KR900004395A - 단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 방법 - Google Patents

단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 방법 Download PDF

Info

Publication number
KR900004395A
KR900004395A KR1019890013246A KR890013246A KR900004395A KR 900004395 A KR900004395 A KR 900004395A KR 1019890013246 A KR1019890013246 A KR 1019890013246A KR 890013246 A KR890013246 A KR 890013246A KR 900004395 A KR900004395 A KR 900004395A
Authority
KR
South Korea
Prior art keywords
solution
protein
albumin
chamber
heating
Prior art date
Application number
KR1019890013246A
Other languages
English (en)
Other versions
KR0135754B1 (ko
Inventor
커어니 대빗
제이.밀즈 게리
제이.웨스트캠퍼 피터
Original Assignee
빈센트 에이.프랭크
몰레큘라 바이오시스템즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 빈센트 에이.프랭크, 몰레큘라 바이오시스템즈 인코포레이티드 filed Critical 빈센트 에이.프랭크
Publication of KR900004395A publication Critical patent/KR900004395A/ko
Application granted granted Critical
Publication of KR0135754B1 publication Critical patent/KR0135754B1/ko

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 알부민용액의 제조를 도시한 순서도.
제2도는 예열, 공기도입 및 연속 초음파파쇄를 포함하는 초음파파쇄동작의 도식적 순서도.
제3도는 제2도의 초음파 파쇄베셀 대신 사용될 수 있는 초음파파쇄기의 확대 단면도.

Claims (10)

  1. 단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 초음파파쇄방법에 있어서, (a) 열변성, 수용성의, 생물학적으로 이용가능한 단백질의 묽은 수용액을 준비하는 단계 ; (b) 다소의 단백질 불용화없이 단백질의 초기변성온도까지 상기 용액을 신속히 가열하는 단계, (c) 초음파파쇄실로의 도입을 위해 상기 가열전, 가열동안 또는 가열 후, 생물학적으로 이용가능한 기체를 상기 용액의 증가분내로 유동시키는 단계, (d) 단백질의 일부를 불용화하기 위해 단백질이 가열되는 동안 초음파파쇄가 상기 용액을 기포화하고 기체 미세기포들을 제조하도록, 챔버에서 용액과 접촉하여 초음파파쇄혼을 제공하는 작동 음파파쇄기를 둘러싸는 챔버를 통해 단백질용액의 기체함유 가열증가분을 연속적으로 통과시키는 단계 ; 및 (e) 상기 챔버를 통과하는 용액의 증가분에서 안정한 단백질 캡슐밀봉된 미세규형체들을 연속적으로 형성시키는 단계 ; 로 이루어지는 것을 특징으로 하는 단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 초음파파쇄 방법.
  2. 제1항에 있어서, 상기 단백질이 인체혈청알부민인 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 상기 캡슐밀봉된 미세구형체가 거의 10미크론이하의 직경들을 갖는 것을 특징으로 하는 방법.
  4. 제1항에 있어서, 상기 챔버가 상기 초음파파쇄혼에 대해 대향하여 긴밀히 거리를 두어 배치된 캐비티제공벽부를 가지며, 상기 용액의 기체함유 가열증가분이 상기 캐비티로 도입되는 것을 특징으로 하는 방법.
  5. 제1항에 있어서, 상기 단백질이 인체혈청알부민이고, 상기 단계(b)의 가열이 70°와 75℃사이의 온도인 것을 특징으로 하는 방법.
  6. 제2항에 있어서, 상기 용액이 상기 알부민의 0.5 내지 7.5중량%를 함유하는 것을 특징으로 하는 방법.
  7. 단백질 캡슐밀봉된 미세규형체를 연속적으로 제조하기 위한 초음파파쇄방법에 있어서, (a) 인체혈청알부민의 묽은 수용액을 준비하는 단계 ; (b) 다소의 알부민 불용화없이 알부민에 대한 초기 변성온도까지 상기 용액의 증가분을 신속히 가열하는 단계 ; (c) 상기 공기가 상기 용액내로 들어갈 수 있도록 하기 위해 상기 용액을 가열한 직후 살균공기를 상기 용액의 증가분내로 유동시키는 단계 ; (d) 알부민의 일부를 불용화시키기 위해 알부민이 가열되는 동안 초음파파쇄가 상기 용액을 기포화시키고 기체 미세기포를 제조하도록, 챔버에서 용액과 접촉하여, 작동 초음파 파쇄기를 둘러싸는 챔버를 통해 상기 알부민용액의 공기함유가열증가분을 연속적으로 통과시키는 단계 ; (e) 상기 챔버를 통과하는 용액의 증가분에서 안정한 단백질 캡슐밀봉된 미세구형체들을 연속적으로 형성하는 단계 ; 로 이루어지는 것을 특징으로 하는 단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 초음파파쇄 방법.
  8. 제7항에 있어서, 상기 스텝(c)의 가열이 70°내지 75℃사이의 온도인 것을 특징으로 하는 방법.
  9. 제7항 또는 제8항에 있어서, 상기 용액이 상기 알부민이 0.5 내지 7.5중량%를 함유한 것을 특징으로 하는 방법.
  10. 제7항 또는 제8항에 있어서, 상기 용액이 상기 알부민의 0.5 내지 3중량%를 함유한 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013246A 1988-09-14 1989-09-12 단백질 캡슐화 미세기포를 제조하기 위한 연속 초음파 분해 방법 KR0135754B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US244,844 1988-09-14
US07/244,844 US4957656A (en) 1988-09-14 1988-09-14 Continuous sonication method for preparing protein encapsulated microbubbles
US244844 1988-09-14

Publications (2)

Publication Number Publication Date
KR900004395A true KR900004395A (ko) 1990-04-12
KR0135754B1 KR0135754B1 (ko) 1998-04-22

Family

ID=22924352

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890013246A KR0135754B1 (ko) 1988-09-14 1989-09-12 단백질 캡슐화 미세기포를 제조하기 위한 연속 초음파 분해 방법

Country Status (15)

Country Link
US (1) US4957656A (ko)
EP (1) EP0359246B1 (ko)
JP (1) JPH0720545B2 (ko)
KR (1) KR0135754B1 (ko)
AT (1) ATE87217T1 (ko)
AU (1) AU617215B2 (ko)
CA (1) CA1337286C (ko)
DE (1) DE68905557T2 (ko)
DK (1) DK175484B1 (ko)
ES (1) ES2054964T3 (ko)
FI (1) FI95872C (ko)
GR (1) GR3007483T3 (ko)
IE (1) IE62602B1 (ko)
IL (1) IL91593A0 (ko)
NO (1) NO176871C (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102296972B1 (ko) * 2021-02-18 2021-09-02 내외코리아 주식회사 소화용 마이크로 캡슐 제조장치

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086620A (en) * 1991-02-14 1992-02-11 Wayne State University Method of microencapsulation of hyperbaric gas
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (ko) * 1990-04-02 1993-05-01 Sint Sa
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
EP0504340B1 (en) * 1990-10-05 1995-06-21 BRACCO International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5179955A (en) * 1991-02-22 1993-01-19 Molecular Biosystems, Inc. Method of abdominal ultrasound imaging
US5107842A (en) * 1991-02-22 1992-04-28 Molecular Biosystems, Inc. Method of ultrasound imaging of the gastrointestinal tract
GB9106686D0 (en) † 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
GB9111880D0 (en) * 1991-06-03 1991-07-24 Unilever Plc Forming minute gas cells in a liquid medium
NZ244147A (en) † 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
CZ286149B6 (cs) * 1991-09-17 2000-01-12 Sonus Pharmaceuticals, Inc. Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
JPH05262673A (ja) * 1992-03-19 1993-10-12 Nippon Paint Co Ltd 超音波診断用造影剤
US5302372A (en) * 1992-07-27 1994-04-12 National Science Council Method to opacify left ventricle in echocardiography
WO1994007417A1 (en) * 1992-10-06 1994-04-14 Molecular Biosystems, Inc. Method of ultrasonic imaging of body cavities
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
JPH08502979A (ja) * 1992-11-02 1996-04-02 ドレクセル ユニバーシティー 表面活性剤で安定化された微小気泡混合物、その製造方法およびその使用方法
CN1042190C (zh) * 1992-12-02 1999-02-24 尤尼利弗公司 一种冷冻甜点心及其制备方法
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
CA2154590C (en) * 1993-01-25 2001-06-12 Steven C. Quay Phase shift colloids as ultrasound contrast agents
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
ES2068151B1 (es) 1993-06-23 1995-11-16 Cabrera Garrido Juan Microespuma inyectable para esclerosis.
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
PL312387A1 (en) * 1993-07-02 1996-04-15 Molecular Biosystems Inc Proteinous microbeads of encapsulated non-dissolving gas and method of making them and their application as ultrasonic visualisation medium
CA2164813C (en) 1993-07-30 2009-11-24 Ernest G. Schutt Stabilized microbubble compositions for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5385147A (en) * 1993-09-22 1995-01-31 Molecular Biosystems, Inc. Method of ultrasonic imaging of the gastrointestinal tract and upper abdominal organs using an orally administered negative contrast medium
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
AU679295B2 (en) 1993-12-15 1997-06-26 Bracco Suisse S.A. Gas mixtures useful as ultrasound contrast media
JPH10503480A (ja) * 1994-05-03 1998-03-31 モレキュラー バイオシステムズ， インコーポレイテッド 心筋の灌流を超音波で定量するための組成物
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5585064A (en) 1994-07-20 1996-12-17 The Goodyear Tire & Rubber Company Ventless segmented tire mold and method therefore
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5820850A (en) * 1995-06-07 1998-10-13 Molecular Biosystems, Inc. Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
AU1354497A (en) * 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
NZ331460A (en) * 1996-03-05 1998-12-23 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
DE69736981D1 (de) 1996-05-01 2007-01-04 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US5976501A (en) * 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
EP1683517A1 (en) 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
ES2289188T3 (es) * 1996-09-11 2008-02-01 Bristol-Myers Squibb Medical Imaging, Inc. Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador.
US6083484A (en) * 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
GB9708246D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Improvements in or relating to ultrasound imaging
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
AU7702798A (en) * 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
EP1023050B1 (en) * 1997-06-27 2013-09-25 Abraxis BioScience, LLC Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
DK1139799T3 (da) * 1998-12-23 2003-10-20 Unilever Nv Hældbare vand- og olieholdige emulsioner, der indeholder gasbobler
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
US6258419B1 (en) 1999-09-02 2001-07-10 Micron Technology, Inc. Sonication of monolayer films
US6210611B1 (en) 1999-11-30 2001-04-03 Duke University Methods for producing gas microbubbles having lipid-containing shells formed thereon
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
AU2003263024A1 (en) * 2002-04-23 2003-11-10 Christopher Mcconville Process of forming and modifying particles and compositions produced thereby
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
DK1694292T4 (en) 2003-11-17 2017-03-06 Btg Int Ltd Therapeutic foam comprising a sclerosing solution and a low amount of gaseous nitrogen
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CA2585675A1 (en) * 2004-11-03 2006-12-28 Iris Molecular Diagnostics, Inc. Microbubbles for affinity separation
EP1842226B2 (en) 2004-11-03 2014-07-02 Iris International, Inc. Homogeneous analyte detection
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7799023B2 (en) * 2005-09-26 2010-09-21 Coherex Medical, Inc. Compliant electrode for patent foramen ovale closure device
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US8221405B2 (en) * 2006-02-06 2012-07-17 Coherex Medical, Inc. Patent foramen ovale closure device and methods for determining RF dose for patent foramen ovale closure
US8402974B2 (en) * 2006-05-30 2013-03-26 Coherex Medical, Inc. Methods, systems, and devices for sensing, measuring, and controlling closure of a patent foramen ovale
US7938826B2 (en) * 2006-05-30 2011-05-10 Coherex Medical, Inc. Methods, systems, and devices for closing a patent foramen ovale using mechanical structures
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
KR100965479B1 (ko) * 2007-10-29 2010-06-24 한국식품연구원 초음파를 이용한 근육 단백질의 수용화 방법
US8647696B2 (en) 2008-12-12 2014-02-11 The University Of Birmingham Low fat food containing gas bubbles
US8167280B2 (en) 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
WO2011029094A2 (en) 2009-09-04 2011-03-10 The University Of North Carolina At Chapel Hill Systems, methods, and computer readable media for high- frequency contrast imaging and image-guided therapeutics
JP5427080B2 (ja) * 2010-03-23 2014-02-26 富士フイルム株式会社 微粒子製造方法及び微粒子製造装置
WO2012048335A2 (en) 2010-10-08 2012-04-12 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same
AU2013283409B2 (en) * 2012-06-26 2017-06-08 Ge Healthcare As Preparation of composition comprising gas microbubbles
WO2014055832A1 (en) 2012-10-04 2014-04-10 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
TWI616210B (zh) * 2016-01-07 2018-03-01 國立臺灣科技大學 經修飾微氣泡及其製備方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
EP0052575B1 (en) * 1980-11-17 1986-01-08 Schering Aktiengesellschaft Composition generating microbubbles
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102296972B1 (ko) * 2021-02-18 2021-09-02 내외코리아 주식회사 소화용 마이크로 캡슐 제조장치

Also Published As

Publication number Publication date
IE62602B1 (en) 1995-02-22
DK451189A (da) 1990-03-15
JPH0720545B2 (ja) 1995-03-08
ATE87217T1 (de) 1993-04-15
FI894335A0 (fi) 1989-09-13
JPH02115037A (ja) 1990-04-27
DE68905557D1 (de) 1993-04-29
NO176871C (no) 1995-06-14
CA1337286C (en) 1995-10-10
US4957656A (en) 1990-09-18
IE892837L (en) 1990-03-14
AU4131289A (en) 1990-03-22
DE68905557T2 (de) 1993-07-01
AU617215B2 (en) 1991-11-21
GR3007483T3 (ko) 1993-07-30
IL91593A0 (en) 1990-04-29
NO893671D0 (no) 1989-09-13
NO176871B (no) 1995-03-06
DK451189D0 (da) 1989-09-13
FI95872B (fi) 1995-12-29
EP0359246A3 (en) 1991-08-28
ES2054964T3 (es) 1994-08-16
FI894335A (fi) 1990-03-15
DK175484B1 (da) 2004-11-08
KR0135754B1 (ko) 1998-04-22
EP0359246B1 (en) 1993-03-24
EP0359246A2 (en) 1990-03-21
NO893671L (no) 1990-03-15
FI95872C (fi) 1996-04-10

Similar Documents

Publication Publication Date Title
KR900004395A (ko) 단백질 캡슐밀봉된 미세구형체들을 연속적으로 제조하기 위한 방법
KR960703624A (ko) 단백질 캡슐화 불용성 가스 마이크로스피어 및 그것의 제조 및 초음파 영상화제로서의 이용(protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents)
JP3094182B2 (ja) ケラチンｓ−スルフォ塩を壁構成原料として用いるマイクロカプセル及びその製造方法
Peacocke et al. Some biophysical aspects of ultrasound
JPS61288850A (ja) 人工的に製造された材料、構造部材および組織部材の無接触加工、特に破壊
Glass et al. Shock sphere—An apparatus for generating spherical flows

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20040707

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee