KR880006256A - 항비루스성 포스포노메톡시알킬렌푸린과 피리미딘 유도체 - Google Patents

항비루스성 포스포노메톡시알킬렌푸린과 피리미딘 유도체 Download PDF

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KR880006256A
KR880006256A KR1019870012967A KR870012967A KR880006256A KR 880006256 A KR880006256 A KR 880006256A KR 1019870012967 A KR1019870012967 A KR 1019870012967A KR 870012967 A KR870012967 A KR 870012967A KR 880006256 A KR880006256 A KR 880006256A
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compound
guanine
phosphonomethoxy
ethyl
hydrogen
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KR1019870012967A
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KR950009195B1 (ko
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알. 웨브 2세 로버트
제이. 브론슨 죠안느
씨. 마틴 존
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이삭 쟈코브스키
브리스톨 마이어즈 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
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  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

항비루스성 포스포노메톡시알킬렌푸린과 피리미딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (27)

  1. B가 아데닌, 크산틴, 하이포잔틴, 구아니, 8-브로모구아닌, 8-클로로구아닌, 8-아미노구아닌, 8-히드라지노구아닌, 8-히드록시구아닌, 8-메틸구아닌, 8-티오구아닌, 2-아미노푸란, 2,6-디아미노푸린, 시토신, 5-에틸시토신, 5-메틸시토신, 티민, 우라실, 5-브로모우라실, 5-에틸우라실, 5-요오드우라실, 5-프로필우라실, 5-비닐우라실 및 5-브로모비닐우라실로 이루어지는 그룹으로 부터 선택되는 푸린이나 피리미딘 염기이며; B가 아데닌이며 alk1이 메틸렌인 경우 alk2는 화학 결합이 될 수 없다는 것을 조건으로 하여 alk1,alk2,alk3는 화학 결합이나 C1-4알킬렌으로 부터 독립적으로 선택되며, B가 아데닌이고, Q가 수소인 경우 alk1은 단지 C4H8만이 될 수 있음을 조건으로 하여 Q는 수소 및 수산기이고; R1과 R2는 수소 및 C1-4알킬로부터 독립적으로 선택되고; R3및 R4는 수소, C1-6알킬, 페닐 및 페닐-C1-4-알킬렌으로 부터 독립적으로 선택되는 다음 일반식 I의 화합물 및 그에 상응하는 염, 양성이온, 및/또는 용매화합물.
  2. B가 푸린염기인 제1항의 화합물.
  3. 푸린염기가 구아닌 성분인 제2항의 화합물.
  4. B가 피리미딘 염기인 제1항의 화합물.
  5. R1,R2및 Q가 수소인 제2항의 화합물.
  6. R3와 R4가 수소인 제1항의 화합물.
  7. R3와 R4중 하나가 수소이고 다른 하나가 C1-6알킬인 제1항의 화합물.
  8. 9-(3-히드록시-2-포스포노메톡시프로필)구아닌인 제1항의 화합물.
  9. 9-(2-포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  10. 9-(3-포스포노메톡시)프로필)구아닌인 제1항의 화합물.
  11. 9-(4-포스포노메톡시)부틸)구아닌인 제1항의 화합물.
  12. 8-브로모-9-(2-포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  13. 1-(4-포스포노메톡시)부틸)티민인 제1항의 화합물.
  14. 9-(1-메틸-2-(포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  15. 9-(2-(포스포노메톡시)-1-프로필)구아닌인 제1항의 화합물.
  16. 9-(2-히드록시메틸-3-(포스포노메톡시)프로필)구아닌인 제1항의 화합물.
  17. 9-(2-히드록시메틸-3-(포스포노메톡시)프로필)아데닌인 제1항의 화합물.
  18. 8-메틸-9-(2-(포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  19. 9-(4-히드록시-3-(포스포노메톡시)부틸)구아닌인 제1항의 화합물.
  20. 9-(4-히드록시-3-(포스포노메톡시)부틸)아데닌인 제1항의 화합물.
  21. 9-(2-단일에틸포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  22. 9-(2-단일메틸포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  23. 9-(2-단일-n-프로필포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  24. 9-(2-단일-이소프로필포스포노메톡시)에틸)구아닌인 제1항의 화합물.
  25. 9-(2-(1-포스포노-1-에톡시)에틸)구아닌인 제1항의 화합물.
  26. 제1항 화합물의 효과적인 항비루스양과 제약학적으로 허용되는 담체가 혼합되어 이루어지는 항비루스용 제약학적 조성물.
  27. 항비루스 화합물이 9-(2-(포스포노메톡시)에틸)구아닌인 제26항의 제약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870012967A 1986-11-18 1987-11-18 항 비루스성 포스포노메톡시알킬렌 푸린 및 피리미딘 유도체 KR950009195B1 (ko)

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US93211286A 1986-11-18 1986-11-18
US932,112 1986-11-18
US11434087A 1987-11-04 1987-11-04
US932112 1987-11-04

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KR950009195B1 KR950009195B1 (ko) 1995-08-16

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EP (1) EP0269947B2 (ko)
JP (1) JP2593895B2 (ko)
KR (1) KR950009195B1 (ko)
AU (1) AU613592B2 (ko)
CA (1) CA1339780C (ko)
DE (1) DE3780581T3 (ko)
DK (1) DK170049B1 (ko)
EG (1) EG19346A (ko)
ES (1) ES2033774T5 (ko)
GR (2) GR3005256T3 (ko)
IL (1) IL84477A (ko)
NZ (1) NZ222553A (ko)

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EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
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ES2033774T3 (es) 1993-04-01
DE3780581T2 (de) 1992-12-17
AU613592B2 (en) 1991-08-08
JPS63170388A (ja) 1988-07-14
NZ222553A (en) 1991-07-26
DK604087A (da) 1988-05-19
IL84477A (en) 1995-12-08
CA1339780C (en) 1998-03-24
DE3780581D1 (de) 1992-08-27
EP0269947B1 (en) 1992-07-22
ES2033774T5 (es) 1997-03-16
EP0269947B2 (en) 1996-10-16
GR3005256T3 (en) 1993-05-24
KR950009195B1 (ko) 1995-08-16
EP0269947A1 (en) 1988-06-08
AU8125087A (en) 1988-05-19
EG19346A (en) 1995-01-31
DK170049B1 (da) 1995-05-08
GR3021389T3 (en) 1997-01-31
DK604087D0 (da) 1987-11-17
DE3780581T3 (de) 1997-06-05
JP2593895B2 (ja) 1997-03-26

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