KR920003324B1 - Whitening cosmetics - Google Patents

Abstract

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Description

Color cosmetics

Figure is a diagram showing the dopa (chromium) generation of the active ingredient of the present invention.

The present invention relates to color whitening cosmetics containing the extract of animal organs.

Various color whitening cosmetics have been provided or researched since ancient times in order to remove spots such as blemishes and freckles on the skin, and to bring a whitening effect of the entire skin.

In the past, peroxides such as hydrogen peroxide, zinc peroxide, magnesium peroxide, sodium peroxide, and zinc perborate were formulated in cosmetics, but since these peroxides are extremely unstable substances, they have difficulty in preservability or formulation to cosmetics and their color whitening effect. Whitening effect) could not be said to be sufficient.

Since then, cosmetics containing vitamin C, cysteine and colloidal sulfur have been used, but have not yet been sufficiently satisfactory.

Recently, koji acid obtained by culturing bacteria such as Koji bacteria as a whitening component of these color whitening cosmetics has an effect on whitening of the skin, and color whitening cosmetics using koji acid have been known.

For example, Japanese Patent Application Laid-Open No. 56-18569, Japanese Patent Laid-Open No. 53-3538, and derivatives of koji acid have also been studied, and cosmetics containing koji acid derivatives are also known.

For example, Japanese Patent Application Laid-Open Nos. 56-7710, 56-7776, 56-79616, and cosmetics containing pyrone compounds, chromone compounds, and flavonol compounds are also known.

For example, Japanese Patent Application Laid-Open Nos. 53-3538, 55-92305, 55-111410, 55-111411, 55-143908, 55-157580, 57-14517, 57-35506, Publication No. 58-131911.

In addition, cosmetics containing placenta extract in cosmetics are also presented. For example, JP 35-15399.

In order to further enhance the whitening effect of the placenta extract, which is an extract of animal organs, in the various color cosmetics presented above, an object of the present invention is to provide a cosmetic having a whitening effect of conventional color white cosmetics or more by use with various animal organ components. will be.

The present invention is a cosmetic having an extremely excellent color whitening effect by containing a placenta extract and animal liver extract.

Placenta extract used in the present invention is to extract the water-soluble part with water through a means such as washing the placenta of humans or cows, blood clotting, crushing freezing, etc. It is an aqueous solution obtained by removing.

Placenta extract used in the present invention is generally marketed as placenta extract (extract) and is mainly used as a raw material for cosmetics, any of those condensed in humans, condensed in animals such as cattle, etc. Placenta extract is suitable.

The liver extract of the animal used in the present invention is extracted by crushing the liver of the animal, and then crushed to make a porridge after squeezing the liver of water such as mammals such as cows, pigs, sheep, goats, and birds. Extraction solvent, such as a volume of water, was added thereto, stirred for several hours, and then removed to obtain protein. The extract was then filtered.

In this case, water is suitable as the extraction solvent.

Next, the preparation example of the soy extract used for this invention is given.

[Production Example 1]

1 kg of soy sauce, crushed 1kg of pig's soy sauce, 2 liters of water, stirred for 3 hours, extracted, and lactic acid was added to adjust the pH to around 4.5 and heated to a temperature above 80 ° C to denature protein and filtrate with the tissue layer. Filtration was carried out to obtain 2.5 L of the extract. The obtained extract was specific gravity 1.003 to 1.008, pH 4.5 to 5.5, evaporation residue 2.0 g / 100 ml or less, total nitrogen 90 to 150 mg / 100 ml, niproproxide reaction, and diazo reaction were all positive.

[Production Example 2]

20 liters of purified water was added to 10 kg of chicken's soy sauce, and the tissues were crushed by a mixer or the like and stirred and extracted at 80 to 90 ° C. for 3 hours.

Next, the pH was adjusted to 4.5 with 10% sulfuric acid, and the protein and tissue pieces were removed by filtration with a cloth or the like.

In addition, the microparticles were centrifuged or filtered through celite to obtain an extract.

Next, the pH is adjusted to 2.0, and 20 g of one oxidant is slowly added to the heated to 50 ° C and stirred slowly for 2 to 3 hours to precipitate copper salts such as amino acids.

This copper salt is washed several times with cold water, and hydrogen sulfide gas is blown into the suspended water in 5 L of purified water, and copper is precipitated using copper sulfide.

The filtered filtrate is concentrated under reduced pressure until the volume reaches about 1/5 to remove excess hydrogen sulfide.

This extract is usually used as a cosmetic after finally adjusting to 20 liters.

As for the ratio of combining the placental extract and the soy extract, the organ extract 5 to 0.01 (weight) is suitable for the placenta extract 10 (weight).

In addition, the proportion of these active ingredients contained in the cosmetics can be sufficiently effective as placenta extract is 0.1 to 10% (weight) of the total cosmetics, 0.01 to 5% (weight) of the soy extract.

The cosmetics of the present invention are mainly skin cosmetics such as lotion, cream, milky lotion, packs, etc., and the placenta extract and soy extract are added to cosmetic bases and preparations commonly used in these cosmetics to make cosmetics.

For example, in a lotion, a moisturizing agent such as glycerin and propylene glycol, a skin nutrient, etc. are dissolved in purified water, a preservative, a fragrance and the like are dissolved in alcohol, and both are mixed and solubilized at room temperature. ) To place the lotion extract and soy extract extract as the active ingredient of the present invention.

In the cream, hydrophilic components such as glycerin and sorbitan are added to purified water to form an aqueous phase. The oily phase is solid oil such as beeswax, paraffin, microcrystalline wax, ceresin, higher fatty acid, hydrogenated oil, It adjusts by adding oily components, such as a preservative and surfactant, to semi-solid oils, such as waserine, a lanolin, and glyceride, and liquid oils, such as squalane, liquid paraffin, and various ester oils.

Thus, in the production of a general cream in which the oil phase heated to the same temperature is gradually added and emulsified while warming and slowly stirring the obtained aqueous phase to make it a cream, the placenta extract and the soy extract extract which are the active ingredients of the present invention are added to the aqueous phase. Im.

In the emulsion, a moisturizing agent such as glycerin, a pH adjuster of an acid or an alkali is added to the purified water, mixed with heat, ethanol is added to form an aqueous phase, and a solid oil such as beeswax and paraffin, semi-solid oil such as waserine and lanolin and squalane Oily components, such as preservatives and surfactants, are added to the liquid oil such as liquid paraffin, various ester oils, and the like, mixed and heated to form an oil phase portion, and the oil phase portion is added to the water phase portion to pre-emulsify the carboxyvinyl polymer, carboxymethyl cellulose, etc. In the preparation of general emulsions which are uniformly emulsified with a homomixer by adding a protective colloidal agent, the placental extract and soy extract, which are the active ingredients of the present invention, are added to the aqueous phase to make the emulsion.

In the pack, ethanol containing a moisturizing agent such as glycerin, a coating agent such as polyvinyl alcohol, a non-gum, and the like is expanded to purified water, and if necessary, powders such as kaolin, talc and zinc oxide are added to dissolve the fragrance and preservatives. In the manufacture of a general pack kneaded until a paste is added, the placenta extract and the soy extract, which are the active ingredients of the present invention, are added to form a pack.

Next, the Example of this invention is given.

[Example 1]

[Crime]

Soy extract 1.0%

Placental Extract 5.0%

2.09% polyoxyethylene stearin ether

2.91% polyoxyethylene cetyl ether

Beeswax 4.0%

Cetanol 3.0%

Isopropyl palmitate 2.0%

Floating paraffin 15.0%

Polyethylene glycol monostearate 0.5%

Purified water 64.4%

Paraoxymethyl Benzoate 0.1%

[Example 2]

[latex]

Soy extract 2.0%

Placental Extract 4.0%

Self-emulsifying glycerol monostearate 1.11%

Polyoxyethylene Cetyl Ether 1.89%

MC stearic acid 2.0%

Cetanol 1.0%

Isopropyl myristate 2.0%

Purified Water 85.90%

Paraoxy Benzoate 0.1%

A small amount of spices

Example 3

[pack]

Soy extract 0.6%

Placental Extract 6.0%

Ethanol 3.0%

Paraoxymethyl Benzoate 0.1%

Carboxy Vinyl Polymer 1.0%

Calcium Carbonate 0.3%

Titanium Dioxide 0.02%

Purified Water 88.98%

A small amount of spices

Example 4

[toilet water]

Soy extract 3.6%

Placenta Extract 10.0%

Ethanol 10.0%

Paraoxymethyl Benzoate 0.1%

Citric acid 0.2%

A small amount of spices

Purified water 76.7%

The color whitening effect of the combination of placenta extract and soy extract, which are the active ingredients of the present invention, is synergistically superior to the same effect of the individual components alone.

The above effect is made clear by the following experiment.

Experimental Example

1 ml of L-dopa solution (10 mM), 0.9 ml of Mcll Vain's buffer (pH6.8) and 1 ml of sample were added to the test tube and incubated in a constant temperature water bath at 37 ° C. for 10 minutes, followed by tyrosinase solution. 0.1 ml (11,000 G supernatant of B16 mouse Meranooma) was added thereto, stirred well, immediately set in a spectrophotometer, and the absorbance at 475 nm was measured over time.

Samples are placenta extract, soy extract, placenta extract and liquid containing 1/2 weight of soy extract, and water as a control.

In addition, the blocking rate is the rate of inhibition of dopachrome production after 8 minutes when the control is 100.

The above measurement results are shown by the accompanying drawings.

As is apparent from the figure, it can be seen that the combination of the hepatic extract and the placental extract inhibits tyrosinase activity synergistically than that of each alone.

In addition, hepatic extracts and placenta extracts, which are the active ingredients of the present invention, are known to have melanin production inhibitory effects, respectively. As a result, hepatic extract chelates with copper ions that affect the activity of tyrosinase in the early stages of melanogenesis, thereby inhibiting tyrosinase activity and inhibiting melanin production. It showed no chelation, and it was demonstrated that the mechanism of melanin production inhibition of placental extract differs from that of hepatic extract.

As a result, it is thought that the synergistic effect of both is obtained by the melanin production inhibitory effect of a liver extract and a placenta extract.

Claims (3)

Color whitening cosmetics, characterized by containing placental extract and soy extract. The color whitening cosmetic according to claim 1, wherein the placental extract is human placenta extract. The color whitening cosmetic according to claim 1, wherein the soy extract is a soy water extract of mammals and birds.

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