KR890003801A - 인간 reg 단백질 - Google Patents

인간 reg 단백질 Download PDF

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Publication number
KR890003801A
KR890003801A KR1019880010051A KR880010051A KR890003801A KR 890003801 A KR890003801 A KR 890003801A KR 1019880010051 A KR1019880010051 A KR 1019880010051A KR 880010051 A KR880010051 A KR 880010051A KR 890003801 A KR890003801 A KR 890003801A
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KR
South Korea
Prior art keywords
amino acid
acid sequence
gln
ala
protein
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KR1019880010051A
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English (en)
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KR940000199B1 (ko
Inventor
히로시 오까모또
다까꼬 이또오
히로시 데라오까
히로시게 쓰즈끼
노부오 요시다
Original Assignee
요시또시 가즈오
시오노 기세이야꾸 가부시끼가이샤
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Application filed by 요시또시 가즈오, 시오노 기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR890003801A publication Critical patent/KR890003801A/ko
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Publication of KR940000199B1 publication Critical patent/KR940000199B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/474—Pancreatic thread protein; Reg protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

인간 REG 단백질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 인간 reg cDNA의 염기서열 및 그로부터 추정되는 아미노산 서열을 나타낸 것이다. 제 2 도는 쥐 reg cDNA의 염기서열 및 그로부터 추정되는 아미노산 서열을 나타낸 것이다. 제 3 도는 hu reg로 약칭된 인간 reg를 위한 형질발현 플라스미드의 형성을 나타낸 것이다.

Claims (4)

  1. 제 1 도에 나타낸 아니노산 서열에서 Ala(1번째), Gly(21번째), Gln(22번째), Glu(23번째), Ala(24번째), Gln(25번째), Gln(30번째), Ala(31번째) 또는 He(33번째)로 부터 Asn(165번째) 까지의아미노산 서열 또는 이 아미노산 서열의 N-말단에 Met를 더 갖는 아미노산 서열을 함유하는 단백질.
  2. 제 1 항에 있어서, 아미노산 서열이 제 1 도에 나타낸 아미노산 서열에서 Gln(22번째), Glu(23번째) 또는 He(33번째)로 부터 Asn(165번째)까지인 단백질.
  3. 제 1 도에서 나타낸 아미노산 서열에서 Ala(1번째), Gly(21번째), Gln(22번째), Glu(23번째), Ala(24번째), Gln(25번째), Gln(30번째), Ala(31번째) 또는 He(33번째)로 부터 Asn(165번째) 까지의아미노산 서열 또는 이 아미노산 서열의 N-말단에 Met를 더 갖는 아미노산 서열을 함유하는 단백질을 코오딩하는 유전자를 갖는 형 질발현 백터를 도입한 숙주를 배양하고 배양액으로 부터 그 단백질을 회수함을 특징으로 하는 상기 단백질의 제조방법.
  4. 제 3항에 있어서, 숙주가 사카로미세스 세레비시아에 (Saccharomyces cerevisie)인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880010051A 1987-08-10 1988-08-06 인간 reg 단백질 KR940000199B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP200514/1987 1987-08-10
JP20051487 1987-08-10
JP62-200514 1987-08-10

Publications (2)

Publication Number Publication Date
KR890003801A true KR890003801A (ko) 1989-04-18
KR940000199B1 KR940000199B1 (ko) 1994-01-12

Family

ID=16425579

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880010051A KR940000199B1 (ko) 1987-08-10 1988-08-06 인간 reg 단백질

Country Status (8)

Country Link
EP (1) EP0303233A3 (ko)
JP (1) JPH01137994A (ko)
KR (1) KR940000199B1 (ko)
AU (1) AU604147B2 (ko)
CA (1) CA1339758C (ko)
DK (1) DK174067B1 (ko)
HU (1) HUT47640A (ko)
NZ (1) NZ225738A (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02200700A (ja) * 1989-01-30 1990-08-08 Shionogi & Co Ltd 新規ｒｅｇ蛋白質
AU643971B2 (en) * 1989-10-18 1993-12-02 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Production and use of human NM23 protein and antibodies therefor
JP3570557B2 (ja) * 1992-12-01 2004-09-29 塩野義製薬株式会社 ｒｅｇタンパク質を有効成分とする薬剤
WO1996011950A1 (en) * 1994-10-13 1996-04-25 Amgen Inc. Method of treating diabetes mellitus using kgf
US5866546A (en) * 1997-04-18 1999-02-02 Hadasit Medical Research Services And Development Company Ltd. Treatment for diabetes
ES2270817T3 (es) 1999-04-07 2007-04-16 Hiroshi Okamoto Metodo para evaluar enfermedades autoinmunes, metodo para detectar autoanticuerpos de la proteina anti-reg y diagnosticos para enfermedades autoinmunes.
US8211430B2 (en) 2005-03-04 2012-07-03 Curedm Group Holdings, Llc Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions
CA2609667C (en) 2005-05-25 2011-02-22 Curedm, Inc. Human proislet peptide, derivatives and analogs thereof, and methods of using same
US8785400B2 (en) 2006-11-22 2014-07-22 Curedm Group Holdings, Llc Methods and compositions relating to islet cell neogenesis
SI2193142T1 (sl) 2007-08-30 2015-05-29 Curedm Group Holdings, Llc Sestavek in postopek za uporabo proislet peptidov in analogov le-teh

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2560213B2 (ja) * 1986-08-22 1996-12-04 東北大学長 インスリノ−マで特異的に発現している遺伝子のｄｎａ

Also Published As

Publication number Publication date
EP0303233A2 (en) 1989-02-15
NZ225738A (en) 1991-07-26
AU2066188A (en) 1989-02-16
CA1339758C (en) 1998-03-17
DK444288D0 (da) 1988-08-09
DK444288A (da) 1989-02-11
EP0303233A3 (en) 1989-06-14
HUT47640A (en) 1989-03-28
JPH01137994A (ja) 1989-05-30
AU604147B2 (en) 1990-12-06
DK174067B1 (da) 2002-05-21
KR940000199B1 (ko) 1994-01-12

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