KR920005765A - 고체상에 대한 알레르겐의 결합 - Google Patents

고체상에 대한 알레르겐의 결합 Download PDF

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KR920005765A
KR920005765A KR1019910005827A KR910005827A KR920005765A KR 920005765 A KR920005765 A KR 920005765A KR 1019910005827 A KR1019910005827 A KR 1019910005827A KR 910005827 A KR910005827 A KR 910005827A KR 920005765 A KR920005765 A KR 920005765A
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allergen
solid phase
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에이. 아나위스 마크
이. 린드버그 로져
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챨스 엠. 브록
에보트 래보러토리즈
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S436/00—Chemistry: analytical and immunological testing
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

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Abstract

내용 없음

Description

고체상에 대한 알레르겐의 결합
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. a) 고체 상, 및 b) 고체 상에 고정화된 하나 이상의 알레르겐(이 알레르겐은 알레르겐 조성물로서 적용되며, 알레르겐 조성물은 변성제, 유기 용매, 가교결합제 및 농축된 염 용액으로 이루어진 그룹중에서 선택된 예비처리물질과 알레르겐의 혼합물을 포함한다)을 포함하는, 시험 샘플중의 1gE의 존재 여부 또는 이의 양을 줄이기 위한 장치.
  2. 제 1 항에 있어서, 고체상이 셀룰로오즈, 셀룰로오즈 유도체, 실리카, 유리섬유, 다공성 중합체 매트릭스, 다공성 겔, 중합체 필름, 아가로오즈 및 다공성 섬유 매트릭스로 이루어진 그룹중에서 선택되는 장치.
  3. a)고체상에 알레르겐 조성물(이 알레르겐 조성물은 변성제, 유기 용매, 가교결합제 및 농축된 염 용액으로 이루어진 그룹중에서 선택된 예비처리 물질과 알레르겐의 혼합물을 포함한다)을 적용하고, b)고체상을 건조시킴으로써 알레르겐을 고체상에 고정화시키는 단계를 포함하여 제1항에 따른 장치를 제조하는 방법.
  4. a) 알레르겐 용액이 생성되도록 용매에 용해된 알레르겐, 및 b)변성체, 유기 용매, 가교결합제 및 농축된 염 용액으로 이루어진 그룹중에서 선택된 예비처리 물질을 포함하며, 알레르겐 용액을 예비처리 물질과 혼합함으로써 생성되고 시험 샘플중의 1gE의 존재여부 또는 이의 양을 시험관내 검출시 사용하기 위한 알레르겐 조성물.
  5. 제 4 항에 있어서, 예비처리 물질이 염산, 아세트산, 테트라하이드로푸란, 염화나트륨 용액, 포름알데하이드, 글루타르알데하이드 및 1-에틸-3-(3-디메틸아미노프로필)카보디이미드로 이루어진 그룹중에서 선택된 알레르겐 조성물.
  6. 제 3 항에 있어서, 알레르겐 조성물이, 수중 알레르겐 프로레인을 기준으로 하여, 하기 성분 ⅰ)내지 (xxⅷ)를 함유하는 방법.
  7. a) 변성제, 유기용매, 가교결합제 및 농축된 염용액으로 이루어진 그룹중에서 선택된 예비처리물질을 알레르겐과 혼합하고, b) 이 알레르겐 조성물을 고체상에 고정화하고, c) 시험 샘플을 고체 상에 접촉시킴으로써, 시험 샘플로부터의 알레르겐-특히 IgE항체를 고체 상에 고정화시켜 알레르겐/항체 복합체를 생성시키고, d) 고정화된 알레르겐-특히 IgE항체를 검출하여 시험 샘플중의 IgE의 존재 여부 또는 이의 양을 측정하는 단계를 포함하여 시험 샘플중의 IgE의 존재 여부 또는 이의 양을 특정하는 방법.
  8. 제 7 항에 있어서, 예비처리물질이 염산, 아세트산, 테트라하이드로푸란, 염화나트륨 용액, 포름알데하이드, 글루타르알데하이드 및 1-에틸-3-(3-디메틸아미노프로필)카보디이미드로 이루어진 그룹중에서 선택된 방법.
  9. a) Ⅰ) 알레르겐 용액이 생성되도록 용매에 용해된 알레르겐 및 Ⅱ) 변성제, 유기 용매, 가교결합제 및 농축된 염 용액으로 이루어진 그룹중에서 선택된 예비처리 물질을 포함하며, 알레르겐 용액을 예비처리 물질과 혼합시켜 생성된 알레르겐 조성물로서의 알레르겐 하나 이상을 고체 상에 적용하여 고체상에 고정화시키고, b) 시험 샘플을 고체 상에 접촉시킴으로써, 시험 샘플로부터의 알레르겐-특히 IgE를 고체 상에 고정화하여 알레르겐/항체 복합체를 생성시키고, c)고정화된 알레르겐-특히 IgE를 검출하여 시험 샘플중의 IgE의 존재여부 또는 이의 양을 측정하는 단계를 포함하여 시험 샘플중의 IgE의 존재여부 또는 이의 양을 측정하는 방법.
  10. a) Ⅰ) 알레르겐 용액이 생성되도록 용매에 용해된 알레르겐 및 Ⅱ) 변성제, 유기 용매, 가교결합제 및 농축된 염 용액으로 이루어진 그룹중에서 선택된 예비처리 물질을 포함하는 알레르겐 조성물로서 고체 상에 적용하여 고체 상에 고정화된 알레르겐, 및 b)시험 샘플중의 IgE의 존재여부 또는 이의 양을 측정하기 위한 지시 제〔이 지시제는 알레르겐, IgE및 보조적 특이 결합원으로 이루어진 그룹중에서 선택된 어느 하나에 특이한 결합맴버에 결합된 라벨(label)을 포함한다〕을 포함하는, 시험 샘플중의 IgE의 존재 여부 또는 이의 양을 측정하기 위한 키트(kit).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910005827A 1990-04-13 1991-04-12 고체상에 대한 알레르겐의 결합 KR920005765A (ko)

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US509255 1990-04-13
US07/509,255 US5091318A (en) 1990-04-13 1990-04-13 Binding of allergens to a solid phase

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EP (1) EP0451800A1 (ko)
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CA2039958A1 (en) 1991-10-14
JPH04225163A (ja) 1992-08-14
US5091318A (en) 1992-02-25
EP0451800A1 (en) 1991-10-16
AU634647B2 (en) 1993-02-25
AU7433091A (en) 1991-10-17

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