KR890005127A - 항균제로서 유용한 4-옥소-3-퀴놀린카르복실산과 그의 제조방법 - Google Patents
항균제로서 유용한 4-옥소-3-퀴놀린카르복실산과 그의 제조방법 Download PDFInfo
- Publication number
- KR890005127A KR890005127A KR1019880011580A KR880011580A KR890005127A KR 890005127 A KR890005127 A KR 890005127A KR 1019880011580 A KR1019880011580 A KR 1019880011580A KR 880011580 A KR880011580 A KR 880011580A KR 890005127 A KR890005127 A KR 890005127A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- hydrogen
- fluoro
- oxo
- pyridinyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 일반 구조식을 갖는 화합물; 또는 이들의 제약학적으로 허용 가능한 산-부가염; 또는 R이 수소인 화합물의 알칼리 금속 또는 아민염:상기식에서 R은 수소 또는 저급알킬이며: R´는 수소, 플루오로 또는 -SR″′이며(이때 R″´는 벤질, 페닐 또는 저급알킬임); R″는 1-3개의 탄소원자를 갖는 알킬이며; X는O또는 S이다.
- 제1항에 있어서, R이 수소이고 R′는 수소 또는 플루오로인 화합물.
- 제2항에 따른 (S)-10-(2,6-디메틸-4-피리디닐)-8,9-디플루오로-3-메틸-7-옥소-2,3-디히드로-7H-피리도[1,2,3-데]-[1,4]벤족사진-6-카르복실산.
- 제2항에 따른 (S)-10-(2,6-디메틸-4-피리디닐)-9-플루오로-3-메틸-7-옥소-2,3-디히드로-7H-피리도[1,2,3-데]-[1,4]벤족사진-6-카르복실산.
- 제2항에 따른 (S)-10-(2,6-디메틸-4-피리디닐)-9-플루오로-3-에틸-7-옥소-2,3-디히드로-7H-피리도[1,2,3-데][1,4]벤족사진-6-카르복실산.
- 제1항에 따른 (S)-10-(2,6-디메틸-4-피리디닐)-9-플루오로-3-메틸-7-옥소-8-(벤질티오)-2,3-디히드로-7H-피리도-[1,2,3-데][1,4]벤족사진-6-카르복실산.
- 제2항에 따른 (S)-10-(2,6-디메틸-4-피리디닐)-9-플루오로-3-메틸-7-옥소-2,3-디히드로-7H-피리도[1,2,3-데][1,4]벤조티아진-6-카르복실산.
- a) 하기 일반 구조식(Ⅱ)의 화합물:(상기식에서 R은 저급-알킬이며 R´는 수소 또는 플루오로임)을 하기 일반구조식의 화합물:상기식에서 Alk는 1-6개의 탄소원자를 갖는 알킬임)과 반응시켜 X가 O인 일반 구조식 Ⅰ의 상응하는 화합물을 제조하고; 또는 b) 하기 일반구조식의 화합물:(상기식에서 R은 저급-알킬이며 R´는 수소 또는 플루오로임)을 황화 수소와 반응시켜 X가 S인 일반구조식 Ⅰ의 상응하는 화합물을 제조하며 ; 원한다면, 얻어진 일반구조식 I의 상기 화합물을 가수분해시켜 R이 수소인 상응하는 화합물을 얻고, 원한다며, R´가 플루오로인 얻어진 일반구조식 Ⅰ의 화합물을 R″′SH 황화물과 반응시켜 R´가 SR″′인 일반구조식 I의 화합물을 제조하고, 원한다면 후자의 화합물을 라네이 니켈과 가열하여 -SH"'기를 수소로 치환시키고, 원한다며, 얻어진 유리염기를 전환시켜 이들의 산-부가염을 얻고, 원한다며, R이 수소인 얻어진 화합물을 염기와 반응시켜 이들의 알칼리 금속 또는 아민염을 얻는 것을 포함하는 제1항 또는 제2항에 따르는 화합물의 제조방법.
- 한가지 이상의 제약학적으로 허용가능한 부형제, 희석제, 담체 또는 용매와 함께 항균적으로 효과적인 양의 제1항에 따르는 화합물을 포함하는 박테리아 방제용 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US094,611 | 1979-11-15 | ||
US9461187A | 1987-09-09 | 1987-09-09 | |
US220717 | 1988-07-18 | ||
US07/220,717 US4839355A (en) | 1987-09-09 | 1988-07-18 | Tricyclic-pyridinylquinoline compounds, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890005127A true KR890005127A (ko) | 1989-05-11 |
Family
ID=26789072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880011580A KR890005127A (ko) | 1987-09-09 | 1988-09-07 | 항균제로서 유용한 4-옥소-3-퀴놀린카르복실산과 그의 제조방법 |
Country Status (13)
Country | Link |
---|---|
US (1) | US4839355A (ko) |
EP (1) | EP0306860A3 (ko) |
JP (1) | JPH01139583A (ko) |
KR (1) | KR890005127A (ko) |
AU (1) | AU599829B2 (ko) |
DK (1) | DK494088A (ko) |
FI (1) | FI884107A (ko) |
IL (1) | IL87553A (ko) |
MY (1) | MY103393A (ko) |
NO (1) | NO883898L (ko) |
NZ (1) | NZ225927A (ko) |
PH (1) | PH25930A (ko) |
PT (1) | PT88432B (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196429B (it) * | 1986-07-01 | 1988-11-16 | Mediolanum Farmaceutici Srl | Processo per la preparazione di pirido benzotiazine ad attivita' antibatterica e loro sali con acidi solfonici |
US5188833A (en) * | 1987-12-28 | 1993-02-23 | Kyorin Seiyaku Kabushiki Kaisha | Freeze-dried pharmaceutical preparations for parenteral use |
DE3902079A1 (de) * | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
AU640481B2 (en) | 1990-04-18 | 1993-08-26 | Norwich Eaton Pharmaceuticals, Inc. | Penicillan or cephalosporin derivatives of quinolonyl |
US5308843A (en) * | 1990-09-11 | 1994-05-03 | Sterling Drug Inc. | Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids |
US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
JP4621356B2 (ja) * | 1999-02-05 | 2011-01-26 | 富山化学工業株式会社 | 三環キノロンカルボン酸誘導体またはその塩 |
JPWO2007037330A1 (ja) * | 2005-09-28 | 2009-04-09 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
SG10201505811QA (en) * | 2011-08-31 | 2015-09-29 | Otsuka Pharma Co Ltd | Quinolone compound |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3753993A (en) * | 1971-05-17 | 1973-08-21 | Sterling Drug Inc | 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives |
US3840544A (en) * | 1972-06-19 | 1974-10-08 | Sterling Drug Inc | Alkyl 4-alkoxy-7-(pyridyl)-3-quinoline-carboxylates,their preparation and conversion to corresponding 4-oxo compounds |
JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
US4638067A (en) * | 1982-09-09 | 1987-01-20 | Warner-Lambert Co. | Antibacterial agents |
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
US4529725A (en) * | 1984-04-26 | 1985-07-16 | Abbott Laboratories | 1-Pyridine substituted quino-benzothiazine |
US4540694A (en) * | 1984-04-26 | 1985-09-10 | Abbott Laboratories | 1-Pyridine substituted quino-benoxazines and antibacterial use |
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
EP0179239A3 (en) * | 1984-09-17 | 1986-08-13 | Sterling Drug Inc. | 7-(pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid having antibacterial activity and preparation thereof |
US4698350A (en) * | 1984-09-17 | 1987-10-06 | Sterling Drug Inc. | 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof |
US4636506A (en) * | 1984-12-06 | 1987-01-13 | Pfizer, Inc. | 7-heterocyclic-1,4-dihydroquinolones |
DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
FR2634483B2 (fr) * | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments |
-
1988
- 1988-07-18 US US07/220,717 patent/US4839355A/en not_active Expired - Fee Related
- 1988-08-24 IL IL87553A patent/IL87553A/xx unknown
- 1988-08-24 PH PH37450A patent/PH25930A/en unknown
- 1988-08-24 NZ NZ225927A patent/NZ225927A/xx unknown
- 1988-08-31 AU AU21718/88A patent/AU599829B2/en not_active Ceased
- 1988-09-01 NO NO88883898A patent/NO883898L/no unknown
- 1988-09-02 EP EP88114389A patent/EP0306860A3/en not_active Withdrawn
- 1988-09-06 DK DK494088A patent/DK494088A/da not_active Application Discontinuation
- 1988-09-06 FI FI884107A patent/FI884107A/fi not_active Application Discontinuation
- 1988-09-06 PT PT88432A patent/PT88432B/pt not_active IP Right Cessation
- 1988-09-07 KR KR1019880011580A patent/KR890005127A/ko not_active Application Discontinuation
- 1988-09-07 JP JP63224385A patent/JPH01139583A/ja active Pending
- 1988-09-09 MY MYPI88001006A patent/MY103393A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI884107A (fi) | 1989-03-10 |
FI884107A0 (fi) | 1988-09-06 |
MY103393A (en) | 1993-06-30 |
AU599829B2 (en) | 1990-07-26 |
EP0306860A3 (en) | 1990-07-18 |
DK494088A (da) | 1989-03-10 |
IL87553A0 (en) | 1989-01-31 |
PH25930A (en) | 1991-12-19 |
PT88432A (pt) | 1989-07-31 |
JPH01139583A (ja) | 1989-06-01 |
NZ225927A (en) | 1990-06-26 |
EP0306860A2 (en) | 1989-03-15 |
PT88432B (pt) | 1992-10-30 |
US4839355A (en) | 1989-06-13 |
NO883898D0 (no) | 1988-09-01 |
DK494088D0 (da) | 1988-09-06 |
IL87553A (en) | 1992-05-25 |
NO883898L (no) | 1989-03-10 |
AU2171888A (en) | 1989-03-09 |
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