GB1346014A - Derivatives of alpha-ketoglutaric acid and their preparation - Google Patents

Derivatives of alpha-ketoglutaric acid and their preparation

Info

Publication number
GB1346014A
GB1346014A GB4712172A GB1346014DA GB1346014A GB 1346014 A GB1346014 A GB 1346014A GB 4712172 A GB4712172 A GB 4712172A GB 1346014D A GB1346014D A GB 1346014DA GB 1346014 A GB1346014 A GB 1346014A
Authority
GB
United Kingdom
Prior art keywords
alpha
derivatives
ketoglutaric acid
preparation
pyridoxamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4712172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Publication of GB1346014A publication Critical patent/GB1346014A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups

Abstract

1346014 α-Ketoglutaric acid derivatives LABORATORIOS MADE SA 12 Oct 1972 47121/72 Heading C2C The invention comprises pyridoxal alphaketoglutarate and pyridoxamine alpha-ketoglutarates of the formulµ They may be prepared by dissolving alphaketoglutaric acid and pyridoxal or pyridoxamine separately and mixing the solutions. If desired the salt may be used as such in pharmaceutical compositions or neutralized with an organic or inorganic base and used in the form of a double salt.
GB4712172A 1972-10-09 1972-10-12 Derivatives of alpha-ketoglutaric acid and their preparation Expired GB1346014A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH30674A CH561183A5 (en) 1972-10-09 1972-10-09
GB4712172 1972-10-12
BE790118 1972-10-13

Publications (1)

Publication Number Publication Date
GB1346014A true GB1346014A (en) 1974-02-06

Family

ID=27159418

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4712172A Expired GB1346014A (en) 1972-10-09 1972-10-12 Derivatives of alpha-ketoglutaric acid and their preparation

Country Status (3)

Country Link
BE (1) BE790118A (en)
CH (1) CH561183A5 (en)
GB (1) GB1346014A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
BR0008857A (en) 1999-03-08 2001-12-18 Medicure Inc Pyridoxal analogues for vitaminab-6 disorders
AU5840200A (en) 1999-07-13 2001-01-30 Medicure Inc. Treatment of diabetes and related pathologies
EP1210117A2 (en) 1999-08-24 2002-06-05 Medicure International Inc. Compositons for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
CA2401655C (en) 2000-02-29 2010-06-22 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003528146A (en) 2000-03-28 2003-09-24 メディキュア インターナショナル インコーポレイテッド Treatment of cerebrovascular disease
EP1299358B1 (en) 2000-07-07 2007-06-13 Medicure International Inc. Pyridoxine and pyridoxal analogues as cardiovascular therapeutics
US6897228B2 (en) 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
CA2585165A1 (en) 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs

Also Published As

Publication number Publication date
BE790118A (en) 1973-02-01
CH561183A5 (en) 1975-04-30

Similar Documents

Publication Publication Date Title
HK19481A (en) 3,4-dihydrocarbostyril derivatives,their preparation,and pharmaceutical compositions thereof
GB1346014A (en) Derivatives of alpha-ketoglutaric acid and their preparation
ES412387A1 (en) Formulation for oral administration of penicillins having improved taste properties
GB1399230A (en) Pyrazolodiazepine compounds and methods for their production
AU471079B2 (en) 5, 9, 13-prostatrienoic acid derivatives and process for their preparation
ES415226A1 (en) Method of enhancing vincamine compositions
IL39885A0 (en) Substituted xanthone carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
GB1394397A (en) Chlorphenesin derivatives and method of making same
GB1327560A (en) Effervescent pharmaceutical preparations
GB1311015A (en) Pharmaceutical compositions and a process for the manufacture thereof
CA710830A (en) Disodium and calcium salt of the calcium complex of 2-aminocyclohexyl 2'-aminoethyl ether-n,n,n',n'-tetraacetic acid
AU5590073A (en) 6-methylprednisolone derivatives, process for the preparation thereof and pharmaceutical compositions containing same
GB1224676A (en) Novel benzylthioethylamines, processes for their preparation, and compositions incorporating them
IL40623A (en) 14,15-dihydro-eburnamine-14-carboxylic acid derivatives and salts thereof,their preparation and pharmaceutical compositions containing them
GB1299289A (en) Piperidine derivatives
ES8105284A1 (en) Indoline derivatives, their production and pharmaceutical composition containing them
IL39888A (en) Heterocyclic-substituted xanthone carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
AU470779B2 (en) Novel 2-substituted 6,7-benzomorphan derivatives and salts thereof
GB1266430A (en)
GB1148758A (en) Substituted ªÐ-aminobenzamides, their preparation and use
GB1256735A (en)
GB1317099A (en) 3-sulphamyl-4-chlorobenzoic acid derivatives
GB1289065A (en)
GB1338750A (en) Therapeutic composition
GB1230298A (en)

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee