KR900016250A - 1α, 25-디하이드록시비타민 D₂및 이의 24-에피머의 제조방법 - Google Patents
1α, 25-디하이드록시비타민 D₂및 이의 24-에피머의 제조방법 Download PDFInfo
- Publication number
- KR900016250A KR900016250A KR1019890004729A KR890004729A KR900016250A KR 900016250 A KR900016250 A KR 900016250A KR 1019890004729 A KR1019890004729 A KR 1019890004729A KR 890004729 A KR890004729 A KR 890004729A KR 900016250 A KR900016250 A KR 900016250A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- epimer
- compound
- triol
- ergostatriene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 일반식(Ⅰ)의 (22E)-5,7,22-에르고스타트리엔-2α,3β,25-트리올 또는 이의 24-에피머를 조사하고, 이어서 이성체화함을 포함하여, 일반식(Ⅱ)의 1α,25-디하이드록시비타민 D2또는 이의 24-에피머를 제조하는 방법.상기식에서, R1이 CH3인 경우, R2는 H(24 S 형태)이고, R2가 CH3인 경우, R1은 H(24 R 형태)이다.
- 일반식(Ⅰ)의 (22E)-5,7,22-에르고스타트리엔-1α, 3β, 25-트리올 또는 이의 24-에피머.상기식에서, R1이 CH3인 경우, R2는 H(24 S 형태)이고, R2가 CH3인 경우, R1은 H(24 R 형태)이다.
- (22E)-5,7,22-에르고스타트리엔-1α, 3β-디올디아세테이트를 4-페닐-1,2,4-트리아졸린-3,5-디온과 반응시켜 일반식(Ⅳ)의 디일스-알더 부가 생성물을 형성하고, 당해 디일스-알더 부가 생성물(Ⅳ)를 오존으로 산화시키며 이어서 환원 후 처리하면 일반식(Ⅴ)의 알데하이드 화합물을 생성시키고, 수득한 알데하이드 화합물(Ⅴ)를 일반식(A)의 설폰 화합물과 반응시키며 이어서 환원제거하여 일반식(Ⅶ)의 (22E)-올레핀 화합물을 수득하고, 수득한 (22E)-올레핀 화합물(Ⅶ)의 25-하이드록시 그룹을 보호하는 테트라하이드로피라닐 그룹을 제거하여 일반식(Ⅷ)의 트리올 화합물을 생성시키고, 수득한 트리올 화합물(Ⅷ)을 환원시켜 5,7-디엔중의 보호그룹을 제거함을 포함하여 일반식(Ⅰ)의 (22E)-5,7,22-에르고스타트리엔-1α, 3β, 25-트리올 또는 이의 24-에피머를 제조하는 방법.상기식에서, R1이 CH3인 경우, R2는 H(24 S 형태)이고, R2가 CH3인 경우, R1은 H(24 R 형태)이다.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP87,269/88 | 1988-04-11 | ||
JP8726988 | 1988-04-11 | ||
JP63-87269 | 1988-04-11 | ||
JP329,178/88 | 1988-12-28 | ||
JP63329178A JP2608322B2 (ja) | 1988-04-11 | 1988-12-28 | 1α,25‐ジヒドロキシビタミンD▲下2▼類の製造法 |
JP63-329178 | 1988-12-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900016250A true KR900016250A (ko) | 1990-11-13 |
KR970007949B1 KR970007949B1 (ko) | 1997-05-19 |
Family
ID=26428559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890004729A KR970007949B1 (ko) | 1988-04-11 | 1989-04-11 | 1α,25-디하이드록시비타민 D₂및 이의 24-에피머의 제조방법 |
Country Status (5)
Country | Link |
---|---|
US (1) | US5087709A (ko) |
EP (1) | EP0337305B1 (ko) |
JP (1) | JP2608322B2 (ko) |
KR (1) | KR970007949B1 (ko) |
DE (1) | DE68919887T2 (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2645130B2 (ja) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
IN171449B (ko) * | 1990-02-14 | 1992-10-17 | Wisconsin Alumni Res Found | |
KR100257445B1 (ko) * | 1992-04-15 | 2000-08-01 | 에드워드 이. 데이비스 | 스테롤 혼합물로부터 5,7-디엔작용기를 함유한 스테로이드를 분리하는 방법 |
US5194431A (en) * | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
ES2575003T3 (es) * | 2008-03-12 | 2016-06-23 | Opko Ireland Global Holdings, Limited | 1,25-Dihidroxivitamina D2 estabilizada y método de preparación de la misma |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3070985D1 (en) * | 1979-10-23 | 1985-09-19 | Teijin Ltd | Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained |
JPS60501261A (ja) * | 1983-05-09 | 1985-08-08 | ウイスコンシン アラムナイ リサ−チ フォンデ−ション | 1α,25―ジヒドロキシル化ビタミンD↓2化合物及びその製造方法 |
US4769181A (en) * | 1983-11-07 | 1988-09-06 | Wisconsin Alumni Research Foundation | 1,25-dihydroxyvitamin D2 compounds |
US4717721A (en) * | 1985-05-30 | 1988-01-05 | Howard W. Bremer | Sidechain homo-vitamin D compounds with preferential anti-cancer activity |
-
1988
- 1988-12-28 JP JP63329178A patent/JP2608322B2/ja not_active Expired - Fee Related
-
1989
- 1989-04-04 US US07/333,547 patent/US5087709A/en not_active Expired - Fee Related
- 1989-04-07 EP EP89106124A patent/EP0337305B1/en not_active Expired - Lifetime
- 1989-04-07 DE DE68919887T patent/DE68919887T2/de not_active Expired - Fee Related
- 1989-04-11 KR KR1019890004729A patent/KR970007949B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE68919887D1 (de) | 1995-01-26 |
DE68919887T2 (de) | 1995-04-27 |
JP2608322B2 (ja) | 1997-05-07 |
JPH0236166A (ja) | 1990-02-06 |
KR970007949B1 (ko) | 1997-05-19 |
US5087709A (en) | 1992-02-11 |
EP0337305A1 (en) | 1989-10-18 |
EP0337305B1 (en) | 1994-12-14 |
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