KR890007731A - 생물학적으로 매우 유용한 형태의 철을 함유한 단백질 유도체, 그의 제조 및 이 화합물을 함유하는 제약 조성물 - Google Patents
생물학적으로 매우 유용한 형태의 철을 함유한 단백질 유도체, 그의 제조 및 이 화합물을 함유하는 제약 조성물 Download PDFInfo
- Publication number
- KR890007731A KR890007731A KR1019880014733A KR880014733A KR890007731A KR 890007731 A KR890007731 A KR 890007731A KR 1019880014733 A KR1019880014733 A KR 1019880014733A KR 880014733 A KR880014733 A KR 880014733A KR 890007731 A KR890007731 A KR 890007731A
- Authority
- KR
- South Korea
- Prior art keywords
- acylated
- lysozyme
- complex
- biologically
- compounds
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052742 iron Inorganic materials 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000016943 Muramidase Human genes 0.000 claims 4
- 108010014251 Muramidase Proteins 0.000 claims 4
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 4
- 229960000274 lysozyme Drugs 0.000 claims 4
- 235000010335 lysozyme Nutrition 0.000 claims 4
- 239000004325 lysozyme Substances 0.000 claims 4
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims 2
- VANNPISTIUFMLH-UHFFFAOYSA-N glutaric anhydride Chemical compound O=C1CCCC(=O)O1 VANNPISTIUFMLH-UHFFFAOYSA-N 0.000 claims 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid group Chemical group C(CCCC(=O)O)(=O)O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- MUTGBJKUEZFXGO-UHFFFAOYSA-N hexahydrophthalic anhydride Chemical compound C1CCCC2C(=O)OC(=O)C21 MUTGBJKUEZFXGO-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 무수 글루타르산 또는 1,2-시클로헥산디카르복실산 무수물로 아실화한 리소자임의 제일철 또는 제이철 복합체.
- 제1항에 있어서, 리소자임을 무수 글루타르산으로 아실화한 복합체.
- 제2항에 있어서, 리소자임이 글루타르산 잔기 11-12%를 함유한 복합체.
- pH 7.5-8사이 및 25℃내지 35℃에서, 리소자임을 과량의 무수무로 아실화하고, 아실화된 단백질을 희석시킨 알칼리중에 후속 용해시키고, 제일철염 또는 제이철염을 첨가하여 상기 용액에서 최종 침전물을 얻음으로 되는, 제1항-제3항에 의한 복합체의 제조방법.
- 유효 성분으로서 제약상 허용되는 담체와 혼합시킨 제1항-제3항의 복합체를 함유한, 철 결핍성 빈혈 치료용약제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22631/87A IT1223122B (it) | 1987-11-13 | 1987-11-13 | Derivati proteici del ferro altamente biodisponibile e tollerabili, loro preparazione e composizioni farmaceutiche che li contengono |
| IT22631A/87 | 1987-11-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR890007731A true KR890007731A (ko) | 1989-07-05 |
| KR970008109B1 KR970008109B1 (ko) | 1997-05-21 |
Family
ID=11198641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880014733A KR970008109B1 (ko) | 1987-11-13 | 1988-11-10 | 생물학적으로 매우 유용한 형태의 철을 함유한 단백질 유도체, 그의 제조방법 및 이 화합물을 함유하는 제약 조성물 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4939092A (ko) |
| EP (1) | EP0316709B1 (ko) |
| JP (1) | JPH01165377A (ko) |
| KR (1) | KR970008109B1 (ko) |
| AT (1) | ATE74515T1 (ko) |
| DE (1) | DE3869914D1 (ko) |
| ES (1) | ES2032209T3 (ko) |
| GR (1) | GR3004570T3 (ko) |
| IT (1) | IT1223122B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69115518T2 (de) * | 1990-01-09 | 1996-08-29 | Wako Pure Chem Ind Ltd | Verfahren zur Abtrennung und Messung von Spurbestandteilen |
| IT1251702B (it) * | 1991-10-16 | 1995-05-19 | Mediolanum Farmaceutici Srl | Complessi del ferro con la conalbumina e i suoi derivati |
| JP3106265B2 (ja) * | 1992-05-26 | 2000-11-06 | 株式会社コーセー | 修飾リゾチーム |
| JP5155502B2 (ja) | 2000-06-20 | 2013-03-06 | 雪印メグミルク株式会社 | 鉄含有タンパク質組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1150213B (it) * | 1982-03-02 | 1986-12-10 | Italfarmaco Spa | Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche |
| IT1207996B (it) * | 1986-03-18 | 1989-06-01 | Magis Farmaceutici | Composti contenenti ferro biodisponibile, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
-
1987
- 1987-11-13 IT IT22631/87A patent/IT1223122B/it active
-
1988
- 1988-10-27 US US07/263,542 patent/US4939092A/en not_active Expired - Fee Related
- 1988-11-08 ES ES198888118547T patent/ES2032209T3/es not_active Expired - Lifetime
- 1988-11-08 DE DE8888118547T patent/DE3869914D1/de not_active Expired - Fee Related
- 1988-11-08 EP EP88118547A patent/EP0316709B1/en not_active Expired - Lifetime
- 1988-11-08 AT AT88118547T patent/ATE74515T1/de not_active IP Right Cessation
- 1988-11-10 JP JP63284812A patent/JPH01165377A/ja active Pending
- 1988-11-10 KR KR1019880014733A patent/KR970008109B1/ko active IP Right Grant
-
1992
- 1992-05-12 GR GR920400918T patent/GR3004570T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1223122B (it) | 1990-09-12 |
| EP0316709B1 (en) | 1992-04-08 |
| DE3869914D1 (de) | 1992-05-14 |
| US4939092A (en) | 1990-07-03 |
| EP0316709A3 (en) | 1990-04-25 |
| KR970008109B1 (ko) | 1997-05-21 |
| JPH01165377A (ja) | 1989-06-29 |
| IT8722631A0 (it) | 1987-11-13 |
| ES2032209T3 (es) | 1993-01-16 |
| ATE74515T1 (de) | 1992-04-15 |
| EP0316709A2 (en) | 1989-05-24 |
| GR3004570T3 (ko) | 1993-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| NORF | Unpaid initial registration fee |