KR900700093A - 수용성 이부프로펜 제제 및 그 제조방법 - Google Patents
수용성 이부프로펜 제제 및 그 제조방법Info
- Publication number
- KR900700093A KR900700093A KR1019890702189A KR890702189A KR900700093A KR 900700093 A KR900700093 A KR 900700093A KR 1019890702189 A KR1019890702189 A KR 1019890702189A KR 890702189 A KR890702189 A KR 890702189A KR 900700093 A KR900700093 A KR 900700093A
- Authority
- KR
- South Korea
- Prior art keywords
- ibuprofen
- alkali metal
- aqueous solvent
- formulation
- moles
- Prior art date
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title claims 24
- 229960001680 ibuprofen Drugs 0.000 title claims 24
- 239000000203 mixture Substances 0.000 title claims 9
- 238000009472 formulation Methods 0.000 title claims 8
- 238000004519 manufacturing process Methods 0.000 title claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 18
- -1 alkali metal salt Chemical class 0.000 claims 17
- 239000003125 aqueous solvent Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 이부프로펜의 알카리금속염을 함유하는 물질의 고체결정질 제제.
- 제1항에 있어서, 상기 이부프로펜의 알카리금속염이 이부프로펜의 칼륨염인 제제.
- 제1항에 있어서, 상기 이부프로펜의 알카리금속염이 이부프로펜의 나트륨염인 제제.
- 소정량의 알카리금속중탄산염을 수성용매에 용해시키는 단계, 및 소정량의 이부프로펜 제제를 수성용매에 용해시키는 단계로 구성되는 이부프로펜의 알카리금속염의 제조방법.
- 제4항에 있어서, 상기 수성용매로부터 고체알카리금속 이부프로펜을 추출하는 단계를 부가로 포함하는 방법.
- 제4항에 있어서, 상기 알카리금속 중탄산염이 중탄산칼륨으로 구성되고 상기 이부프로펜의 알카리금속염이 이부프로펜의 칼륨염으로 구성되는 방법.
- 제4항에 있어서, 상기 알카리금속 중탄산염이 중탄산나트륨으로 구성되고 상기 이부프로펜의 알카리금속염의 이부프로펜의 나트륨염으로 구성되는 방법.
- 제4항에 있어서, 소정량의 알카리금속 중탄산염을 수성용매에 용해시키는 단계가 소정몰수의 알카리금속 중탄산염을 수성용매에 용해시키는 단계로 구성되고, 소정량의 이부프로펜 제제를 수성용매에 용해시키는 단계가 소정몰수의 이부프로펜제제를 수성용매에 용해시키는 단계로 구성되며, 상기 알카리금속 중탄산염의 소정몰수가 적어도 이부프로펜제제의 소정몰수만큼 큰 방법.
- 제8항에 있어서, 상기 이부프로펜 제제가 이부프로펜의 알카리금속염으로 완전하고 효율적으로 전환될 수 있도록 상기 알카리 금속중탄산염의 소정몰수가 이부프로펜제제의 소정몰수보다 큰 방법.
- 경구투여시에 이부프로펜의 향이 없고 감소된 소성감을 가지는 액체 이부프로펜제제에 있어서, 수성용매에 용해된 소정량의 알카리금속 중탄산제제, 및 수성용매에 용해된 소정량의 이부프로펜 제제로 구성되고, 상기 수성용매에 용해된 알카리금속 중탄산염의 몰수가 적어도 상기 수성용매에 용해된 이부프로펜제제의 몰수만큼 큰 제제.
- 제10항에 있어서, 상기 수성용매에 용해된 알카리금속중탄산염제제의 몰수와 상기 수성용매에 용해된 이부프로펜 제제의 몰수와의 비가 상기 액체조성물을 경구투여할 때 이부프로펜의 향이 거의 제거되고 소성감이 거의 감소되는 정도인 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/173,299 US4859704A (en) | 1987-10-15 | 1988-03-25 | Water soluble ibuprofen compositions and methods of making them |
US173,299 | 1988-03-25 | ||
PCT/US1989/001203 WO1989009053A1 (en) | 1988-03-25 | 1989-03-23 | Water soluble ibuprofen compositions and methods of making them |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900700093A true KR900700093A (ko) | 1990-08-11 |
Family
ID=22631385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890702189A KR900700093A (ko) | 1988-03-25 | 1989-03-23 | 수용성 이부프로펜 제제 및 그 제조방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US4859704A (ko) |
EP (1) | EP0406307A4 (ko) |
JP (1) | JPH03502800A (ko) |
KR (1) | KR900700093A (ko) |
AU (1) | AU3359389A (ko) |
IL (1) | IL89702A0 (ko) |
WO (1) | WO1989009053A1 (ko) |
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DE4140184C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Flurbiprofen enthaltendes Arzneimittel |
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WO2011001228A1 (en) * | 2008-08-14 | 2011-01-06 | Shasun Chemicals And Drugs Limited | Aryl alkyl carboxylic acid salts, process for preparation and dosage forms |
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KR20140014350A (ko) | 2009-03-12 | 2014-02-06 | 큠버랜드 파마슈티컬즈 인코포레이티드 | 정맥 내 투여용 이부프로펜의 투여 |
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-
1988
- 1988-03-25 US US07/173,299 patent/US4859704A/en not_active Expired - Lifetime
-
1989
- 1989-03-21 IL IL89702A patent/IL89702A0/xx unknown
- 1989-03-23 JP JP1503916A patent/JPH03502800A/ja active Pending
- 1989-03-23 KR KR1019890702189A patent/KR900700093A/ko not_active Application Discontinuation
- 1989-03-23 AU AU33593/89A patent/AU3359389A/en not_active Abandoned
- 1989-03-23 WO PCT/US1989/001203 patent/WO1989009053A1/en not_active Application Discontinuation
- 1989-03-23 EP EP19890904398 patent/EP0406307A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU3359389A (en) | 1989-10-16 |
EP0406307A1 (en) | 1991-01-09 |
EP0406307A4 (en) | 1991-03-20 |
JPH03502800A (ja) | 1991-06-27 |
US4859704A (en) | 1989-08-22 |
WO1989009053A1 (en) | 1989-10-05 |
IL89702A0 (en) | 1989-09-28 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |