IL90660A0 - Intermiediate for 1-carba(dethia)cephalosporin - Google Patents

Intermiediate for 1-carba(dethia)cephalosporin

Info

Publication number
IL90660A0
IL90660A0 IL90660A IL9066089A IL90660A0 IL 90660 A0 IL90660 A0 IL 90660A0 IL 90660 A IL90660 A IL 90660A IL 9066089 A IL9066089 A IL 9066089A IL 90660 A0 IL90660 A0 IL 90660A0
Authority
IL
Israel
Prior art keywords
dethia
carba
intermiediate
cephalosporin
cephem
Prior art date
Application number
IL90660A
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL90660A0 publication Critical patent/IL90660A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

p-Nitrobenzyl 7 beta -amino-3-hydroxy-1-carba(dethia)-3-cephem-4-carboxylate hydrochloride is provided as a crystalline solid. The salt is obtained by the N-deacylation of a p-nitrobenzyl 7-acylamino-3-hydroxy-1-carba(dethia)-3-cephem-4-carboxylate and is useful as an intermediate for 1-carbacephalosporin antibiotics.
IL90660A 1988-06-22 1989-06-19 Intermiediate for 1-carba(dethia)cephalosporin IL90660A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20959688A 1988-06-22 1988-06-22

Publications (1)

Publication Number Publication Date
IL90660A0 true IL90660A0 (en) 1990-01-18

Family

ID=22779423

Family Applications (1)

Application Number Title Priority Date Filing Date
IL90660A IL90660A0 (en) 1988-06-22 1989-06-19 Intermiediate for 1-carba(dethia)cephalosporin

Country Status (10)

Country Link
EP (1) EP0348124B1 (en)
JP (1) JP2809711B2 (en)
KR (1) KR0138264B1 (en)
AT (1) ATE104977T1 (en)
CA (1) CA1334971C (en)
DE (1) DE68914888T2 (en)
ES (1) ES2063129T3 (en)
HU (1) HU207864B (en)
IE (1) IE63268B1 (en)
IL (1) IL90660A0 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208515A (en) * 1973-02-23 1980-06-17 Eli Lilly And Company 3-Halo cephalosporins
IE49377B1 (en) * 1979-02-01 1985-10-02 Lilly Co Eli Process for preparation of beta-lactam compounds
EP0175544A3 (en) * 1984-09-17 1987-06-03 Eli Lilly And Company An improved process for cephalosporin intermediates
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Also Published As

Publication number Publication date
HU207864B (en) 1993-06-28
ATE104977T1 (en) 1994-05-15
KR0138264B1 (en) 1998-05-15
DE68914888D1 (en) 1994-06-01
ES2063129T3 (en) 1995-01-01
EP0348124A3 (en) 1990-05-09
DE68914888T2 (en) 1994-09-15
IE892017L (en) 1989-12-22
KR900000363A (en) 1990-01-30
EP0348124B1 (en) 1994-04-27
EP0348124A2 (en) 1989-12-27
HUT50341A (en) 1990-01-29
JPH0245484A (en) 1990-02-15
CA1334971C (en) 1995-03-28
IE63268B1 (en) 1995-04-05
JP2809711B2 (en) 1998-10-15

Similar Documents

Publication Publication Date Title
ES2001338A6 (en) 3-propenyl cephalosporin solvates
HK15497A (en) Crystalline beta-lactam hydrate
AU4732489A (en) Cephalosporin compounds
PH24993A (en) Novel cephalosporin derivatives
EP0180372A3 (en) Crystalline cephalosporin antibiotics
EP0348124A3 (en) Intermediate for 1-carba(dethia)cephalosporin
ATE202780T1 (en) 3-(SUBSTITUTED)-1-CARBA(DETHIA)-3- CEPHEM COMPOUNDS AND CEPHALOSPORINS AND A METHOD FOR THE PRODUCTION THEREOF
CA2002597A1 (en) Solvates of b-lactam antibiotic
DE3479731D1 (en) Substituted phenylglycine derivatives of beta-lactam antibiotics
PT80715A (en) Process for preparing cephalosporin antibiotics
IE841505L (en) Cephalosporin derivatives
HUT49616A (en) Process for producing crystalline beta-lactam solvates
FR2551757B1 (en) NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORIN TYPE ANTIBIOTICS
AU569001B1 (en) 7-(2-(2-aminothiazol-4-yl)-2(substituted hydoxyimino)acetamido)-3-cephem derivatives
HUT48890A (en) Process for producing cephalosporin derivative
EP0272061A3 (en) Crystalline cephalosporin antibiotic salts and solvates
IE862910L (en) Crystalline cephalosporin monohydrate
IL90497A0 (en) Azetidinone intermediates for 1-carba(dethia)cephalosporins
AU4138689A (en) Process for 1-carba(dethia)cephalosporins
ZA845162B (en) Substituted phenylglycine derivatives of beta-lactam antibiotics
IL72133A0 (en) Crystalline salts of an antibacterial cephalosporin derivative
IE871408L (en) Cephalosporin compounds
JPS6434991A (en) Carbonylation of beta-lactam antibiotic
GB8706874D0 (en) Cephalosporin derivatives
IE893226L (en) Crystalline dihydrochloride of a cephalosporin derivative

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees