KR900006575B1 - 사독(蛇毒) 성장정지 펩티드, 및 그 수득 및 정제방법 - Google Patents

사독(蛇毒) 성장정지 펩티드, 및 그 수득 및 정제방법 Download PDF

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Publication number
KR900006575B1
KR900006575B1 KR1019860009886A KR860009886A KR900006575B1 KR 900006575 B1 KR900006575 B1 KR 900006575B1 KR 1019860009886 A KR1019860009886 A KR 1019860009886A KR 860009886 A KR860009886 A KR 860009886A KR 900006575 B1 KR900006575 B1 KR 900006575B1
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KR
South Korea
Prior art keywords
amino acid
aliphatic
carbon atoms
polar
toxic peptide
Prior art date
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Expired
Application number
KR1019860009886A
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English (en)
Korean (ko)
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KR870005014A (ko
Inventor
마르크바르트 한스
제이. 토다로 조지
알. 트바르드찌크 다니엘
Original Assignee
온코겐, 어 리미티드 파트너쉽
브래들리 더블유. 시몬스
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Publication of KR870005014A publication Critical patent/KR870005014A/ko
Application granted granted Critical
Publication of KR900006575B1 publication Critical patent/KR900006575B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/856—Snakes; venom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019860009886A 1985-11-22 1986-11-22 사독(蛇毒) 성장정지 펩티드, 및 그 수득 및 정제방법 Expired KR900006575B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/801,019 US4731439A (en) 1985-11-22 1985-11-22 Snake venom growth arresting peptide
US801019 1985-11-22
US801.019 1985-11-22

Publications (2)

Publication Number Publication Date
KR870005014A KR870005014A (ko) 1987-06-04
KR900006575B1 true KR900006575B1 (ko) 1990-09-13

Family

ID=25179974

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860009886A Expired KR900006575B1 (ko) 1985-11-22 1986-11-22 사독(蛇毒) 성장정지 펩티드, 및 그 수득 및 정제방법

Country Status (20)

Country Link
US (1) US4731439A (https=)
KR (1) KR900006575B1 (https=)
CN (1) CN86108593A (https=)
AU (3) AU6556386A (https=)
BE (1) BE905790A (https=)
CH (1) CH670451A5 (https=)
DE (1) DE3639796A1 (https=)
DK (1) DK560986A (https=)
ES (1) ES2002915A6 (https=)
FI (1) FI864715A7 (https=)
FR (1) FR2590576A1 (https=)
GB (1) GB2185023B (https=)
GR (1) GR862788B (https=)
IT (1) IT1207580B (https=)
LU (1) LU86683A1 (https=)
NL (1) NL8602939A (https=)
PT (1) PT83790B (https=)
SE (1) SE8604991L (https=)
YU (1) YU199586A (https=)
ZA (1) ZA868849B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5939890A (en) * 1989-06-07 1991-01-07 Genentech Inc. Platelet aggregation inhibitors and related molecules
WO1991001740A1 (en) * 1989-08-05 1991-02-21 Varánusz Gm Process for producing pharmacosmetics
US5232911A (en) * 1990-01-03 1993-08-03 Ventech Research Inc. Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
NZ253611A (en) * 1992-07-27 1996-09-25 Pfizer Polypeptide found in the venom of the agelenopsis spider and its use as a calcium channel blocker
DE4433890C2 (de) * 1994-09-22 1999-02-18 Deutsches Krebsforsch Konjugat aus einem Wirkstoff und einem nicht als körperfremd angesehenen, nativen Protein
SG129211A1 (en) * 1997-11-06 2007-02-26 Univ Singapore Therapeutic molecules
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
BRPI0501037B8 (pt) * 2005-03-18 2021-07-27 Fund De Amparo A Pesquisa Do Estado De Sao Paulo uso de crotamina e composição
US20060234934A1 (en) * 2005-04-15 2006-10-19 Kilmon Joseph A Composition and Method for Selective Cytostasis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836308B2 (ja) * 1977-02-10 1983-08-08 大塚製薬株式会社 抗体の製造方法
US4220722A (en) * 1978-02-10 1980-09-02 Syva Company Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4500637A (en) * 1982-07-19 1985-02-19 The United States Of America As Represented By The Department Of Health And Human Services Prevention of graft versus host disease following bone marrow transplantation

Also Published As

Publication number Publication date
US4731439A (en) 1988-03-15
GB8627710D0 (en) 1986-12-17
DK560986D0 (da) 1986-11-21
GB2185023B (en) 1990-08-29
PT83790A (en) 1986-12-01
DK560986A (da) 1987-05-23
IT1207580B (it) 1989-05-25
FR2590576A1 (fr) 1987-05-29
FI864715A7 (fi) 1987-05-23
CN86108593A (zh) 1987-09-30
ES2002915A6 (es) 1988-10-01
KR870005014A (ko) 1987-06-04
DE3639796A1 (de) 1987-07-09
ZA868849B (en) 1987-07-29
PT83790B (pt) 1989-09-14
AU6667590A (en) 1991-03-28
NL8602939A (nl) 1987-06-16
GB2185023A (en) 1987-07-08
SE8604991L (sv) 1987-05-23
AU6560986A (en) 1987-05-28
FI864715A0 (fi) 1986-11-19
CH670451A5 (https=) 1989-06-15
GR862788B (en) 1987-03-26
AU6556386A (en) 1987-05-28
SE8604991D0 (sv) 1986-11-21
BE905790A (fr) 1987-05-19
IT8622425A0 (it) 1986-11-21
LU86683A1 (fr) 1987-06-26
YU199586A (en) 1988-06-30

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