KR880007067A - 마이크로 캡슐 및 그 제조방법 - Google Patents

마이크로 캡슐 및 그 제조방법 Download PDF

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Publication number
KR880007067A
KR880007067A KR870013860A KR870013860A KR880007067A KR 880007067 A KR880007067 A KR 880007067A KR 870013860 A KR870013860 A KR 870013860A KR 870013860 A KR870013860 A KR 870013860A KR 880007067 A KR880007067 A KR 880007067A
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South Korea
Prior art keywords
wax
solvent
core material
particles
microcapsule
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KR870013860A
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English (en)
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KR950002149B1 (ko
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시쥬오 아이시마
요시또 다까하시
마사끼 코세무라
마사아끼 오까와라
Original Assignee
마사아끼 오까와라
오까와라 가고끼 가부시끼 가이샤
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Publication of KR950002149B1 publication Critical patent/KR950002149B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S426/00—Food or edible material: processes, compositions, and products
    • Y10S426/805—Pet food for dog, cat, bird, or fish
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medicinal Preparation (AREA)
  • Feed For Specific Animals (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)

Abstract

내용 없음.

Description

마이크로 캡슐 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 방법에 의한 대표적인 1실시예를 나타낸 플로우차아트,
제2도는 본 발명의 실시예 1에서 얻는 마이크로 캡슐의 고조를 나타낸 주사 타입의 전자현미경 사진,
제3도는 본 발명의 실시예 1에서 얻은 것으로 용융－냉각－고화처리 후 마이크로 캡슐의 구조를 나타낸 주사 타입의 전자현미경 사진.

Claims (8)

  1. 코어물질 입자의 표면에 두께 0.1∼10μm의 층으로 왁스 또는 왁스와 단백질의 혼합물을 코팅시키는 5μm∼5mm의 입자를 구성시킴을 특징으로한 마이크로 캡슐.
  2. 제1항에 있어서, 상기 마이크로 캡슐은 서로 결합하여 멀티－코어타입의 마이크로 캡슐을 형성함을 특징으로 한 상기 마이크로 캡슐.
  3. 왁스 또는 왁스와 단백질의 혼합물을 유기산과 물로 구성된 혼합 용매중에 용해시켜, 얻어진 용액으로 온도 45℃ 또는 그 이하에서 코어물질 입자의 표면을 습윤(wetting)시키며, 상기 코어물질 입자의 표면에 왁스 또는 왁스와 단백질의 혼합물을 선택적으로 침착하여 입자표면을 코팅하도록 한 다음 입자를 포함하는 슬러리를 용매제거 처리시킴을 특징으로 하는 마이크로 캡슐의 제조방법.
  4. 제3항에 있어서, 상기 유기용매는 물과 혼화할 수 있는 극성 용매임을 특징으로 한 상기 방법.
  5. 제4항에 있어서, 상기 극성 용매는 메타놀, 에타놀, 프로파놀, 아세톤 또는 메틸에틸 케톤임을 특징으로 한 상기방법.
  6. 제3항에 있어서, 상기 혼합 용매 중의 상기 유기용매의 농도는 65∼95vol%임을 특징으로 한 상기방법.
  7. 제3항에 있어서, 상기 코어물질 입자에는 수용성 물질을 포함시킴을 특징으로 한 상기방법.
  8. 제3항에 있어서, 상기 왁스는 유기용매에 용해할 수 있음을 특징으로 한 상기방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870013860A 1986-12-15 1987-12-04 마이크로 캡슐 및 그 제조방법 KR950002149B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP86-298366 1986-12-15
JP61-298366 1986-12-15
JP61298366A JPS63151353A (ja) 1986-12-15 1986-12-15 ワツクスコ−テイングマイクロカプセルの製造方法

Publications (2)

Publication Number Publication Date
KR880007067A true KR880007067A (ko) 1988-08-26
KR950002149B1 KR950002149B1 (ko) 1995-03-14

Family

ID=17858758

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870013860A KR950002149B1 (ko) 1986-12-15 1987-12-04 마이크로 캡슐 및 그 제조방법

Country Status (6)

Country Link
US (1) US4943449A (ko)
EP (1) EP0275358B1 (ko)
JP (1) JPS63151353A (ko)
KR (1) KR950002149B1 (ko)
CN (1) CN1015963B (ko)
DE (1) DE3777141D1 (ko)

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FR2660554B1 (fr) * 1990-04-05 1992-07-03 Oreal Composition cosmetique ou dermo-pharmaceutique aqueuse contenant en suspension des spherouides hydrates d'une substance lipidique hydrophile.
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JP2553258B2 (ja) * 1991-05-20 1996-11-13 三菱化学株式会社 ワックス被覆製剤の製造方法
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US5160742A (en) * 1991-12-31 1992-11-03 Abbott Laboratories System for delivering an active substance for sustained release
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US5571166A (en) * 1992-03-19 1996-11-05 Medtronic, Inc. Method of making an intraluminal stent
US5510077A (en) * 1992-03-19 1996-04-23 Dinh; Thomas Q. Method of making an intraluminal stent
US5599352A (en) * 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
RU2121830C1 (ru) * 1992-09-18 1998-11-20 Яманоути Фармасьютикал Ко., ЛТД Гидрогелевый препарат с длительным высвобождением лекарства
JP4792149B2 (ja) * 1997-09-09 2011-10-12 リオトロピック セラピュティックス アイエヌシー． 被覆粒子とその製造法及び使用法
DE10007322A1 (de) * 2000-02-17 2001-08-23 Cognis Deutschland Gmbh Perlglanzmittel
AU9418501A (en) * 2000-10-04 2002-04-15 Kyowa Hakko Kogyo Kk Method of coating fine particle with lipid film
EP1243326A1 (de) * 2001-03-22 2002-09-25 Cognis Iberia, S.L. Nanokapseln (II)
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US9050393B2 (en) * 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
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Also Published As

Publication number Publication date
US4943449A (en) 1990-07-24
JPH0533095B2 (ko) 1993-05-18
DE3777141D1 (de) 1992-04-09
JPS63151353A (ja) 1988-06-23
EP0275358B1 (en) 1992-03-04
CN1015963B (zh) 1992-03-25
CN87108128A (zh) 1988-07-13
KR950002149B1 (ko) 1995-03-14
EP0275358A1 (en) 1988-07-27

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