KR900701813A - 뉴클레오시드, 폴리뉴클레오티드 티오포스포르아미다이트 및 포스포로디티오에이트 화합물 및 그 제조방법 - Google Patents

뉴클레오시드, 폴리뉴클레오티드 티오포스포르아미다이트 및 포스포로디티오에이트 화합물 및 그 제조방법

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Publication number
KR900701813A
KR900701813A KR1019900700156A KR900700156A KR900701813A KR 900701813 A KR900701813 A KR 900701813A KR 1019900700156 A KR1019900700156 A KR 1019900700156A KR 900700156 A KR900700156 A KR 900700156A KR 900701813 A KR900701813 A KR 900701813A
Authority
KR
South Korea
Prior art keywords
nucleoside
oligonucleotide
substituted
compound
sulfur
Prior art date
Application number
KR1019900700156A
Other languages
English (en)
Korean (ko)
Inventor
마빈 카루터스
볼프강 브릴
존 닐센
Original Assignee
원본미기재
유니버시티 페이턴트 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 유니버시티 페이턴트 인코포레이티드 filed Critical 원본미기재
Publication of KR900701813A publication Critical patent/KR900701813A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019900700156A 1988-05-26 1989-05-25 뉴클레오시드, 폴리뉴클레오티드 티오포스포르아미다이트 및 포스포로디티오에이트 화합물 및 그 제조방법 KR900701813A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19888688A 1988-05-26 1988-05-26
US198,886 1988-05-26
US31401189A 1989-02-22 1989-02-22
US314,011 1989-05-22
PCT/US1989/002293 WO1989011486A1 (en) 1988-05-26 1989-05-25 Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes

Publications (1)

Publication Number Publication Date
KR900701813A true KR900701813A (ko) 1990-12-04

Family

ID=26894243

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900700156A KR900701813A (ko) 1988-05-26 1989-05-25 뉴클레오시드, 폴리뉴클레오티드 티오포스포르아미다이트 및 포스포로디티오에이트 화합물 및 그 제조방법

Country Status (7)

Country Link
EP (1) EP0378615A4 (xx)
JP (1) JPH03501128A (xx)
KR (1) KR900701813A (xx)
AU (1) AU626305B2 (xx)
ES (1) ES2015665A6 (xx)
IL (1) IL90359A0 (xx)
WO (1) WO1989011486A1 (xx)

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* Cited by examiner, † Cited by third party
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US5194599A (en) * 1988-09-23 1993-03-16 Gilead Sciences, Inc. Hydrogen phosphonodithioate compositions
US6756496B1 (en) 1988-09-23 2004-06-29 Isis Pharmaceuticals, Inc. Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues
US5470967A (en) * 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
US5151510A (en) * 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
EP0463712A3 (en) 1990-06-27 1992-04-08 University Patents, Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
US5602240A (en) * 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5610289A (en) 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5623070A (en) * 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
EP0549686A4 (en) * 1990-09-20 1995-01-18 Gilead Sciences Inc Modified internucleoside linkages
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
CA2080305A1 (en) 1991-10-11 1993-04-12 Linda M. Western Method for producing a polynucleotide for use in single primer amplification and phosphorothioate-containing oligonucleotides as primers in nucleic acid amplification
AU3920293A (en) * 1993-03-16 1994-10-11 Board Of Regents Of The University Of Nebraska, The Novel metal binding agents, and methods and compositions for their use to treat metal toxicity
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
US6001982A (en) 1993-07-29 1999-12-14 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
WO1997036005A1 (en) * 1996-03-26 1997-10-02 Lynx Therapeutics, Inc. Oligonucleotide treatments and compositions for human melanoma
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
EP2915815B1 (en) 2012-10-31 2018-01-17 Takeda Pharmaceutical Company Limited New modified nucleic acid
JOP20170192A1 (ar) 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co داي نوكليوتيد حلقي
EP3643706B1 (en) 2017-06-16 2023-11-15 Eisai R&D Management Co., Ltd. Modified nucleic acid monomers and oligonucleic acid analogues, with high biological stability and target gene silencing activity, for use in therapy and diagnosis of cancer and viral diseases
JP7476101B2 (ja) * 2017-12-22 2024-04-30 ロシュ イノベーション センター コペンハーゲン エーエス ホスホロジチオアートヌクレオシド間結合を含むギャップマーオリゴヌクレオチド
TW201929870A (zh) * 2017-12-22 2019-08-01 丹麥商羅氏創新中心哥本哈根有限公司 包含二硫代磷酸酯核苷間連結之寡核苷酸
CN111039977B (zh) * 2019-12-31 2022-11-08 广州同隽医药科技有限公司 一种亚磷酰化试剂及其在寡核苷酸合成中的应用
JP2023553069A (ja) * 2020-12-08 2023-12-20 エフ． ホフマン－ラ ロシュ アーゲー ホスホロジチオエートオリゴヌクレオチドの新規合成

Family Cites Families (11)

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US808708A (en) * 1905-09-20 1906-01-02 Earnest R Wingate Clamp.
US3451997A (en) * 1965-11-30 1969-06-24 Kyowa Hakko Kogyo Kk Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives
DE2122529A1 (de) * 1971-05-06 1972-12-14 Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen Thiophosphatanaloge der Nucleosid di und tnphosphate sowie Verfahren zu ihrer Herstellung
US3853844A (en) * 1972-08-04 1974-12-10 R Robins Nucleoside 3{40 ,5{40 ,-cyclic phosphorothioates
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4373071A (en) * 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4728730A (en) * 1984-09-12 1988-03-01 Wisconsin Alumini Research Foundation Synthesis of nucleoside thiophosphoanhydrides
JPS6251695A (ja) * 1985-08-29 1987-03-06 Yuki Gosei Yakuhin Kogyo Kk ホスホロアミダイト類の合成法
WO1990012022A1 (en) * 1989-03-31 1990-10-18 University Patents, Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
WO1991004983A1 (en) * 1989-10-05 1991-04-18 University Patents, Inc. Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes

Also Published As

Publication number Publication date
WO1989011486A1 (en) 1989-11-30
AU3739289A (en) 1989-12-12
EP0378615A1 (en) 1990-07-25
AU626305B2 (en) 1992-07-30
JPH03501128A (ja) 1991-03-14
ES2015665A6 (es) 1990-09-01
IL90359A0 (en) 1989-12-15
EP0378615A4 (en) 1992-04-08

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