KR880007067A - 마이크로 캡슐 및 그 제조방법 - Google Patents
마이크로 캡슐 및 그 제조방법 Download PDFInfo
- Publication number
- KR880007067A KR880007067A KR870013860A KR870013860A KR880007067A KR 880007067 A KR880007067 A KR 880007067A KR 870013860 A KR870013860 A KR 870013860A KR 870013860 A KR870013860 A KR 870013860A KR 880007067 A KR880007067 A KR 880007067A
- Authority
- KR
- South Korea
- Prior art keywords
- wax
- solvent
- core material
- particles
- microcapsule
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/805—Pet food for dog, cat, bird, or fish
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- General Preparation And Processing Of Foods (AREA)
- Formation And Processing Of Food Products (AREA)
- Medicinal Preparation (AREA)
- Feed For Specific Animals (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fodder In General (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 방법에 의한 대표적인 1실시예를 나타낸 플로우차아트,
제2도는 본 발명의 실시예 1에서 얻는 마이크로 캡슐의 고조를 나타낸 주사 타입의 전자현미경 사진,
제3도는 본 발명의 실시예 1에서 얻은 것으로 용융-냉각-고화처리 후 마이크로 캡슐의 구조를 나타낸 주사 타입의 전자현미경 사진.
Claims (8)
- 코어물질 입자의 표면에 두께 0.1∼10μm의 층으로 왁스 또는 왁스와 단백질의 혼합물을 코팅시키는 5μm∼5mm의 입자를 구성시킴을 특징으로한 마이크로 캡슐.
- 제1항에 있어서, 상기 마이크로 캡슐은 서로 결합하여 멀티-코어타입의 마이크로 캡슐을 형성함을 특징으로 한 상기 마이크로 캡슐.
- 왁스 또는 왁스와 단백질의 혼합물을 유기산과 물로 구성된 혼합 용매중에 용해시켜, 얻어진 용액으로 온도 45℃ 또는 그 이하에서 코어물질 입자의 표면을 습윤(wetting)시키며, 상기 코어물질 입자의 표면에 왁스 또는 왁스와 단백질의 혼합물을 선택적으로 침착하여 입자표면을 코팅하도록 한 다음 입자를 포함하는 슬러리를 용매제거 처리시킴을 특징으로 하는 마이크로 캡슐의 제조방법.
- 제3항에 있어서, 상기 유기용매는 물과 혼화할 수 있는 극성 용매임을 특징으로 한 상기 방법.
- 제4항에 있어서, 상기 극성 용매는 메타놀, 에타놀, 프로파놀, 아세톤 또는 메틸에틸 케톤임을 특징으로 한 상기방법.
- 제3항에 있어서, 상기 혼합 용매 중의 상기 유기용매의 농도는 65∼95vol%임을 특징으로 한 상기방법.
- 제3항에 있어서, 상기 코어물질 입자에는 수용성 물질을 포함시킴을 특징으로 한 상기방법.
- 제3항에 있어서, 상기 왁스는 유기용매에 용해할 수 있음을 특징으로 한 상기방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP86-298366 | 1986-12-15 | ||
JP61-298366 | 1986-12-15 | ||
JP61298366A JPS63151353A (ja) | 1986-12-15 | 1986-12-15 | ワツクスコ−テイングマイクロカプセルの製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880007067A true KR880007067A (ko) | 1988-08-26 |
KR950002149B1 KR950002149B1 (ko) | 1995-03-14 |
Family
ID=17858758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870013860A KR950002149B1 (ko) | 1986-12-15 | 1987-12-04 | 마이크로 캡슐 및 그 제조방법 |
Country Status (6)
Country | Link |
---|---|
US (1) | US4943449A (ko) |
EP (1) | EP0275358B1 (ko) |
JP (1) | JPS63151353A (ko) |
KR (1) | KR950002149B1 (ko) |
CN (1) | CN1015963B (ko) |
DE (1) | DE3777141D1 (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2166919T3 (es) * | 1989-08-30 | 2002-05-01 | Kynoch Agrochemicals Proprieta | Preparacion de un dispositivo dosificador. |
FR2660554B1 (fr) * | 1990-04-05 | 1992-07-03 | Oreal | Composition cosmetique ou dermo-pharmaceutique aqueuse contenant en suspension des spherouides hydrates d'une substance lipidique hydrophile. |
US5102402A (en) | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
JP2553258B2 (ja) * | 1991-05-20 | 1996-11-13 | 三菱化学株式会社 | ワックス被覆製剤の製造方法 |
US5250236A (en) * | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
US5591224A (en) * | 1992-03-19 | 1997-01-07 | Medtronic, Inc. | Bioelastomeric stent |
US5571166A (en) * | 1992-03-19 | 1996-11-05 | Medtronic, Inc. | Method of making an intraluminal stent |
US5510077A (en) * | 1992-03-19 | 1996-04-23 | Dinh; Thomas Q. | Method of making an intraluminal stent |
US5599352A (en) * | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
RU2121830C1 (ru) * | 1992-09-18 | 1998-11-20 | Яманоути Фармасьютикал Ко., ЛТД | Гидрогелевый препарат с длительным высвобождением лекарства |
JP4792149B2 (ja) * | 1997-09-09 | 2011-10-12 | リオトロピック セラピュティックス アイエヌシー. | 被覆粒子とその製造法及び使用法 |
DE10007322A1 (de) * | 2000-02-17 | 2001-08-23 | Cognis Deutschland Gmbh | Perlglanzmittel |
AU9418501A (en) * | 2000-10-04 | 2002-04-15 | Kyowa Hakko Kogyo Kk | Method of coating fine particle with lipid film |
EP1243326A1 (de) * | 2001-03-22 | 2002-09-25 | Cognis Iberia, S.L. | Nanokapseln (II) |
ES2187380A1 (es) * | 2001-11-16 | 2003-06-01 | Sanchez Juan Balufo | Mejoras introducidas en productos destinados al consumo humano o animal. |
US20040043070A1 (en) * | 2002-05-14 | 2004-03-04 | Ayres James W. | Hot melt coating by direct blending and coated substrates |
US9050393B2 (en) * | 2005-02-08 | 2015-06-09 | Bruce N. Saffran | Medical devices and methods for modulation of physiology using device-based surface chemistry |
US7828840B2 (en) * | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
CN102125171A (zh) * | 2010-01-12 | 2011-07-20 | 杭州康德权饲料有限公司 | 一种微囊化包膜氧化锌的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3857933A (en) * | 1969-10-17 | 1974-12-31 | Hoechst Ag | Process for the manufacture of a drug dosage form permitting controlled release of active ingredient |
CA923384A (en) * | 1970-02-03 | 1973-03-27 | Abe Jinnosuke | Process for preparing a micro capsule |
JPS49107855A (ko) * | 1973-02-03 | 1974-10-14 | ||
GB1413186A (en) * | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
JPS5231981A (en) * | 1975-08-18 | 1977-03-10 | Takeda Chem Ind Ltd | Microcapsule preparation method |
JPS5619324A (en) * | 1979-07-24 | 1981-02-24 | Asahi Electronics | Wheel passage type anchoring clamp |
JPS56140915A (en) * | 1980-04-07 | 1981-11-04 | Yamanouchi Pharmaceut Co Ltd | Pharmaceutical preparation for solid drug |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
FR2526328A1 (fr) * | 1982-05-04 | 1983-11-10 | Centre Nat Rech Scient | Microcapsules a paroi obtenue par reticulation des proteines du lait, et leur procede de preparation |
JPS61174940A (ja) * | 1985-01-29 | 1986-08-06 | Oogawara Kakoki Kk | ワックス類コーテイング単核状マイクロカプセルおよびその製造方法 |
JPH078659B2 (ja) * | 1988-07-18 | 1995-02-01 | 株式会社クボタ | トラクタのエンジンボンネット取付構造 |
-
1986
- 1986-12-15 JP JP61298366A patent/JPS63151353A/ja active Granted
-
1987
- 1987-09-01 US US07/091,793 patent/US4943449A/en not_active Expired - Fee Related
- 1987-09-03 EP EP87112909A patent/EP0275358B1/en not_active Expired - Lifetime
- 1987-09-03 DE DE8787112909T patent/DE3777141D1/de not_active Expired - Fee Related
- 1987-12-04 KR KR1019870013860A patent/KR950002149B1/ko not_active IP Right Cessation
- 1987-12-15 CN CN87108128A patent/CN1015963B/zh not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4943449A (en) | 1990-07-24 |
JPH0533095B2 (ko) | 1993-05-18 |
DE3777141D1 (de) | 1992-04-09 |
JPS63151353A (ja) | 1988-06-23 |
EP0275358B1 (en) | 1992-03-04 |
CN1015963B (zh) | 1992-03-25 |
CN87108128A (zh) | 1988-07-13 |
KR950002149B1 (ko) | 1995-03-14 |
EP0275358A1 (en) | 1988-07-27 |
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