-R9(III)(상기식에서, R5, R9은 일반식(I)에서 정의한 바와 같다) 또는 이의 반응성 유도체중 하나와 반응시키고/시키거나, R3가 OH이고 R4는 H인 일반식(I)의 화합물은 탈수하고/하거나, 일반식(I)의 화합물에서, 라디칼 R3, R5, R6및 R7중의 하나 또는 그이상을 다른 라디칼 R3, R5, R6, R7로 전환시키고/시키거나 일반식(I)의 염기성 화합물을 산으로 처리하여 산부가 염중 하나로 전환시키는 것을 특징으로 하는 제1항에 따른 일반식(I)의 크로만 유도체를 제조하는 방법.
- 일반식(I)의 화합물 및/또는 이의 생리학적으로 허용가능한 염중 하나를 적어도 하나의 고형, 액형 또는 반고형 부형제 또는 보조제와 함께 투여에 적합한 형태로 전환시키는 것을 특징으로 하는 약학적 제제의 제조방법.
- 일반식(I)의 적어도 하나의 화합물 및/또는 이의 생리학적으로 허용가능한 염중 하나를 함유하는 약학적 제제.
- 질병 치료용의 일반식(I)의 화합물.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4038752A DE4038752A1 (de) | 1990-12-05 | 1990-12-05 | Chromanderivate |
DEP4038752.6 | 1990-12-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920012073A true KR920012073A (ko) | 1992-07-25 |
KR100220002B1 KR100220002B1 (ko) | 1999-09-01 |
Family
ID=6419627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910021972A KR100220002B1 (ko) | 1990-12-05 | 1991-12-02 | 크로만 유도체 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5238937A (ko) |
EP (1) | EP0489327B1 (ko) |
JP (1) | JPH04300880A (ko) |
KR (1) | KR100220002B1 (ko) |
AT (1) | ATE166649T1 (ko) |
AU (1) | AU645373B2 (ko) |
CA (1) | CA2056845A1 (ko) |
CZ (1) | CZ280911B6 (ko) |
DE (2) | DE4038752A1 (ko) |
DK (1) | DK0489327T3 (ko) |
ES (1) | ES2119751T3 (ko) |
GR (1) | GR3027561T3 (ko) |
HU (1) | HU215518B (ko) |
IE (1) | IE914213A1 (ko) |
PT (1) | PT99688B (ko) |
SK (1) | SK279095B6 (ko) |
TW (1) | TW209863B (ko) |
ZA (1) | ZA919573B (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
CA2153498A1 (en) | 1993-11-10 | 1995-05-18 | Hidetsura Cho | Chroman derivative and medicinal use thereof |
US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
KR20070003349A (ko) * | 2005-07-01 | 2007-01-05 | 한 성 육 | 가설 철도교용 체결장치 |
WO2007027780A2 (en) * | 2005-09-01 | 2007-03-08 | Janssen Pharmaceutica N.V. | Benzopyran and pyranopyridine derivatives as potassium channel openers |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3835011A1 (de) * | 1988-10-14 | 1990-04-19 | Merck Patent Gmbh | Chromanderivate |
CH674984A5 (ko) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
AU628331B2 (en) * | 1988-05-06 | 1992-09-17 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
-
1990
- 1990-12-05 DE DE4038752A patent/DE4038752A1/de not_active Withdrawn
-
1991
- 1991-11-25 AT AT91120050T patent/ATE166649T1/de not_active IP Right Cessation
- 1991-11-25 DK DK91120050T patent/DK0489327T3/da active
- 1991-11-25 ES ES91120050T patent/ES2119751T3/es not_active Expired - Lifetime
- 1991-11-25 DE DE59108997T patent/DE59108997D1/de not_active Expired - Fee Related
- 1991-11-25 EP EP91120050A patent/EP0489327B1/de not_active Expired - Lifetime
- 1991-11-29 AU AU88313/91A patent/AU645373B2/en not_active Ceased
- 1991-12-02 KR KR1019910021972A patent/KR100220002B1/ko not_active IP Right Cessation
- 1991-12-03 TW TW080109502A patent/TW209863B/zh active
- 1991-12-03 CA CA002056845A patent/CA2056845A1/en not_active Abandoned
- 1991-12-04 PT PT99688A patent/PT99688B/pt not_active IP Right Cessation
- 1991-12-04 IE IE421391A patent/IE914213A1/en unknown
- 1991-12-04 US US07/802,093 patent/US5238937A/en not_active Expired - Fee Related
- 1991-12-04 SK SK3674-91A patent/SK279095B6/sk unknown
- 1991-12-04 HU HU913797A patent/HU215518B/hu not_active IP Right Cessation
- 1991-12-04 CZ CS913674A patent/CZ280911B6/cs not_active IP Right Cessation
- 1991-12-04 JP JP3357437A patent/JPH04300880A/ja active Pending
- 1991-12-04 ZA ZA919573A patent/ZA919573B/xx unknown
-
1998
- 1998-08-04 GR GR980401745T patent/GR3027561T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU215518B (hu) | 1999-01-28 |
DK0489327T3 (da) | 1999-03-22 |
DE59108997D1 (de) | 1998-07-02 |
AU645373B2 (en) | 1994-01-13 |
JPH04300880A (ja) | 1992-10-23 |
CS367491A3 (en) | 1992-06-17 |
DE4038752A1 (de) | 1992-06-11 |
PT99688A (pt) | 1992-10-30 |
HU913797D0 (en) | 1992-02-28 |
HUT62000A (en) | 1993-03-29 |
AU8831391A (en) | 1992-06-11 |
ES2119751T3 (es) | 1998-10-16 |
GR3027561T3 (en) | 1998-11-30 |
PT99688B (pt) | 1999-05-31 |
EP0489327A1 (de) | 1992-06-10 |
US5238937A (en) | 1993-08-24 |
CA2056845A1 (en) | 1992-06-06 |
IE914213A1 (en) | 1992-06-17 |
TW209863B (ko) | 1993-07-21 |
EP0489327B1 (de) | 1998-05-27 |
ZA919573B (en) | 1992-08-26 |
CZ280911B6 (cs) | 1996-05-15 |
ATE166649T1 (de) | 1998-06-15 |
KR100220002B1 (ko) | 1999-09-01 |
SK279095B6 (sk) | 1998-06-03 |
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LAPS | Lapse due to unpaid annual fee |