KR880005947A - 전신 약품의 경피 투여용 침투 증강제 - Google Patents

전신 약품의 경피 투여용 침투 증강제 Download PDF

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KR880005947A
KR880005947A KR870012978A KR870012978A KR880005947A KR 880005947 A KR880005947 A KR 880005947A KR 870012978 A KR870012978 A KR 870012978A KR 870012978 A KR870012978 A KR 870012978A KR 880005947 A KR880005947 A KR 880005947A
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drug
hydrogen
oxodecyl
lower alkyl
effective
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KR870012978A
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미내스카니언 게볼크
반올덴 펙 제임스
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케네쓰 이.이킨스
넬슨 리써취 앤드 디벨럽먼트 캄파니
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Application filed by 케네쓰 이.이킨스, 넬슨 리써취 앤드 디벨럽먼트 캄파니 filed Critical 케네쓰 이.이킨스
Publication of KR880005947A publication Critical patent/KR880005947A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/44—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using insoluble pigments or auxiliary substances, e.g. binders
    • D06P1/64—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using insoluble pigments or auxiliary substances, e.g. binders using compositions containing low-molecular-weight organic compounds without sulfate or sulfonate groups
    • D06P1/642—Compounds containing nitrogen
    • D06P1/6426—Heterocyclic compounds

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
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  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

전신 약품의 경피 투여용 침투 증강제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식을 갖는 막 침투 증강제 및 그의 염 유효량을 국소 투여하는 점이 개선된, 전신에 유효한 약품을 경피 투여용 장치 또는 제제물로 인체 및 동물의 피부 또는 점막을 통하여 국소 투여하는 방법.
    상기 식 중, X는 황, 산소 또는 질소이고, a 및 b는 0 또는 1이고, c는 0, 1 또는 2이되, 단 X가 산소일 경우, a, b 및 c는 0이고, X가 질소일 경우, c는 0이고, a 또는 b 중에서 어느 하나만이 1이고, X가 황일 경우, a 및 b는 0이고, A는 0 내지 2개의 2중 결합을 갖는 분지쇄 또는 직쇄의 2가 지방족기이고, R'는 수소, 1 내지 4개의 탄소원자를 갖는 저급 알킬기, 페닐, 아세트아미도, 할로겐, 저급알킬 또는 할로겐 치환 피페리디닐, 카르브알콕시, 카르복스아미드 및 알카노일로 되는 군 중에서 선택되고, R은 수소 또는 1 내지 4개의 탄소원자를 갖는 저급알킬기,
    (여기에서, R"은 수소 또는 할로겐임)이다.
  2. 제1항에 있어서, R이 수소 또는 저급 알킬기이고, R'가 수소이고, X가 산소이고, A가 일반식 - (CH2-) -n(식 중, n은 0 내지 17임)으로 표시되는 2가 기인 방법.
  3. 제2항에 있어서, n이 4 내지 16인 방법.
  4. 제3항에 있어서, n이 10인 방법.
  5. 제1항에 있어서, 전신에 유효한 약품이 치료 약품인 방법.
  6. 제5항에 있어서, 투여가 동시에 일어나는 방법.
  7. 제1항에 있어서, 막 침투 증강제가 N- (1-옥소데실)모르폴린, N-(1-옥소데실)피페라진, 1,4-비스(1-옥소데실)피페라지늄 클로라이드 및 N-(1-옥소데실)티오모르폴린 중에서 선택되는 방법.
  8. 제1항에 있어서, 전신에 유효한 약품이 할로페리돌, 이소소르바이드 디니트레이트, 니트로글리세린,에스트라디올, 클로니딘, 프로프라놀롤, 인도메타신, 니페디핀, 니카르디핀, 디클로로페낙 및 메타프로테레놀로 되는 군 중에서 선택되는 방법.
  9. 제7항에 있어서, 전신에 유효한 약품이 할로페리돌, 이소소르바이드 디니트레이트, 니트로글리세린, 에스트라디올, 클로니딘, 프로프라놀롤, 인도메타신, 니페디핀, 니카르디핀, 디클로로페낙 및 메타프로테레놀로 되는 군 중에서 선택되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870012978A 1986-11-19 1987-11-18 전신 약품의 경피 투여용 침투 증강제 KR880005947A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US932709 1986-11-19
US06/932,709 US4917896A (en) 1986-08-15 1986-11-19 Penetration enhancers for transdermal delivery of systemic agents

Publications (1)

Publication Number Publication Date
KR880005947A true KR880005947A (ko) 1988-07-21

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US (1) US4917896A (ko)
EP (1) EP0268222B1 (ko)
JP (1) JP2514672B2 (ko)
KR (1) KR880005947A (ko)
AU (1) AU602368B2 (ko)
DE (1) DE3751761T2 (ko)

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AU602368B2 (en) 1990-10-11
JPS63139137A (ja) 1988-06-10
EP0268222A3 (en) 1988-09-14
DE3751761T2 (de) 1996-09-19
AU8132787A (en) 1988-05-26
US4917896A (en) 1990-04-17
JP2514672B2 (ja) 1996-07-10
EP0268222B1 (en) 1996-03-27
DE3751761D1 (de) 1996-05-02
EP0268222A2 (en) 1988-05-25

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