KR860008139A - 2,3- 디페닐- 치환된 γ- 니트릴- 에스테르의 폐환생성물을 제조하는 방법 - Google Patents
2,3- 디페닐- 치환된 γ- 니트릴- 에스테르의 폐환생성물을 제조하는 방법 Download PDFInfo
- Publication number
- KR860008139A KR860008139A KR1019860002571A KR860002571A KR860008139A KR 860008139 A KR860008139 A KR 860008139A KR 1019860002571 A KR1019860002571 A KR 1019860002571A KR 860002571 A KR860002571 A KR 860002571A KR 860008139 A KR860008139 A KR 860008139A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- nitrile
- diphenyl
- ester
- substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000007363 ring formation reaction Methods 0.000 title claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- -1 phenoxy, benzyloxy Chemical group 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 239000002699 waste material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 순수한 시스 유도체를 제조하는 경우에는 일반식(A)의 2,3-디페닐-치환된 γ-니트릴-에스테르의 순수한 에리트로 유도체를 30 내지 100℃에서 10 내지 80bar의 압력하에 수소화하거나 수수한 트란스 유도체를 제조하는 경우에는 일반식(A)의 2,3-디페닐-치환된 γ-니트릴-에스테르의 순수한 트레오유도체나 에리트로 유도체를 80 내지 180℃에서 80 내지 180bar의 압력하에 수소화시킴을 특징으로 하여 일반식(C)의 2,3-디페닐-치환된 γ-니트릴-에스테르의 폐한생성물을 제조하는 방법.상기 식에서, R은 수소, 약제학적으로 허용가능한 알칼리금속 또는 알칼리토금속, 또는 C1-C4알킬그룹이고; 일반식(A)에서, X 및 Y는 동일하거나 상이하며, 수소, 할로겐, C1-C4알킬, C1-C4알콕시, 페닐, 페닐-(C1-C4알킬) 또는 트리플루오로메틸그룹이고; 일반식(C)에서, X 및 Y는 동일하거나 상이하며 수소, 할로겐, 트리플루오로메틸, C1-C4알킬, 페닐, 페닐-(C1-C4알킬), C1-C4알콕시, 하이드록시, 아실옥시, 페녹시, 벤질옥시, C1-C4알킬설포닐 또는 디(C1-C4알킬)아미노 그룹이며; n은 X 및/또는 Y가 수소가 아닌 경우에 1 내지 3이다.
- 제1항에 있어서 출발물질인 2,3-디페닐-치환된 γ-니트릴-에스테르가 다음 구조식(Ⅰ) 내지 (Ⅷ)중의 하나인 방법.상기 식에서, R은 수소 약제학적으로 허용가능한 알칼리 금속 또는 알칼리 토금속, 또는 C1-C4알킬그룹니다.
- 제1항에 있어서, 폐환생성물이 다음 구조식(XI) 내지 (ⅩⅩⅥ)중의 하나인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8505123A FR2587339B1 (fr) | 1985-04-04 | 1985-04-04 | Nouveaux medicaments constitues par des derives-2,3 ou -3,4 diphenyles des esters g-nitriles ou leurs produits de cyclisation et procedes pour les preparer |
| FR8505123 | 1985-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860008139A true KR860008139A (ko) | 1986-11-12 |
Family
ID=9317941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860002571A KR860008139A (ko) | 1985-04-04 | 1986-04-04 | 2,3- 디페닐- 치환된 γ- 니트릴- 에스테르의 폐환생성물을 제조하는 방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4785007A (ko) |
| EP (1) | EP0203308A2 (ko) |
| JP (1) | JPS61229854A (ko) |
| KR (1) | KR860008139A (ko) |
| AU (1) | AU5561786A (ko) |
| DK (1) | DK151586A (ko) |
| ES (4) | ES8802219A1 (ko) |
| FR (1) | FR2587339B1 (ko) |
| GR (1) | GR860891B (ko) |
| PT (1) | PT82333B (ko) |
| ZA (1) | ZA862458B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI875101A (fi) * | 1986-12-03 | 1988-06-04 | Tanabe Seiyaku Co | Laktamderivat och preparat innehaollande dessa. |
| AU2006276292B2 (en) * | 2005-07-22 | 2010-09-16 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE765203C (de) * | 1939-08-02 | 1953-06-01 | Ig Farbenindustrie Ag | Verfahren zur Herstellung von Piperidonen und Piperidinen |
| US3468893A (en) * | 1966-03-14 | 1969-09-23 | Ciba Geigy Corp | 1-substituted-diphenyl-azacycloalkenes |
| US3956314A (en) * | 1970-07-24 | 1976-05-11 | U.C.B., Societe Anonyme | Derivatives of 2-pyrrolidinone |
| US3814771A (en) * | 1970-11-19 | 1974-06-04 | T Shen | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones |
| US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
| AU518986B2 (en) * | 1977-10-11 | 1981-10-29 | Takeda Chemical Industries Ltd. | Lactams |
-
1985
- 1985-04-04 FR FR8505123A patent/FR2587339B1/fr not_active Expired
-
1986
- 1986-03-27 EP EP86104231A patent/EP0203308A2/de not_active Withdrawn
- 1986-04-02 ES ES553642A patent/ES8802219A1/es not_active Expired
- 1986-04-02 US US06/847,255 patent/US4785007A/en not_active Expired - Fee Related
- 1986-04-03 DK DK151586A patent/DK151586A/da not_active IP Right Cessation
- 1986-04-03 AU AU55617/86A patent/AU5561786A/en not_active Abandoned
- 1986-04-03 JP JP61075679A patent/JPS61229854A/ja active Pending
- 1986-04-03 ZA ZA862458A patent/ZA862458B/xx unknown
- 1986-04-03 PT PT82333A patent/PT82333B/pt unknown
- 1986-04-03 GR GR860891A patent/GR860891B/el unknown
- 1986-04-04 KR KR1019860002571A patent/KR860008139A/ko not_active Application Discontinuation
-
1987
- 1987-07-16 ES ES557626A patent/ES8802491A1/es not_active Expired
- 1987-07-16 ES ES557625A patent/ES8802490A1/es not_active Expired
-
1988
- 1988-01-15 ES ES557801A patent/ES8802221A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61229854A (ja) | 1986-10-14 |
| ES557801A0 (es) | 1988-04-16 |
| US4785007A (en) | 1988-11-15 |
| FR2587339A1 (fr) | 1987-03-20 |
| ZA862458B (en) | 1986-11-26 |
| PT82333A (fr) | 1986-05-01 |
| ES8802219A1 (es) | 1988-04-16 |
| ES557625A0 (es) | 1988-07-01 |
| PT82333B (fr) | 1988-04-07 |
| ES557626A0 (es) | 1988-07-01 |
| DK151586A (da) | 1986-10-05 |
| ES553642A0 (es) | 1988-04-16 |
| GR860891B (en) | 1986-08-04 |
| ES8802491A1 (es) | 1988-07-01 |
| DK151586D0 (da) | 1986-04-03 |
| FR2587339B1 (fr) | 1988-08-05 |
| ES8802221A1 (es) | 1988-04-16 |
| ES8802490A1 (es) | 1988-07-01 |
| EP0203308A2 (de) | 1986-12-03 |
| AU5561786A (en) | 1986-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |