JPS61152614A - Whitening cosmetic - Google Patents

Abstract

PURPOSE:A novel safe whitening cosmetic having improved whitening effect and antisuntan effect, obtained by blending a cosmetic base with a water extract of liver of mammal or bird. CONSTITUTION:For example, liver for mammal such as bovine, swine, sheep, goat, etc., or liver of bird such as chicken, etc., is washed with water and blood is removed from its. The liver is then ground into a gruel state, blended with 2-3 times as much as water, stirred, protein removal operation is carried out, the resultant material is filtered to give an extracted essence. 0.01-10.0wt% of the essence is added to a cosmetic base useful for toilet lotion, cream, milky lotion, pack, etc, or an auxiliary, to give a cosmetic. The extracted essence has improved inhibitory action on melanin dyestuff formation.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to cosmetics, particularly fair skin cosmetics.

[Conventional technology]

Traditionally, skin-lightening cosmetics include hydrogen peroxide, zinc peroxide,
Magnesium peroxide, peroxide) IJum.

Cosmetics containing peroxides such as zinc perborate, magnesium perborate, and sodium perborate, or agents such as blue lead or mercury were used, but the former peroxide is an extremely unstable substance. However, it has been difficult to incorporate into cosmetics, store, etc., and its skin whitening effect has not been satisfactory. In recent years, there are cosmetics that contain vitamin C, cysteine, colloidal sulfur, etc., but they are still not expected to have sufficient effects.

Furthermore, the present inventors have previously discovered cosmetics containing kojic acid (
Japanese Patent Publication No. 56-18569), cosmetics containing derivatives of kojic acid (Japanese Patent Publication No. 56-79616).

JP-A-56-7710), cosmetics containing quercetin fatty acid ester (JP-A-58-131911)
(Japanese Patent Publication No. 55-27883) disclosed a cosmetic containing ergothioneine.

[Problem that the invention seeks to solve]

As a result of research into ingredients that have a safe and effective skin-whitening effect that are different from the active ingredients of known skin-whitening cosmetics, the present invention discovered that mammalian and bird liver water extracts have an excellent melanin pigment production inhibiting effect. The object of the present invention is to provide a novel skin-whitening cosmetic that has excellent skin-whitening effects and sunscreen effects by containing this component, and is also safe.

[Means for solving problems]

The present invention is a skin-lightening cosmetic that has an excellent skin-whitening effect and is highly safe, which contains a water extract of mammalian or bird liver as a cosmetic base.

The active ingredient of the present invention is a water-soluble extract from the liver of a mammal or bird, which can be obtained by a general extraction method. Any bird liver can be used. For extraction, the liver is washed with water to remove blood, then ground into crab-shaped pieces 2~
After adding three times the amount of water and stirring for several hours, a protein removal operation is performed, and an extracted extract can be obtained through a filtration process.

Next, an example of the production of liver extract, which is the active ingredient of the present invention, will be given.

Production Example 1 1 kg of pig liver was ground, water was added from No. 21, and extraction was performed with stirring for 3 hours. Lactic acid was added to adjust the pH to around 4.5, and the temperature was heated to 80°C or higher. The protein was denatured and filtered together with the tissue layer, and the filtrate was further filtered using diatomaceous earth to obtain extract 2.51. The obtained extract has a specific gravity of 1.003-1,008 and a pH of 4.5-5.5.
, evaporation residue below 2.0 g/Loosen, total nitrogen 90-150 mg/100+sj! , nitroprusside reaction, and diazo reaction are both positive.

Production Example 2 Purified water 201 kg was added to 1110 kg of chicken liver, the tissue was crushed using a mixer, etc., and the mixture was stirred and extracted at 80 to 90°C for 3 hours. Next, adjust the pH to 4.5 with 10% sulfuric acid and prepare the protein powder.

Remove tissue pieces by filtering with a cloth or the like. Furthermore, the microparticles are centrifuged or filtered through Celite or the like to obtain an extract.

Next, after adjusting p)I to 2.0 and heating it to around 50°C, gradually add 20 g of cuprous oxide and stir gently for 2 to 3 minutes, and copper salts such as amino acids will precipitate out. So, collect it by centrifuging it. This copper salt is washed several times with cold purified water, and hydrogen sulfide gas is blown into the suspension in the purified water of step 52 to precipitate copper as copper sulfide. Excess hydrogen sulfide can be removed by concentrating the liquid filtered through a filter paper under reduced pressure until the volume reaches 115 degrees. This extract usually has a final content of 20
It is adjusted to 1 and used in cosmetics.

The skin fairing cosmetics of the present invention are mainly skin cosmetics such as lotions, creams, milky lotions, and packs, and 0.0% of the above-mentioned liver extract is added to the cosmetic bases and auxiliaries commonly used in these cosmetics. Add 01 to 10.0% to make cosmetics.

For example, in lotion, moisturizers such as glycerin and propylene glycol, skin nutrients, etc. are dissolved in purified water, preservatives, fragrances, etc. are dissolved in alcohol, and the two are mixed and solubilized at room temperature. In the production of a general lotion, a liver extract, which is the active ingredient of the present invention, is added to the water-soluble part or the alcohol part at a concentration of 0.01 to 10.0% to form a lotion.

In creams, hydrophilic ingredients such as humectants such as glycerin and sorbitol are added to purified water to form the aqueous phase.
The oil phase is beeswax and paraffin.

Solid oils such as microcrystalline wax, ceresin, higher fatty acids, and hydrogenated oils; semi-solid oils such as vaseline, lanolin, and glycerides; liquid oils such as squalane, liquid paraffin, and various ester oils; and oil-based oils such as preservatives and surfactants. Add and adjust ingredients. In the production of general cream, the aqueous phase obtained in this way is heated, and the oil phase heated to the same temperature is gradually added while gently stirring to emulsify the cream. Liver extract, which is the active ingredient of the present invention, is added to the aqueous phase from 0.01 to IO0.
Add to make a cream by adding it to θ%.

For emulsions, use purified water, moisturizers such as glycerin, and acid or alkaline pH 1L! Add preservatives, etc., heat and mix, add ethanol to make the aqueous phase, and add preservatives to solid oils such as beeswax and paraffin, semi-solid oils such as vaseline and lanolin, liquid oils such as squalane, liquid paraffin, and various ester oils. agent.

Add and adjust oily components such as surfactants, mix and heat to form an oil phase, add the oil phase to the aqueous phase to pre-emulsify, and add protective colloids such as carboxyvinyl polymer and carboxymethylcellulose. In the production of a general emulsion, which is uniformly emulsified using a homomixer to form an emulsion, 0.0% of the liver extract, which is the active ingredient of the present invention, is added to the aqueous phase.
01 to 10.0% to the aqueous phase to form a milky lotion.

The pack contains purified water, moisturizers such as glycerin,
Swell by adding a coating agent such as polyvinyl alcohol or vegum, and add kaolin, talc, etc. if necessary.
In the production of general packs, in which powder such as zinc oxide is added, ethanol in which fragrances, preservatives, etc. are dissolved, and kneaded until it becomes a paste, the liver extract, which is the active ingredient of the present invention, is added at a concentration of 0.01 to 10%. Add it to .0% and make it into a pack.

Next, examples of the present invention will be given.

〔Example〕

Example Industrial Lotion Liver Extract (obtained according to 1i1 Preparation Example 2) 5% citric acid 0.4 #Calcium carbonate o, 2 Propylene glycol 9 Ethanol
5 #Wed 79
．． 4 #Fragrance and preservative appropriate amount Example 2 Cold cream liver extract (obtained according to Production Example 2) 1% by weight Beeswax 10 Ceresin
7 Fair-skinned Vaseline
4 “Lanolin
4 Isopropyl myristate 4 Liquid paraffin 44 Squalane
4 Polyoxyethylene cetyl ether 3 Propylene glycol 2 Emulsifier
263 water
14.Fragrance
Appropriate amount Example 3 Punk liver extract (obtained according to Production Example 2) 0.3% by weight Veegum 5 Squalane
2 〃Propylene glycol
5 Zinc oxide 10
〃Kaolin 10〃Ethanol 5〃Fragrances and preservatives
Appropriate amount of purified water 62.
2 [Effects of the Invention] The tyrosinase-inhibiting action of the mammalian and avian liver water extract, which is the active ingredient of the present invention, is as follows.

Experimental example Pine kilvain buffer pH 6,8 (Mcllvain
Buffer)0.9mj! , L-tyrosine 111
Sample 1a+j in 1! After incubating the solution for 3 minutes, 0.1 mJ of pine mushroom tyrosinase was added and further incubated, and dopachrome (maximum absorption wavelength 475 nm) produced every minute was measured.

The samples were 2.5 w/v%, 6.25 w/v%, and 12.5 w/v% of the active ingredient of the present invention obtained in Production Example 2.
A solution containing v% was used, and water was used as a control.

The results of the above measurements are shown in the attached drawings.

As is clear from this figure, the active ingredient of the present invention exhibited an excellent tyrosinase inhibitory effect.

[Brief explanation of drawings]

The figure shows the dopachrome production of the active ingredient of the invention. In the figure, -〇- is a liquid containing 2.5 w/v% of the active ingredient, -×-
is the same 6.25w/V% containing liquid, -1- is the same 12.5w
/V%-containing liquid shows dopachrome production. -〇- indicates dopachrome production in water, which is a control.

Claims (1)

[Claims] 1. A fair-skinned cosmetic characterized by incorporating a mammalian or bird liver water extract into a cosmetic base.