DE68914888D1 - Zwischenprodukt für 1-Carba(dethia)cephalosporin. - Google Patents

Zwischenprodukt für 1-Carba(dethia)cephalosporin.

Info

Publication number
DE68914888D1
DE68914888D1 DE68914888T DE68914888T DE68914888D1 DE 68914888 D1 DE68914888 D1 DE 68914888D1 DE 68914888 T DE68914888 T DE 68914888T DE 68914888 T DE68914888 T DE 68914888T DE 68914888 D1 DE68914888 D1 DE 68914888D1
Authority
DE
Germany
Prior art keywords
dethia
carba
cephalosporin
cephem
nitrobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68914888T
Other languages
English (en)
Other versions
DE68914888T2 (de
Inventor
Chistina Clara Bodurow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE68914888D1 publication Critical patent/DE68914888D1/de
Application granted granted Critical
Publication of DE68914888T2 publication Critical patent/DE68914888T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE68914888T 1988-06-22 1989-06-19 Zwischenprodukt für 1-Carba(dethia)cephalosporin. Expired - Fee Related DE68914888T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20959688A 1988-06-22 1988-06-22

Publications (2)

Publication Number Publication Date
DE68914888D1 true DE68914888D1 (de) 1994-06-01
DE68914888T2 DE68914888T2 (de) 1994-09-15

Family

ID=22779423

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914888T Expired - Fee Related DE68914888T2 (de) 1988-06-22 1989-06-19 Zwischenprodukt für 1-Carba(dethia)cephalosporin.

Country Status (10)

Country Link
EP (1) EP0348124B1 (de)
JP (1) JP2809711B2 (de)
KR (1) KR0138264B1 (de)
AT (1) ATE104977T1 (de)
CA (1) CA1334971C (de)
DE (1) DE68914888T2 (de)
ES (1) ES2063129T3 (de)
HU (1) HU207864B (de)
IE (1) IE63268B1 (de)
IL (1) IL90660A0 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208515A (en) * 1973-02-23 1980-06-17 Eli Lilly And Company 3-Halo cephalosporins
IE49377B1 (en) * 1979-02-01 1985-10-02 Lilly Co Eli Process for preparation of beta-lactam compounds
EP0175544A3 (de) * 1984-09-17 1987-06-03 Eli Lilly And Company Verfahren zur Herstellung von Cephalosporinzwischenverbindungen
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Also Published As

Publication number Publication date
HU207864B (en) 1993-06-28
EP0348124B1 (de) 1994-04-27
ES2063129T3 (es) 1995-01-01
KR0138264B1 (ko) 1998-05-15
IE892017L (en) 1989-12-22
IL90660A0 (en) 1990-01-18
ATE104977T1 (de) 1994-05-15
IE63268B1 (en) 1995-04-05
JP2809711B2 (ja) 1998-10-15
CA1334971C (en) 1995-03-28
DE68914888T2 (de) 1994-09-15
EP0348124A3 (en) 1990-05-09
KR900000363A (ko) 1990-01-30
HUT50341A (en) 1990-01-29
EP0348124A2 (de) 1989-12-27
JPH0245484A (ja) 1990-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee