KR910002844A - 시스 3-아미노-4-[2-(2-푸릴)에트-1-일]-1- 메톡시카보닐 메틸-아제티딘-2-온의 분할방법 - Google Patents

시스 3-아미노-4-[2-(2-푸릴)에트-1-일]-1- 메톡시카보닐 메틸-아제티딘-2-온의 분할방법 Download PDF

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Publication number
KR910002844A
KR910002844A KR1019900011531A KR900011531A KR910002844A KR 910002844 A KR910002844 A KR 910002844A KR 1019900011531 A KR1019900011531 A KR 1019900011531A KR 900011531 A KR900011531 A KR 900011531A KR 910002844 A KR910002844 A KR 910002844A
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South Korea
Prior art keywords
azetidin
eth
furyl
amino
cis
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KR1019900011531A
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English (en)
Inventor
글레이스비 라이트 이안
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일라이 릴리 앤드 캄파니
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Application filed by 일라이 릴리 앤드 캄파니 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR910002844A publication Critical patent/KR910002844A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

시스 3-아미노-4-[2-(2-푸릴)에트-1-일]-1-메톡시카보닐 메틸-아제티딘-2-온의 분할방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. (a)시스 알파알파/베타베타 라세미체의 극성 유기 용액을 적어도 약 0.5몰당량의 광학적으로 활성인 타르타르산과 접촉시키는 단계, (b)상기 용액을 시스 베타베타-3-아미노-4-[2-(2-푸릴)에트-1-일]-1-메톡시카보닐메틸-1-아제티딘-2-온의 L-(+)-타르타르산 염 또는 시스시스 알파알파-3-아미노-4-[2-(2-푸릴)에트-1-일]-1-메톡시카보닐메틸-1-아제티딘-2-온의 D-(-)-타르타르산 염으로 시딩(seeding)하는 단계 및 (c)상기와 같이 형성된 불용성 염을 분리하는 단계를 포함하는, 시스 알파알파/베타베타-3-아미노-4-[2-(2-푸릴)에트-1-일]-1-메톡시카보닐메틸-아제티딘-2-온을 그의 성분에 에난티오머들로 분할시키는 방법.
  2. 제1항에 있어서, 사용된 극성 유기용매가 아세토나이트릴인 방법.
  3. 제1항 또는 제2항에 있어서, 사용된 극성 유기용매가 1내지 4%의 물을 함유하는 아세토나이트릴인 방법.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, L-(+)-타르타르산을 분할시약(resolving agent)으로서 사용하는 방법.
  5. 제1항 내지 제3항중 어느 한 항에 있어서, D-(-)-타르타르산을 분할시약으로서 사용하는 방법.
  6. 시스 베타베타-3-아미노-4-[2-(2-푸릴)에트-1-일]-1-메톡시카보닐메틸-아제티딘-2-온의 L-(+)-타르타르산 염.
  7. 시스 알파알파-3-아미노-4-[2-(2-푸릴)에트-1-일]-1-메톡시카보닐메틸-아제티딘-2-온의 D-(+)-타르타르산 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900011531A 1989-07-31 1990-07-28 시스 3-아미노-4-[2-(2-푸릴)에트-1-일]-1- 메톡시카보닐 메틸-아제티딘-2-온의 분할방법 KR910002844A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US386664 1989-07-31
US07/386,664 US4923983A (en) 1989-07-31 1989-07-31 Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one

Publications (1)

Publication Number Publication Date
KR910002844A true KR910002844A (ko) 1991-02-26

Family

ID=23526531

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900011531A KR910002844A (ko) 1989-07-31 1990-07-28 시스 3-아미노-4-[2-(2-푸릴)에트-1-일]-1- 메톡시카보닐 메틸-아제티딘-2-온의 분할방법

Country Status (8)

Country Link
US (1) US4923983A (ko)
EP (1) EP0416736A3 (ko)
JP (1) JPH0366686A (ko)
KR (1) KR910002844A (ko)
CA (1) CA2022021A1 (ko)
HU (1) HUT58728A (ko)
IE (1) IE902755A1 (ko)
IL (1) IL95200A0 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923983A (en) * 1989-07-31 1990-05-08 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one
US5030725A (en) * 1990-02-06 1991-07-09 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one using (-)-DAG
US5142038A (en) * 1991-07-23 1992-08-25 Eli Lilly And Company Process of enantiomeric separation of carbacephem intermediates
SE9601600D0 (sv) * 1996-04-26 1996-04-26 Astra Ab Improved process
AU1037701A (en) * 1999-10-20 2001-04-30 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
EP2057145B1 (en) * 2006-07-20 2012-08-22 Abbott Laboratories Synthesis of (2s,5r)-5-ethynyl-1-{n-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile
EP1943248A2 (en) * 2006-08-03 2008-07-16 Teva Pharmaceutical Industries Ltd. Solifenacin base forms and preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116332A (en) * 1958-10-17 1963-12-31 Du Pont Resolution of racemic aminoisopropanol
US4923983A (en) * 1989-07-31 1990-05-08 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one

Also Published As

Publication number Publication date
IE902755A1 (en) 1991-02-27
IL95200A0 (en) 1991-06-10
HUT58728A (en) 1992-03-30
US4923983A (en) 1990-05-08
EP0416736A3 (en) 1991-11-06
CA2022021A1 (en) 1991-02-01
HU904658D0 (en) 1991-01-28
EP0416736A2 (en) 1991-03-13
JPH0366686A (ja) 1991-03-22

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