KR900000363A - 1-카바(데티아)세팔로스포린용 중간생성물 - Google Patents

1-카바(데티아)세팔로스포린용 중간생성물 Download PDF

Info

Publication number
KR900000363A
KR900000363A KR1019890008487A KR890008487A KR900000363A KR 900000363 A KR900000363 A KR 900000363A KR 1019890008487 A KR1019890008487 A KR 1019890008487A KR 890008487 A KR890008487 A KR 890008487A KR 900000363 A KR900000363 A KR 900000363A
Authority
KR
South Korea
Prior art keywords
phosphorus
chloride
imino
halide
detia
Prior art date
Application number
KR1019890008487A
Other languages
English (en)
Other versions
KR0138264B1 (ko
Inventor
클라라 보두로우 크리스티나
Original Assignee
메리 앤 터커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메리 앤 터커, 일라이 릴리 앤드 캄파니 filed Critical 메리 앤 터커
Publication of KR900000363A publication Critical patent/KR900000363A/ko
Application granted granted Critical
Publication of KR0138264B1 publication Critical patent/KR0138264B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

1-카바(데티아)세팔로스포린용 중간생성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 거의 순수한 형태의 하기 구조식의 화합물
  2. 제1항에 있어서, 하기 구조식의 화합물을 아미노 클로라이드-생성제와 반응시킨 후 아미노 에테르-생성 알콜과 반응시킴을 포함하는, 제1항의 화합물의 제조방법.
    상식 식에서, R은 벤질 또는 페녹시메틸이다.
  3. 제2항에 있어서, 이미노 클로라이드-생성제가 염화 인 인방법.
  4. 제3항에 있어서, 할로겐화 인 이 5염화 인, 3염화 인 또는 옥시염화 인 인방법.
  5. 제2항에 있어서, 이미노 할라이드 생성제가 트리페닐포스피트-염소 부가물인 방법.
  6. 제5항에 있어서, 이미노 할라이드 생성 단계가 약-30℃의 온도에서 실시되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890008487A 1988-06-22 1989-06-20 1-카바(데티아)세팔로스포린용 중간생성물 KR0138264B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20959688A 1988-06-22 1988-06-22
US7/209596 1988-06-22
US07/209596 1988-06-22

Publications (2)

Publication Number Publication Date
KR900000363A true KR900000363A (ko) 1990-01-30
KR0138264B1 KR0138264B1 (ko) 1998-05-15

Family

ID=22779423

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890008487A KR0138264B1 (ko) 1988-06-22 1989-06-20 1-카바(데티아)세팔로스포린용 중간생성물

Country Status (10)

Country Link
EP (1) EP0348124B1 (ko)
JP (1) JP2809711B2 (ko)
KR (1) KR0138264B1 (ko)
AT (1) ATE104977T1 (ko)
CA (1) CA1334971C (ko)
DE (1) DE68914888T2 (ko)
ES (1) ES2063129T3 (ko)
HU (1) HU207864B (ko)
IE (1) IE63268B1 (ko)
IL (1) IL90660A0 (ko)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208515A (en) * 1973-02-23 1980-06-17 Eli Lilly And Company 3-Halo cephalosporins
IE49377B1 (en) * 1979-02-01 1985-10-02 Lilly Co Eli Process for preparation of beta-lactam compounds
IL76367A0 (en) * 1984-09-17 1986-01-31 Lilly Co Eli Improved process for cephalsporin intermediates
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Also Published As

Publication number Publication date
CA1334971C (en) 1995-03-28
IE892017L (en) 1989-12-22
EP0348124B1 (en) 1994-04-27
ES2063129T3 (es) 1995-01-01
JP2809711B2 (ja) 1998-10-15
HUT50341A (en) 1990-01-29
ATE104977T1 (de) 1994-05-15
IL90660A0 (en) 1990-01-18
HU207864B (en) 1993-06-28
JPH0245484A (ja) 1990-02-15
IE63268B1 (en) 1995-04-05
KR0138264B1 (ko) 1998-05-15
DE68914888D1 (de) 1994-06-01
EP0348124A2 (en) 1989-12-27
DE68914888T2 (de) 1994-09-15
EP0348124A3 (en) 1990-05-09

Similar Documents

Publication Publication Date Title
NO931793D0 (no) Polyazamakrocykliske forbindelser for metallionkompleksdannelse
ATE208374T1 (de) Beta-laktam und cepham verbindungen und ihre herstellung
ES8802023A1 (es) Procedimiento para la obtencion de amidas de acidos benzoheterociclilalcanoicos
ES557111A0 (es) Procedimiento para la preparacion de acilazetidinonas opticamente activas
ES467601A1 (es) Procedimiento para la preparacion de derivados de cefem.
ES8700669A1 (es) Procedimiento de preparar derivados penam y sus sales
ATE21509T1 (de) Beta-lactam-essigsaeure-derivate, verfahren zu deren herstellung und deren verwendung als zwischenverbindungen fuer 1-azabicyclo(3.2.0)hept- 2-en-antibiotika.
SE7713901L (sv) Tiooximcefalosporin- och penicillin-derivat
DE3687200T2 (de) Cephalosporinderivate.
KR900000363A (ko) 1-카바(데티아)세팔로스포린용 중간생성물
DE3363312D1 (en) Process for preparing (3s)-3-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)-acetyl)amino)-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives
DK95280A (da) Brom-substituerede deacetoxycephalosporiner og fremgangsmaade til fremstilling heraf
ATE109157T1 (de) Fluor enthaltende renin-inhibitoren.
DE3585154D1 (de) Verfahren zur herstellung von cephalosporinestern.
MA19841A1 (fr) Procede de preparation de nouveaux derives de cephalosporines utilisables comme antibiotiques .
KR900006329A (ko) 카바세팔로스포린의 아제티디논 중간체 화합물 및 제조방법
ES8203379A1 (es) Un procedimiento para la preparacion de carbapenemas

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20110425

Year of fee payment: 15

EXPY Expiration of term