KR900006854B1 - 미토마이신 유사체 및 그의 제조방법 - Google Patents

미토마이신 유사체 및 그의 제조방법 Download PDF

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Publication number
KR900006854B1
KR900006854B1 KR1019840000574A KR840000574A KR900006854B1 KR 900006854 B1 KR900006854 B1 KR 900006854B1 KR 1019840000574 A KR1019840000574 A KR 1019840000574A KR 840000574 A KR840000574 A KR 840000574A KR 900006854 B1 KR900006854 B1 KR 900006854B1
Authority
KR
South Korea
Prior art keywords
methyl
methoxy
pyrrolo
indole
hexahydro
Prior art date
Application number
KR1019840000574A
Other languages
English (en)
Korean (ko)
Other versions
KR840007726A (ko
Inventor
에이. 레머스 윌리암
Original Assignee
유니버시티 페이턴츠, 인코포레이티드
에이.시드니 알퍼트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 유니버시티 페이턴츠, 인코포레이티드, 에이.시드니 알퍼트 filed Critical 유니버시티 페이턴츠, 인코포레이티드
Publication of KR840007726A publication Critical patent/KR840007726A/ko
Application granted granted Critical
Publication of KR900006854B1 publication Critical patent/KR900006854B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019840000574A 1983-02-07 1984-02-07 미토마이신 유사체 및 그의 제조방법 KR900006854B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46461283A 1983-02-07 1983-02-07
US464612 1983-02-07
US464,612 1983-02-07

Publications (2)

Publication Number Publication Date
KR840007726A KR840007726A (ko) 1984-12-10
KR900006854B1 true KR900006854B1 (ko) 1990-09-22

Family

ID=23844605

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000574A KR900006854B1 (ko) 1983-02-07 1984-02-07 미토마이신 유사체 및 그의 제조방법

Country Status (29)

Country Link
JP (1) JPS59152384A (da)
KR (1) KR900006854B1 (da)
AT (1) AT385509B (da)
AU (1) AU571193B2 (da)
BE (1) BE898856A (da)
CA (1) CA1252789A (da)
CH (1) CH658658A5 (da)
DD (1) DD233844A5 (da)
DE (1) DE3403922A1 (da)
DK (1) DK161890C (da)
ES (1) ES8607305A1 (da)
FI (1) FI80698C (da)
FR (1) FR2540500B1 (da)
GB (1) GB2134514B (da)
GR (1) GR81455B (da)
HU (1) HU190236B (da)
IE (1) IE56814B1 (da)
IL (1) IL70897A (da)
IT (1) IT1178855B (da)
LU (1) LU85199A1 (da)
NL (1) NL8400338A (da)
NO (1) NO161374C (da)
NZ (1) NZ206932A (da)
OA (1) OA07654A (da)
PH (1) PH20249A (da)
PT (1) PT78067B (da)
SE (1) SE461982B (da)
YU (1) YU44984B (da)
ZA (1) ZA84788B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246379A (ja) * 1987-03-31 1988-10-13 Kyowa Hakko Kogyo Co Ltd ７−ｎ，８−ｎ−エチレンマイトマイシン８−イミン類
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
JPS5686184A (en) * 1979-12-17 1981-07-13 Kyowa Hakko Kogyo Co Ltd Novel mitomycin c derivative
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes

Also Published As

Publication number Publication date
OA07654A (fr) 1985-05-23
IT1178855B (it) 1987-09-16
DK52484D0 (da) 1984-02-06
GR81455B (da) 1984-12-11
PT78067A (en) 1984-03-01
YU44984B (en) 1991-06-30
NO161374B (no) 1989-05-02
ATA37684A (de) 1987-09-15
SE8400628D0 (sv) 1984-02-07
LU85199A1 (fr) 1984-05-30
PH20249A (en) 1986-11-10
IE56814B1 (en) 1991-12-18
ES8607305A1 (es) 1986-05-16
IT8467113A0 (it) 1984-02-07
NO840433L (no) 1984-08-08
CA1252789A (en) 1989-04-18
FR2540500B1 (fr) 1987-07-17
FI840502A0 (fi) 1984-02-07
NL8400338A (nl) 1984-09-03
SE8400628L (sv) 1984-08-08
NZ206932A (en) 1987-08-31
AT385509B (de) 1988-04-11
FI80698B (fi) 1990-03-30
SE461982B (sv) 1990-04-23
CH658658A5 (de) 1986-11-28
IL70897A (en) 1989-01-31
DE3403922A1 (de) 1984-08-09
IL70897A0 (en) 1984-05-31
DK161890C (da) 1992-02-03
DK161890B (da) 1991-08-26
KR840007726A (ko) 1984-12-10
FI80698C (fi) 1990-07-10
AU571193B2 (en) 1988-04-14
IE840272L (en) 1984-08-07
YU21784A (en) 1986-10-31
HU190236B (en) 1986-08-28
JPS59152384A (ja) 1984-08-31
GB2134514A (en) 1984-08-15
BE898856A (fr) 1984-05-30
PT78067B (en) 1986-03-20
DD233844A5 (de) 1986-03-12
FI840502A (fi) 1984-08-08
AU2407384A (en) 1984-08-16
NO161374C (no) 1989-08-09
ES529478A0 (es) 1986-05-16
ZA84788B (en) 1984-09-26
FR2540500A1 (fr) 1984-08-10
GB8402233D0 (en) 1984-02-29
GB2134514B (en) 1987-04-01
DK52484A (da) 1984-08-08

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A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee