KR870001430B1 - Cosmetic composition for skin - Google Patents

Abstract

A cosmetic compn. is presented. The compn. contg. 3% kojic acid, 10% placenta ext., 10% ethanol, 0.1% p-oxy-benzoate methyl, 0.2% citric acid, trace flavor, and 76.7% distilled water shows an effect for refreshing human skins.

Description

Color cosmetics

The present invention relates to cosmetics, in particular color white cosmetics to enhance the whitening effect of the skin. Various color whitening cosmetics have been provided or researched since ancient times in order to remove spots such as blemishes, freckles, and the like on the skin and to cause whitening effects of the entire skin.

Although peroxides such as hydrogen peroxide, zinc peroxide, magnesium peroxide, sodium peroxide, and zinc perborate have been formulated in cosmetics for a long time, these peroxides are extremely unstable substances and thus have difficulty in preservation or blendability in cosmetics, and their color whitening effect is also sufficient. I could not say.

After that, cosmetics containing vitamin C, cysteine, and colloidal sulfur were used. However, they were not sufficiently satisfied.

Recently, kojic acid obtained by cultivation of bacteria such as koji group (yuk fungus) as a whitening ingredient of these color whitening cosmetics has an effect on skin whitening, and a whitening cosmetic using koji acid Known.

For example, Japanese Patent Application No. 57-18569 and Japanese Patent Application No. 53-3538. In addition, derivatives of kojic acid have also been studied, and cosmetics containing kojic acid derivatives are also known. For example, cosmetics containing Japanese Patent Application Laid-Open Nos. 56-7710, 56-7776, 56-79616, and again a philon compound, a chromone compound, and a flavonol compound are also known.

For example, Japanese Patent Application Laid-Open Nos. 53-3538, 55-92305, 55-111410, 55-111411, 55-143908, 55-157580, 57-14517, 57-35506, Publication 58-131911, etc.

Moreover, the cosmetics which mix | blended placenta extract with cosmetics are also disclosed. For example, JP 35-15399.

The present invention is a cosmetic composition comprising a placenta extract and koji acid or koji acid derivatives in a cosmetic base.

Placenta extract and kojic acid or kojic acid derivatives are color whitening cosmetics with extremely excellent whitening effect by inhibiting them by different mechanisms against tyrosinase involved in the initial stage of melanogenesis.

The placenta extract used in the present invention is an aqueous solution obtained by extracting the water-soluble part through water, and then removing impurities through means such as washing, placenta, crushing and freezing the placenta of an animal such as humans or cows.

In addition, it is commercially available as placenta extract X and is mainly used as a raw material for cosmetics.

These placental extracts may be any of human or animal ones, but human placental extracts are suitable.

Kojic acid derivatives used in the present invention are mono fatty acid esters of kojic acid such as kojic acid monopalmitate, kojic acid monobutyrate, kojic acid monocapurate, kojic acid stearate (disclosed in Japanese Patent Application Laid-Open No. 96-77272), Difatty acid esters of kojic acid such as kojic acid dipalmidate, kojic acid dibutyrate, kojic acid dioleate kojic acid distearate (disclosed in Japanese Patent Application Laid-Open No. 56-7776), other kojic acid monocinnamoate, kojic acid Monobenzoate (disclosed in Japanese Patent Application Laid-Open No. 59-33207) and the like.

The ratio of the above-described placental extract and kojic acid or kojic acid derivative is preferably 3 to 0.1 (weight) of kojic acid or its derivatives relative to placenta extract 10 (weight).

Therefore, the proportion of these active ingredients contained in the cosmetics is sufficiently effective in placenta extract 0.1 to 10% (weight) of the total cosmetics, Koji acid or koji acid derivatives in the order of 0.1 to 3% (weight) relative to the intestinal Can be achieved.

The cosmetics of the present invention are mainly skin cosmetics such as lotion, cream, milky lotion, pack, etc., and the placenta extract and kojic acid or kojic acid derivative are added to cosmetic bases, preparations, etc., which are usually used in each of these cosmetics.

For example, in a lotion, a moisturizing agent such as glycerin and propylene glycol, a skin nutrient, etc. are dissolved in purified water, a preservative, a fragrance, etc. are dissolved in alcohol, and both are mixed and solubilized at room temperature. Placenta extract and kojic acid or kojic acid derivatives, which are the active ingredients of the present invention, are added to make the lotion.

In creams, hydrophilic components such as glycerin and sorbet are added to purified water to form an aqueous phase, and the oily phase is solid oil such as beeswax, paraffin, microcrystalline wax, ceresin, higher fatty acids, and hardened oils. Semi-solid oils, such as petrolatum, lanolin, and glyceride, are adjusted there by adding oily components, such as a preservative and surfactant, to liquid oils, such as squalane, a liquid paraffin, and various ester oils.

In the preparation of a general cream obtained by heating the aqueous phase obtained in this way and warming to a constant temperature with gentle stirring, but gradually adding the oil phase and emulsifying it into a cream, the placenta extract and kojic acid, which are the active ingredients of the present invention, in the aqueous phase portion or its A derivative is added to make a cream.

In the emulsion, a moisturizer such as glycerin or an alkaline pH adjuster is added to the purified water, mixed with heat, ethanol is added to the aqueous phase, and a solid oil such as beeswax and paraffin, semi-solid oil such as petrolatum and lanolin, squalane, liquid paraffin, various Oily components, such as preservatives and surfactants, are added to the liquid oils such as ester oils, mixed and heated to form an oil phase portion, and the oil phase portion is added to the water phase portion for preemulsification to protect carboxyvinyl polymer, carboxymethyl cellulose, and the like. In the preparation of general emulsions in which a colloidal agent is added, which is uniformly emulsified with a homomixer to form an emulsion, placenta extract and kojic acid or a derivative thereof, which are the active ingredients of the present invention, are added to the aqueous phase to form an emulsion.

In the pack, moisturizers such as glycerin, coating agents such as polyvinyl alcohol, bee gum, etc., are added to purified water, and then swelled. If necessary, powders such as kaolin, talc, zinc oxide, and the like are dissolved in fragrances and preservatives. In the manufacture of general packs trained to add ethanol to form a paste, a pack is added by adding placenta extract and kojic acid or kojic acid derivative, which are the active ingredients of the present invention.

The whitening effect of the combination of placenta extract and kojic acid or kojic acid derivatives, which is the active ingredient of the present invention, is synergistically superior to the same effect of the individual components alone.

The above effect is evident by the bleaching test with cultured pigment cells.

[Test Example]

1. Cell used

Mouse Meranomeric B16 Cells (hereinafter B16 Cells)

2. Culture conditions

37 ° C, 5, using Eagle's MEM medium with 10% fetal calf serum, 2.2 g / l sodium hydrogen carbonate and 5 mM N-2-hydroxy ethylpiperadine-N'-ethanesulfonic acid The cells were cultured in a CO ₂ incubator set at% CO ₂ .

3. Test sphere

A group: Koji-san, no placenta extract added,

B group: In the group to which kojic acid was added, 0.1-M for B-I, 0.5-M for B-II, 1.0-M for B-III, 2.0-M for B-IV, and 3.0-M for B-V.

C spheres: 100 ml of placental extracts were lyophilized in the spheres to which the placental extracts were added, and then dissolved in 100 ml of the cell culture solution, and C-Ⅰ bulbs were used for 1/16 of the stock solution, and C-Ⅱ spheres were undiluted solutions. For 1/8, C-III spheres are for 1/4 of the stock solution, C-IV spheres are for half of the stock solution, and C-V spheres are for adding the stock solution.

D sphere: In the combination of Koji-san and placenta extract, the active ingredient of the present invention, D-I sphere is 0.1mM koji acid, combined use for 1/16 of the placenta extract stock solution, D-II sphere 0.5mM placenta extract For 1/8 of the undiluted solution, D-III ball was Cozy III-1.0 mM. The combined use for 1/4 of placenta extract and D-IV were 2.6mM of kojic acid, the combined use for 1/2 of placenta extract and D-V was 3.0mM of koji acid and the combined use of placenta extract.

4. Determination of melanin production inhibitory power

In each test group, B 16 cells were sprinkled with 1.2 × 10 ⁵ cells / dish and incubated for 6 days, and then the grown cells were dispersed with trypsin, collected by centrifugation at 1000 r.pm X 5 min, and the degree of blackening thereof was visually determined.

-: Displays no addition furniture and blackening degree.

±: Displays less blackening degree than no addition.

+: The blackening degree is clearly less than the no addition group.

++: A slightly accepted blackening degree.

+++: White to gray, not recognized as black.

5. Judgment Results

It is shown in the following table.

As apparent from the above results, the active ingredient of the present invention exhibits a melanin-preventing effect more prominent than the test piece of each single component of the present active ingredient, as well as no additives.

In addition, it is known that kojic acid or kojic acid derivatives and placental extracts of the active ingredient of the present invention each have melanin production inhibitory activity alone, but according to the study of the present inventors, in a cell system using B 16 cells used in this test. Based on the analysis of melanin production, kojic acid inhibits tyrosinase activity as a copper ion and chelation on tyrosinase activity involved in the initial stage of melanogenesis, and inhibits melanin production. In addition, it was demonstrated that the placenta extract did not show the chelation of copper ions, and the mechanism of inhibition of melanin production of placental extract was different from that of kojic acid.

As a result, it is thought that synergistic effect of both is obtained by different melanin inhibitory action of kojic acid or its derivatives and placental extract.

EXAMPLE

[Example 1]

<Cream>

Kojisan 1.0%

Placental Extract X 5.0%

2.09% polyoxyethylene stearyl ether

2.91% polyoxyethylene cetyl ether

Beeswax 4.0%

Cetanol 3.0%

Isopropyl Palmitate 2.0%

Liquid paraffin 15.0%

Polyethylene Glycol Monostearate 0.5%

Purified water 64.4%

Paraoxybenzoatemethyl 0.1%

[Example 2]

<Latex>

Kojisan 2.0%

Placenta Extract X 4.0%

Self-emulsifying glycerol monostearate 1.11%

Polyoxyethylene Cetyl Ether 1.89%

MC stearic acid 2.0%

Cetanol 1.0%

Isopropyl millistate 2.0%

Purified Water 85.90%

Paraoxybenzoic acid 0.1%

A small amount of spices

Example 3

<Pack>

Kojisan 0.5%

Placenta extract extract 6, 0%

Ethanol 3.0%

Paraoxybenzoatemethyl 0.1%

Carboxy Vinyl Polymer 1.0%

Calcium Carbonate 0.3%

Titanium Dioxide 0.02%

Purified Water 89.08%

A small amount of spices

Example 4

<Cosmetics>

Kojisan 3.0%

Placenta Extract 10.0%

Ethanol 10.0%

Paraoxybenzoatemethyl 0.1%

Citric acid 0.2%

A small amount of spices

Purified water 76.7%

Claims (2)

A color cosmetic comprising a placenta extract and kojic acid or kojic acid derivative. The color cosmetic according to claim 1, wherein the placenta extract is human placenta extract.