KR910007883A - 퀴놀린 유도체, 그의 제조방법 및 용도 - Google Patents

퀴놀린 유도체, 그의 제조방법 및 용도 Download PDF

Info

Publication number
KR910007883A
KR910007883A KR1019900015908A KR900015908A KR910007883A KR 910007883 A KR910007883 A KR 910007883A KR 1019900015908 A KR1019900015908 A KR 1019900015908A KR 900015908 A KR900015908 A KR 900015908A KR 910007883 A KR910007883 A KR 910007883A
Authority
KR
South Korea
Prior art keywords
lower alkyl
formula
salt
quinolyl
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1019900015908A
Other languages
English (en)
Korean (ko)
Inventor
깐지 메구로
히또시 이께다
Original Assignee
우메모또 요시마사
다께다야꾸힝고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우메모또 요시마사, 다께다야꾸힝고오교 가부시끼가이샤 filed Critical 우메모또 요시마사
Publication of KR910007883A publication Critical patent/KR910007883A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Holo Graphy (AREA)
  • Detergent Compositions (AREA)
  • Measurement Of Radiation (AREA)
  • Quinoline Compounds (AREA)
KR1019900015908A 1989-10-06 1990-10-06 퀴놀린 유도체, 그의 제조방법 및 용도 Abandoned KR910007883A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP262782/1989 1989-10-06
JP26278289 1989-10-06
JP322290/1989 1989-12-11
JP32229089 1989-12-11

Publications (1)

Publication Number Publication Date
KR910007883A true KR910007883A (ko) 1991-05-30

Family

ID=26545706

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900015908A Abandoned KR910007883A (ko) 1989-10-06 1990-10-06 퀴놀린 유도체, 그의 제조방법 및 용도

Country Status (17)

Country Link
US (1) US5223513A (enExample)
EP (1) EP0421456B1 (enExample)
KR (1) KR910007883A (enExample)
CN (1) CN1050715A (enExample)
AT (1) ATE116301T1 (enExample)
AU (1) AU629048B2 (enExample)
CA (1) CA2026890C (enExample)
DE (1) DE69015541T2 (enExample)
FI (1) FI904915A7 (enExample)
HU (1) HUT55364A (enExample)
IE (1) IE903454A1 (enExample)
IL (1) IL95839A (enExample)
NO (1) NO904300L (enExample)
NZ (1) NZ235582A (enExample)
PT (1) PT95515A (enExample)
RU (1) RU2001910C1 (enExample)
TW (1) TW205037B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03181465A (ja) * 1989-12-11 1991-08-07 Takeda Chem Ind Ltd キノリン誘導体
FI934710L (fi) * 1991-04-26 1993-10-25 Pfizer 4-aryl-3-(heteroarylureido)kinolinderivat
JP2668163B2 (ja) * 1992-01-23 1997-10-27 ファイザー インク． コレステロール血症および抗アテローム動脈硬化症薬としての４−アリール−３−（ヘテロアリールウレイド）−１，２−ジヒドロ−２−オキソ−キノリン誘導体
TW241258B (enExample) * 1992-04-15 1995-02-21 Takeda Pharm Industry Co Ltd
WO1993024458A1 (en) * 1992-05-28 1993-12-09 Pfizer Inc. New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat)
ATE161530T1 (de) * 1992-09-04 1998-01-15 Takeda Chemical Industries Ltd Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
TW263498B (enExample) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
US5843957A (en) * 1995-05-19 1998-12-01 Sumitomo Pharmaceuticals Company, Ltd. Naphthyridine derivatives
WO1999009983A1 (en) * 1997-08-28 1999-03-04 Bristol-Myers Squibb Company 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
AU2547399A (en) 1998-02-25 1999-09-15 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for producing the same
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
JP2002531549A (ja) * 1998-12-04 2002-09-24 ブリストル−マイヤーズ スクイブ カンパニー カリウムチャネル・モジュレーターとしての３−置換−４−アリールキノリン−２−オン誘導体
EE200200429A (et) 2000-02-02 2003-12-15 Warner-Lambert Company Kolesteroolestri ja vahaestri sünteesi duaalsed inhibiitorid rasunäärme häirete jaoks
EP1375487B1 (en) * 2001-03-02 2011-08-24 Sumitomo Chemical Company, Limited Process for producing quinoline-3-carboxylic acid compounds
DK1383734T3 (da) * 2001-04-30 2006-05-15 Pfizer Prod Inc Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater
EP1667973B1 (en) * 2003-09-23 2013-12-04 Merck Sharp & Dohme Corp. Quinoline potassium channel inhibitors
BR112014010644A2 (pt) * 2011-11-04 2017-04-25 Hoffmann La Roche novos derivados de aril-quinolina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216878B (de) * 1963-04-02 1966-05-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
NO133758C (enExample) * 1970-04-04 1976-06-23 Takeda Chemical Industries Ltd
JPS555502B1 (enExample) * 1971-07-31 1980-02-07
US4530931A (en) * 1983-01-03 1985-07-23 Usv Pharmaceutical Corp. 8-Quinoline carbanilates for the inhibition of lipolysis
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use

Also Published As

Publication number Publication date
US5223513A (en) 1993-06-29
DE69015541D1 (de) 1995-02-09
AU6370790A (en) 1991-04-11
PT95515A (pt) 1991-08-14
HU906360D0 (en) 1991-04-29
EP0421456A2 (en) 1991-04-10
NO904300L (no) 1991-04-08
ATE116301T1 (de) 1995-01-15
CN1050715A (zh) 1991-04-17
IL95839A (en) 1995-03-15
JPH03223254A (ja) 1991-10-02
FI904915A7 (fi) 1991-04-07
CA2026890C (en) 2001-09-18
EP0421456A3 (en) 1991-05-29
AU629048B2 (en) 1992-09-24
TW205037B (enExample) 1993-05-01
IL95839A0 (en) 1991-06-30
DE69015541T2 (de) 1995-06-01
NO904300D0 (no) 1990-10-03
EP0421456B1 (en) 1994-12-28
CA2026890A1 (en) 1991-04-07
IE903454A1 (en) 1991-04-10
NZ235582A (en) 1992-03-26
FI904915A0 (fi) 1990-10-05
RU2001910C1 (ru) 1993-10-30
HUT55364A (en) 1991-05-28

Similar Documents

Publication Publication Date Title
KR910007883A (ko) 퀴놀린 유도체, 그의 제조방법 및 용도
RU2309951C2 (ru) Производные никотинамида, способы их получения, фармацевтическая композиция на их основе и применение
RU92004336A (ru) Водорастворимые производные камптотецина, способ их получения, фармацевтическая композиция, способ ингибирования энзима топоизомеразы, промежуточные продукты
DE69033915D1 (de) Xanthinderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Anwendung
EP0242789A3 (en) Novel quinoline derivates and processes for preparation thereof
CA2280753A1 (en) 1,4-substituted cyclic amine derivatives
CA2037630A1 (en) Nitrogen-containing heterocylic compounds, their production and use
CA2160444A1 (en) Aroyl-piperdine derivatives
HUP0001446A2 (hu) HIV reverz transzkriptáz inhibitor hatású 4,4-diszubsztituált-3,4-dihidro-2(1H)-kinazolinon-származékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
NO940737D0 (no) Antidepressive midler
ATE152719T1 (de) Chinolylbenzofuran derivate als leukotrien- antagonisten
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
IE41539L (en) Chroman derivatives.
EP0353955A3 (en) Novel compounds
RU93004675A (ru) 1,2,4-оксадиазолил-феноксиалкилизоксазолы, их применение в качестве противовирусных агентов, фармацевтическая композиция
DE3853577D1 (de) Benzyliden-Malononitril-Derivate zur Hemmung von proliferativen Prozessen in Säugetierzellen.
EP0358903A3 (en) Indazole-3-carboxylic acid derivatives
MXPA02006329A (es) 8-arilquinolinas sustituidas que son inhibidores de fosfodiesterasa-4.
DE3779825D1 (de) Derivate von benzhydryloxyaethylpiperazinen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES534505A0 (es) Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina
ES8500247A1 (es) Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina.
DE68913365D1 (de) 4-Amino-3-carboxynaphthyridin-Derivate, ihre Herstellung und pharmazeutische Zusammensetzungen.
NO890440D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
HUP9904594A2 (hu) Piperazinoszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
KR970703301A (ko) 신규 디아미노메틸리덴 유도체(novel diamincmethylidene derivative)

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PC1902 Submission of document of abandonment before decision of registration

St.27 status event code: N-1-6-B10-B11-nap-PC1902

SUBM Surrender of laid-open application requested
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000